Second Chance - Sepsis

Along with suspected infection + addnl criteria, what qualifies for septic shock?
SBP < 90mmHg
MAP < 70mmHg
SBP decrease > 40 mmHg
 
A change in SOFA score of what number from baseline indicates organ dysfunction?
1
2
3
SOFA Score looks at what factors?
RR
PLT
Bili
MAP/Vasopressor
Glasgow-coma
SCr or UO
What empiric therapy should be started? (SELECT ALL THAT APPLY)
Vanco
Pip/tazo
Tobra
Levo
If only 1 IV line, what abx to start first and how soon from arrival should it be started?
Gram-negative coverage with 1 hour
Gram-positive within 1 hour
What is anticipated duration of tx? day 1 = day of appropriate abx given, incl empiric
7-10 days
10-14 days
What if bacteria (+), what is duration of tx?
14 days from first negative blood culture
 
What are the hemodynamic goals for initial resuscitation?
CVP 8-12 mmHg
MAP > 65 mmHg
UO > 0.5ml/kg/hr
What is an appropriate crystalloid fluid to give?
NaCl 30ml/kg at a rate of 1L/30min
Albumin
What percentage of NaCl stays in intravascular space?
25%
50%
History of multi-drug resistant gram negative infection/colonization within past 90 days or Prior IV broad spec for >72hrs within last 14 days.
Meropenam + Vanco + Amikacin if no beta-lactam allergy
Aztreonam + Vanco + Amikacin + Tigecyclin if beta-lactam allergy
What to add if possible intra-abd catastrophy?
Micafungin
What to do if no risk factors empirically?
Pip/tazo + Vanco + Tobramycin if no beta-lactam allergy
Aztreonam + Vanco + Tobra if beta-lactam allergy
Goal for MAP and SCVO2?
Map > 65 mmHg
SCVO2 70%
When should NE be given?
If fluids do not help
If NE does not work, what should be given next?
Vasopressin - supplements inadequate endogenous vasopressin
Epi
When should hydrocortisone 50mg IV q6hrs be used?
When NE + Epi + Vasopressin on board
When NE + Vasopressin on board
When Vasopressin + Epi on board
What if HR and MAP resolved but SCVO2 and CO are still low?
Add dobutamine (inotropic, potent beta1 agonist)
NEVER USE MILRINONE
What to do if patient develops a-fib from NE?
Phenylephrine (can worsen HF)
Titrate down NE
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