High-Risk Cytogenetics

Name:

Which of the following cytogenetic abnormalities were not considered in the analysis?

t(4;14)

t(14;20)

t(14;16)

del17p

What proportion of patients in the DVd group had high cytogenetic risk abnormalities?

57%

44%

29%

16%

14%

mPFS for DVd vs Vd at first relapse in patients with high-risk abnormalities was...?

12.6 vs 6.2 months

16.6 vs 6.6 months

20.1 vs 8.4 months

29.8 vs 7.5 months

Did the addition of daratumumab to bortezomib and dexamethasone impact the rate of AEs in any specific cytogenetic risk subgroup?

Yes, the rate of AEs was higher in the favorable risk subgroup

Yes, the rate of AEs was higher in the intermediate risk subgroup

No significant difference in AE rates among the subgroups

AE rates were not reported in the paper

What percentage of patients in the high-risk subgroup achieved a very good partial response (VGPR) or better with DVd treatment?

Less than 10%

Approximately 20%

Approximately 40%

Approximately 60%

Was the comparison of VGPR in the high-risk subgroup statistically significant?

Yes

p-value not reported

What was the relative risk reduction in disease progression or death for patients with high-risk cytogenetics with DVd at first relapse?

20%

40%

60%

80%

What was the time to response for patients with high-risk cytogenetics vs standard risk patients?

same time to response

faster time to response

delayed time to response

The discontinuation rate due to TEAEs for patient with standard risk receiving DVd was 8%. What was the rate for high-risk patients receiving DVd?

10%

11%

Fill in the blank: DVd more than ________ rates of complete response or better vs Vd alone in patients with high-risk cytogenetics

Halved

Double

Tripled

This was not reported

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