Immunology

Patient for transplant rejection prophylaxis was given Calcineurin inhibitor, both of these drugs are associated with Nephrotoxicity, however one of them is associated with increased risk of diabetes and does NOT significantly increase risk of Gingival Hyperplasia or Hirsutism, what is molecular mechanism by which this drug suppresses immune system?

Blocks T Cell activation by Preventing IL2 transcription as it can bind with FKBP(FK508 Binding Protein) and inhibit Calcineurin 2.

Complexes with Cyclophilin and prevents IL2 transcription by preventing dephosphorylation of NFATP to NFAT by Calcineurin

Binds FKBP and inhibits mTOR , thus preventing Growth of T cells and Differentiation of B cells in response to IL2

Decreases Response to/effect of IL2 by blocking its receptor

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