Question 59

You astutely suspect Primary CNS lymphoma in a 72 year old gentleman who presented with recurrent posterior uveitis. You do a vitreous biopsy to obtain some of the cellular infiltrate. The most likely cytologic description of the abnormal vitreous cells in a patient with Primary CNS lymphoma would be:

Plasma cells with atypical nucleoli

Tissue macrophages expressing CD45

Large lymphocytes with high nucleus to cytoplasm ratio

Mature T lymphocytes expressing CD8

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