Pharmacology
Which type of drug name usually begins with a lowercase letter?
Brand name
Code name
Generic name
Trade name
The federal body that determines whether a drug is considered a controlled substance and to which schedule it belongs is the
Food and Drug Administration (FDA).
Federal Trade Commission (FTC).
Drug Enforcement Administration (DEA)
U.S. Pharmacopeia (USP).
The abbreviation used on prescriptions for four times a day is
Bid.
Qid
Qd.
Ud.
In comparing two drugs, the dose-response curve for the drug that is more efficacious would
Be closer to the y-axis
Be farther from the y-axis
Have a greater curve height
Have a higher median effective dose (ED ).
When different drugs compete for the same receptor sites, the drug with the stronger affinity for the receptor will bind to
More receptors than the drug with the weaker affinity
Fewer receptors than the drug with the weaker affinity.
All of the available receptors.
None of the available receptors
When the acidity of the tissue increases, as in instances of infection, the effect of a local anesthetic decreases
True
False
The distribution of a drug is determined by
Blood flow to the organ
Presence of certain barriers.
Plasma protein–binding capacity
Solubility of the drug.
All of the above
The _____ is the most common site for biotransformation.
Kidney
Liver
Blood plasma
Small intestine
If a drug displays zero-order elimination kinetics
Elimination increases as the dose of the drug is increased.
A constant amount is eliminated per unit time.
The drug is not eliminated and is retained in the body.
The elimination of the drug cannot be predicted mathematically.
Which organ is involved in the first-pass effect after oral administration of a drug?
Kidney
Lungs
Liver
Spleen
Which of the following routes of drug administration produces the most rapid drug response?
Intravenous
Intramuscular
Subcutaneous
Intradermal
A drug effect that is neither predictable nor dose related is called a
Therapeutic effect.
Toxic reaction.
Side effect.
Drug allergy
Drug allergy
An acute, life-threatening allergic reaction characterized by hypotension, bronchospasm, laryngeal edema, and cardiac arrhythmias is what type of hypersensitivity?
Type I
Type II
Type III
Type IV
Etracycline, nonsteroidal antiinflammatory drugs (NSAIDs), and the benzodiazepines are safe to administer to a pregnant patient.
True
False
In an assessment of drug action for a certain therapeutic agent, results indicate that the ED is 3 mg/kg, and the LD is 300 mg/kg. What is the therapeutic index for this agent?
3
300
0.01
100
The autonomic nervous system (ANS) functions as a(n) _____ system for many bodily functions.
Somatic negative feedback
Somatic modulating
Automatic negative feedback
Automatic modulating
The acronym SLUD denotes adverse reactions associated with administration of _____ agents.
Cholinergic
Anticholinergic
Adrenergic
Antiadrenergic
Which drug would be best to treat xerostomia?
Atropine
Propranolol
Pilocarpine
Pseudoephedrine
Agents such as albuterol (Proventil, Ventolin) cause bronchodilation by binding to _____ receptors.
Alpha
Beta1
Beta2
Nicotinic
Which of the following agents is being used to produce methamphetamine?
Phenylephrine
Pseudoephedrine
Dopamine
Dipivefrin
The fight-or-flight response refers to activation of the parasympathetic nervous system in response to stress.
True
False
Which of the following raises the pain threshold?
Emotional instability
Empathy
Sleep
B and C
A and C
Nonopioid analgesics act primarily at the peripheral nerve endings, although their antipyretic effect is mediated centrally
True
False
The action of nonopioid analgesics is related to their ability to inhibit
The CNS.
Prostaglandin synthesis
Release of epinephrine.
Release of acetylcholine.
Which of the following choices has antiinflammatory, antipyretic, analgesic, and antiplatelet action?
Acetaminophen
Codeine
Aspirin
Hydrocodone
A drug interaction between aspirin and _____ can result in significant bleeding
Probenecid
Warfarin
Methotrexate
Sulfonylureas
Which of the following NSAIDs is considered the drug of choice for management of dental pain when a NSAID is indicated?
