MCB MPC
How many nuclear chromosomes do human cells contain?
Somatic cells contain 46 chromosomes; gamates 23 chromosomes
Somatic cells contain 24 chromosomes; gamates 12 chromosomes
Somatic cells contain 48 chromosomes; gamates 24 chromosomes
Somatic cells contain 48 chromosomes; gamates 48 chromosomes
Which statement is correct concerning chaperones?
Chaperones only assist folding of misfolded protein
Chaperones assist protein folding in the ER and cytosol
Chaperones assist folding of protein exclusively in the ER
Chaperones assist folding of all proteins
Which statement is true?
DNA contains a sugar ribose
RNA normally contains the bases T C A G
RNA can normally adopt distinctive folded shapes
RNA is mainly found as a long, double-stranded molecule
Which of the following is NOT a role of molecular chaperones in the folding of cellular protein
They specify the final 3D shape of proteins
They assist proteins in folding into their correct conformations
They help prevent formation of protein aggregates
They catalyze the folding of proteins in the crowded environment of the cell
Which statement is correct?
Protein are imported into mitochondria co-translationally
Proteins are imported into the nucleus via vesicular trafficking
Proteins are imported into endosomes via vesicular trafficking
Proteins are imported into the ER post-translationally
Type II integral membrane proteins:
Contain a single transmembrane segment with the N-terminal region located in the ER lumen. The transmembrane segment is integrated in the membrane during its translation
Contain a single transmembrane segment with the N-terminal region located in the ER lumen. The transmembrane segment is integrated in the membrane after its translation
Contain a single transmembrane segment with the N-terminal region located in the cytosol. The transmembrane segment is integrated in the membrane during its translation
Contain a single transmembrane segment with the N-terminal region located in the cytosol. The transmembrane segment is integrated in the membrane after its translation
Which 2 processes are outcomes of protein ubiquitination?
Exocytosis and endocytosis
Proteasomal degradation and mitochondrial import
Endocytosis and mitochondrial import
Proteasomal degradation and endocytosis
Proteins Rho, Rac and Cdc42 are:
All of the listed answers are correct
Switched on by GEFs that exchange GDP into GTP
Switched off by GAPs that exchange GTP for GDP
Recruited to the plasma membrane by GDI
Which statement is correct?
Selectins bind weakly to carbohydrates
Selectins bind strongly to carbohydrates
Selectins bind weakly to collagen
Selectins bind strongly to collagen
Without regulation by other proteins, F-actin filaments in cells with physiological concentrations of G-actin would:
Grow on the minus-end, shrink on the plus-end
Shrink on the minus-end, shrink on the plus-end
Shrink on the minus-end, grow on the plus-end
Grow on the minus-end, grow on the plus-end
The ECM in the basal lamina is mainly composed of:
Type X collagen
Type IV network forming collegen
Type I ribola collagen
Type X XXXXXX collagen
Vague question:Which statement regarding glycosaminglycarbxxx in extracellular matrix
They are strongly hydrophilic and xxxx large amount of water
X
X
X
Rab5 is a small GTPase involved in vascular trafficking:
Rab5 binds to membranes on early endosomes in its GTP-bound form and recruits endocytic vesciles from the PM
X
Proteins are generated in the ER and trafficked to different ogranelles. In which organelle does this sorting take place?
Cis-Golgi network
Lysomes
Trans-Golgi network
Medial Golgi-network
Low density lipoprotein (LDL) is a cholesterol-binding protein that sequesters lipid protein particles in the blood and its subsequently endocytosed. Which statement is true?
LDL binds to the LDL-receptor and is taken up via macropinocytosis
LDL is phagocytosed after binding to the LDL receptor
LDL-receptors are present in caveolae and subsequently endocytosed
LDL binds the LDL-receptor at the PM and its endocytosed in a clathrin-depended manner
Innate immunity is the first line of defense. Which cells are involved in this defense?
Helper T-cells
B-Cells
Cytotoxic T cells
Macrophages
Cross presentation is an antigen presentation process that is a hallmark of dendritic cells. What is cross-presentation?
The presentation of self-antigens on MHC-II
The presentation of foreign-antigens on MHC-II
The presention of foreign-antigens on MHC-I
The presentation of self-antigens on MHC-I
Dendritic cells sample antigens and activate T cells. Where does this activation take place?
Thymas
Lymph nodes
Peripheral tissue
Bone marrow
Which of the following features of DNA underlies its simple replication procedure?
The fact that it is copmosed of only four different types of bases
The antiparallel arrengement of the double helix
The complementary relationship in the double helix
The fact that there is a major groove and a minor groove in the double helix
Select the statement which are correct: (Multiple answers)
Due to nucleosomes binding, DNA takes up more space in the nucleus
Each chromosome has multiple origins of replication
Chromatin compaction can be regulated by modifying the histone tails
Between Adenine and Thymine more hydrogen bonds are formed than between Guanine and Cytocine
DNA replication image: Which discribed the figure correctly?
The Helicase III rewinds the DNA after succesful translation by the DNA polymeraseB1
The RNA polymerase B1 runs into the single stranded binding protein II, before it hits the ligase III and is finished
The ligase VI reads out if the bases placed by the DNA polymerase B2 are correct and removes any incorrect bases
The RNA primer V is necessary to allow the DNA polymerase B2 to synthesise the primer strand
Telomeres have a specific t loop structure. Why is this structure needed?
To make this region easy to find for microtubules during mitosis
To prevent DNA repair
To make the DNA available for transcriptoin
To copmact the DNA even further
5' 3' double yellow + single blue inside blue potato: What enzyme is depicted in the drawing?
Reverse transcriptase
RNA polymerase
DNA polymerase
Topoisomerase
Ribosome
Indicate when it occurs: G phase, S phase, G2 phase or all
ORC phosphorylation
S
DNA helicase activation
G
Licensing of replication origins
G
DNA helicase deposition on DNA at the replication origins
S
Select the right answers (Multiple right)
To prevent inflammation reactions, apoptosis does not cost energy
Apoptosis, in contrast to necrosis, does not lead to inflammation
A trigger for apoptosis results in the activation of initiator caspases, which than function to activate executioner caspases
Only executioner caspases cleave proteins
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