Bio Psych_Quiz 1

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Bio Psych Quiz: Test Your Neuropharmacology Knowledge

Welcome to the Bio Psych Quiz, where you can evaluate your understanding of key concepts in neuropharmacology and receptor biology. This quiz contains 20 thought-provoking questions that challenge your knowledge on neurotransmitters, antipsychotic drugs, and mechanisms of action at various receptors.

Discover your strengths in pharmacological knowledge.
Learn about the mechanisms behind common psychotropic medications.
Enhance your understanding of dopamine and its role in psychiatric disorders.

20 Questions5 MinutesCreated by LearningBrain42

Which of the following is not a criterion for a receptor?

Which of the following definitions best describes a partial agonist at a receptor?

Substances which initiate less than the maximal response in at the receptor

The ease with which the substance combines with its receptor

The ability of a drug to initiate a response

Substances which initiate a maximal response at the receptor

The dose or concentration needed to elicit a standard response

The putative mechanism of action of the majority of antipsychotic drugs in current therapeutic use is blockade of post synaptic dopamine D2 receptors. As a consequence of this action which statement is true?

They are indicated for the treatment of tardive dyskinesia

They elevate plasma prolactin and produce Parkinsonian symptoms

All drugs are equally potent for treatment of psychosis

The drugs are primarily indicated for obsessive compulsive disorder

The drugs are useful in patients with cognitive impairment

Atypical antipsychotic drugs are thought to exert their effects through both dopamine D2 receptors and 5HT2A receptors. This seems to endow them with some beneficial properties compared to the typical agents. However there are some side effects. The most concerning of these is which of the following?

Substantial weight gain in some patients

Parkinsonian symptoms

Dry mouth and blurred vision

Elevation of prolactin secretion

No effect on the negative symptoms of schizophrenia

Receptors are proteins often found on the cell surface. They can be divided into two main types, one being G protein coupled. What is the other?

The primary goal in the treatment of Parkinson’s Disease is to restore dopamine function. How is this accomplished in clinical practice?

By using the precursor of dopamine synthesis L-DOPA

By prevention of dopamine break down with metabolism inhibitors such as MAO-B and COMT inhibitors

By the use of dopamine agonists

Using anti-cholinergic agents

All of the above methods alone or combination are frequently used

Commonly receptors are located on pre-synaptic neurons. What is the primary function of such receptors?

They have no direct physiological function

They receive input from different neurotransmitters than that of the primary neuron

They function as a so-called auto-receptor control their own synthesis

They control the function of glial cells

They have a role in regulating neurotransmitter transporter molecules

Consider the set of dose response curves for a series of drug acting at a receptor as shown below. With respect to these three compounds which of the following statements is correct?

Drug X is more potent than either Y or Z

Y is a full agonist

X and Z are equipotent

X has greater efficacy than Z

The maximum efficacy of Y is greater than Z

Which of the following enzymes is regarded as rate limiting for the synthesis of dopamine?

Aromatic amino acid decarboxylase

Monoamine oxidase (MAO)

Catechol – O - methyl transferase (COMT)

Dopamine – β - hydroxylase

Tyrosine hydroxylase (TH)

In recent years the so called “atypical” or second generation antipsychotic drugs have been introduced for the treatment of schizophrenia. Which statement best characterises the difference between typical or first generation and atypical antipsychotic medications?

Atypicals are characterised by less EPS symptoms and little or no tardive dyskinseia

Atypical antipsychotic drugs are not as effective as typicals

Typical antipsychotic drugs never cause Parkinson like symptoms

Typical antipsychotic drugs do affect the secretion of prolactin

Atypical antipsychotic drugs do not affect dopamine D2 receptors

Drugs acting as agonists and antagonist at dopamine D2 receptors are characterised by markedly different physiological responses. Thus a compound such as bromocriptine which is a dopamine D2 agonist, if administered would likely result in which of the following actions?

Prevention of nausea

Relief of the symptoms of schizophrenia

Suppression of prolactin secretion

Induction of an extrapyramidal syndrome

Cause anxiety attacks

Which of the following can be classified as an inhibitory amino acid neurotransmitter?

Which of the following can be classified as an excitatory amino acid neurotransmitter?

Parkinson’s disease is a specific neurological disorder resulting from a loss of dopamine neurons in the substantia nigra. A model of the disorder has been developed based on lesioning studies with the specific neurotoxin MPTP. This agent must be bioactivated by the enzyme monoamine oxidase (MAO) to form MPP+ before its effects are apparent. Which of the following statements are true?

There is no effective way of protecting against the effects of MPTP.

MAO inhibiting drugs afford full protection against MPTP

Neuronal dopamine uptake blockers offer no protection against MPTP

Increasing the activity of MAO should offer a neuroprotective strategy

The damage to neurons can be reversed by treatment with antidepressants

Tardive dyskinesia and other extrapyramidal syndromes have most often been associated with the use of which type of psychotropic medications?

Depending on whether they act as agonists or antagonists at dopamine D2 receptors some drugs may be used to suppress the symptoms of Parkinson’s disease (agonists) or may cause Parkinsonian like symptoms (antagonists). Which of the following statements could also be used to distinguish D2 agonists from D2 antagonists?

D2 agonists and D2 antagonists can cause vomiting

Binding of the agonists and the antagonists to the D2 receptor stimulates adenylate cyclase activity

D2 agonists suppress and D2 antagonists increase prolactin secretion

D2 agonists are effective antipsychotic drugs but antagonists are not

None of the above

Neurotransmitters are released from pre-synaptic nerve terminals by two processes. One is diffusion, what is the other?

The dopamine hypothesis of schizophrenia is based mainly on the mechanism of action of antipsychotic drugs. Some additional clinical observations also support the idea. Which of the following could be considered as support for the hypothesis?

High doses of the drug L-DOPA worsen psychotic symptoms

Amphetamines exacerbate the positive symptoms of the disorder

Dopamine agonists may exacerbate the symptoms

Drugs which inhibit the enzyme dopamine-β-hydroxylase also worsen the symptoms

All of the above.

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