Naproxen
Naproxen sodium
Ibuprofen
Diflunisal
Acetaminophen does not possess any of these clinically significant _____ effects: (1) antipyretic, (2) antiinflammatory, (3) analgesic.
1, 2, 3
1 and 2
1 and 3
1
2
Alcohol consumption stimulates the breakdown of acetaminophen, thereby increasing the toxic potential of acetaminophen use.
True
False
Which of the following agents is intended to treat an acute attack of gout?
Probenecid
Codeine
Colchicine
Acetaminophen
Both A and C
Aspirin should not be given to a child until he or she is 18 years of age because
The tablets are too difficult to swallow
There is a risk of Reye syndrome.
Aspirin is a narcotic and requires a prescription
Aspirin has been associated with hepatotoxicity
What do aspirin, acetaminophen, ibuprofen, and codeine have in common?
They are all antiinflammatory.
They are all analgesic.
They all inhibit platelet aggregation
They are all antipyretic
Which opioid is commonly used as an antitussive?
Propoxyphene
Codeine
Diphenoxylate
Pentazocine
______________is usually the cause of death with an overdose of opioid analgesics
Tachycardia
Respiratory depression
Electrolyte imbalance
Cellular necrosis
Which of the following drugs can be used to treat heroin addiction?
Hydromorphone
Methadone
Naltrexone
Both A and C
Both B and C
Tylenol #3 contains _____ mg of codeine.
7.5
15
30
60
If an infection is just beginning, the organisms most likely to be present are
Gram-positive cocci
Gram-negative cocc
Gram-positive anaerobes
Gram-negative anaerobes
Which of the following agents is the drug of choice for an early dental infection unless the patient is allergic to it?
Erythromycin
Clindamycin
Penicillin
Metronidazole
Which of the following antibiotics is associated with pseudomembranous colitis?
Penicillin
Erythromycin
Clindamycin
Metronidazole
Superinfection is more often caused by _____-spectrum antibiotics and increases when taken for a _____ time period.
Narrow; shorter
Narrow; longer
Broad; shorter
Broad; longer
_____ has the highest incidence of gastrointestinal complaints of any of the antibiotics.
Penicillin
Erythromycin
Clindamycin
Cephalosporin
A cephalosporin would be most closely related to which of the following agents?
Penicillin VK
Clarithromycin
Ciprofloxacin
Doxycycline
Tetracyclines should not be used in children younger than _____ years of age.
16
9
12
15
_____ can cause black pigmentation of mandibular and maxillary alveolar bone and the hard palate.
Penicillin V
Erythromycin
Minocycline
Clindamycin
The standard antibiotic drug regimen prior to dental procedures requiring immunoprophylaxis in a patient with no allergies to penicillin or amoxicillin is _____ g of amoxicillin _____ hour(s) before the procedure
1; 1
1; 2
2; 1
2; 2
Nystatin is used for both the treatment and the prevention of _____ in susceptible cases.
Blastomycosis
Histoplasmosis
Oral candidiasis
Tinea
Viruses are difficult to treat because to kill the virus the host's cells must also be harmed.
True
False
A person with hepatitis _____ is most likely to develop chronic hepatitis.
A
B
C
D
Topical acyclovir can prevent the recurrence of herpes labialis
True
False
Addition of vasoconstrictor to local anesthetic (1) reduces blood supply to the area, (2) increases blood supply to the area, (3) limits systemic absorption, (4) increases systemic absorption, (5) reduces systemic toxicity, and (6) increases systemic toxicity. Which of these are correct?
1, 3, 5
1, 4, 5
2, 3, 5
2, 3, 6
2, 4, 6
Amide local anesthetics are metabolized
By being hydrolyzed by plasma pseudocholinesterases.
Primarily by the liver.
In the spleen.
Minimally and are excreted virtually unchanged
Which of the following local anesthetics is safest to use for dental treatment for a pregnant woman?
Mepivacaine
Lidocaine
Articaine
Bupivacaine
The maximum safe dose of epinephrine for the cardiac patient is _____ mg.
0.02
0.04
0.2
0.4
Which dental anesthetic is an ester?
Lidocaine
Mepivacaine
Prilocaine
Bupivacaine
Benzocaine
Which of the following local anesthetics in a dental cartridge has the longest duration of action?
0.5% Marcaine
2% Lidocaine
3% Mepivacaine
4% Articaine
A patient can produce endogenous epinephrine far in excess of that administered in dentistry in the presence of inadequate anesthesia.
True
False
Nitrous oxide, as used in the dental office, maintains the patient in stage _____ of Guedel’s system of stages and planes.
I
II
III
IV
Which of the following agents are the most commonly prescribed type of antianxiety drugs?
Nonbenzodiazepine-nonbarbiturate sedative-hypnotics
Nonbenzodiazepine-nonbarbiturate receptor agonists
Benzodiazepines
Barbiturates
The use of barbiturates is absolutely contraindicated in patients with a positive family history of
High blood pressure.
Diabetes
Porphyria.
Adrenal insufficiency.
Each of the following conditions is an absolute contraindication to dental treatment until a consultation with the patient’s medical provider has determined any special treatment alterations that might be warranted except one. Which is the exception?
Chronic, stable angina
Uncontrolled heart failure
Uncontrolled arrhythmia
Significant, uncontrolled hypertension
How long should a person who has had a myocardial infarction wait before receiving dental care?
2 weeks
2 months
6 months
12 months
24 months
Dental patients with left heart failure may need to be positioned in the dental chair
With their left hip elevated.
With their right hip elevated.
In a semireclined position.
With their feet at a higher elevation than their head.
Lying flat.
Which of the following is the primary type of drug recommended for patients who have edema or fluid retention with heart failure (HF)?
Angiotensin-converting enzyme inhibitor
Angiotensin receptor antagonist
Beta-blocker
Aldosterone antagonist
Diuretic
Hypersalivation is a sign of toxicity for which of the following agents?
Clonidine
Digoxin
Enalapril
Hydrochlorothiazide
Nifedipine
The use of nitroglycerin (NTG) is contraindicated if sildenafil (Viagra) has been administered within 24 hours. This is because the NTG-sildenafil combination can precipitate a hypotensive crisis.
True
False
Which of the following groups of diuretics are called the “puny” diuretics?
Thiazide
Loop
Potassium-sparing
Both A and B
Both B and C
Many _____ end in the suffix -pril
β-adrenergic blockers
Calcium channel blockers
Angiotensin-converting enzyme inhibitors (ACEIs)
Angiotensin receptor blockers (ARBs)
Angiotensin receptor blockers (ARBs) end with the suffix
-olol.
-dipine.
-pril
-artan.
Each of the following agents is associated with development of gingival hypertrophy except one. Which is the exception?
Verapamil
Phenytoin
Clonidine
Dilantin
Which antihypertensive agent is associated with a nonproductive cough?
Angiotensin receptor blocker
Beta-adrenergic blocking agent
Alpha1-adrenergic blocking agent
Angiotensin-converting enzyme inhibitor
Most dental procedures do not require a change in the dose of warfarin.
True
False
Which of the following is the most common gastrointestinal disease in the United States population?
Peptic ulcers
Gastroesophageal reflux disease (GERD)
Diarrhea
Constipation
Ulcerative colitis
Which of the following types of drugs is considered first-line therapy for treatment of irritable bowel syndrome (IBD)?
Antibiotic
Antacid
Antidiarrheal
Antiinflammatory
Which of the following statements is true concerning epilepsy?
Epileptic seizures can be recorded on electrocardiogram.
Seizure activities are estimated to affect approximately 10% of the population.
The majority of epileptic patients have idiopathic epilepsy.
The most common generalized seizures are temporal lobe (psychomotor).
Seizures characterized by a duration for longer than 30 minutes are called _____ seizures.
Akinetic
Complex
Status epilepticus
Myoclonic
Simple (Jacksonian)
Which antiepileptic agent is commonly prescribed for trigeminal neuralgia?
Lamotrigine
Phenytoin
Carbamazepine
Valproic acid
Gingival enlargement as a consequence of phenytoin therapy most commonly affects the _____ facial gingiva.
Maxillary anterior
Maxillary posterior
Mandibular anterior
Mandibular posterior
Which of the following psychiatric disorders involves a loss of the perception of reality?
Bipolar affective disorder
Schizophrenia
Panic disorder
Obsessive-compulsive disorder
Interaction of monoamine oxidase inhibitors (MAOIs) with many drugs such as amphetamines, and with foods such as wines, cheese, and fish, can precipitate
Hair loss
Hypertensive crisis.
Gout
Dysgeusia.
Second-generation antipsychotics have fewer side effects than firstgeneration antipsychotics.
True
False
Adrenocorticosteroids are released from the
Hypothalamus.
Adrenal cortex
Pituitary gland
Kidney.
The most extensive use of the corticosteroids in both medicine and dentistry is in
Replacement therapy for corticosteroid deficiency.
Cancer chemotherapy
To prevent organ transplant rejection
Osteoporosis
Inflammatory and allergic conditions.
Levels of endogenous corticosteroids can increase tenfold in response to an especially stressful stimulus.
True
False
Most dental patients taking steroids who are having normal dental treatment rendered do not need additional corticosteroids.
True
False
Asthma is characterized by _____ airway obstruction and is associated with reduction in _____ airflow.
Reversible; inspiratory
Reversible; expiratory
Irreversible; inspiratory
Irreversible; expiratory
Patients with asthma should bring their fast-acting _____ inhaler to be used prophylactically or in the management of an acute asthmatic attack in the dental office.
μ-agonist
β1 -agonist
β1 -antagonist
β2 -agonist
The drug of first choice for emphysema is
Albuterol.
Zileuton.
Theophylline.
Beclomethasone.
Ipratropium.
Which of the following common antihistamines produces the most sedation?
Brompheniramine (Dimetane)
Diphenhydramine (Benadryl)
Fexofenadine (Allegra)
Loratadine (Claritin)
Montelukast (Singulair) is a(n)
Intranasal corticosteroid.
Leukotriene modifier
Intranasal anticholinergic drug.
Mast cell stabilizer
Oral decongestant.
Why should intranasal decongestants only be used for 3 to 5 days?
They produce systemic toxicity.
They can cause rebound congestion.
They will start to cause systemic autocoid effects.
They will produce xerostomia
Insulin is usually administered
Orally.
By subcutaneous injection.
By intramuscular injection.
By intravenous injection.
The most common adverse reaction associated with any insulin product is
Hypoglycemia
Hyperglycemia
Intestinal stasis.
Bradycardia
Which is considered first-line therapy for a patient with type 2 diabetes?
Diet and exercise
Glucagon
Oral antidiabetic agents
Insulin
Hormonal contraceptives have the potential to cause or aggravate gingival inflammation.
True
False
The majority of cases of osteonecrosis have been reported in patients with cancer who are receiving _____ bisphosphonates.
Oral
Intravenous
Intramuscular
Subcutaneous
The pregnant dental patient is most comfortable during which trimester?
First trimester
Second trimester
Third trimester
None of the above
Which of the following statements is true of the use of nystatin in either a pregnant woman or a nursing infant?
Nystatin may be used by either a pregnant woman or a nursing infant
Nystatin may be used by a pregnant woman, but not by a nursing infant.
Nystatin may be used by a nursing infant, but not by a pregnant woman
Nystatin is not to be used by either a pregnant woman or a nursing infant.
Which of the following choices is the most common cause of intrinsic acid production?
Medication
Gastric reflux
Wine
Ciders
The majority of desensitizing toothpastes contain
NaF.
Oxalates
Adhesives and resins
5% potassium nitrate.
Topical NaF 2% is recommended for patients with porcelain or composite restorations.
True
False
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