PHA 3112 MIDTERM PRACTICE
PHA 3112 Midterm Practice Quiz
Prepare yourself for the PHA 3112 Midterm with this comprehensive practice quiz! Test your knowledge on pharmacokinetics, drug interactions, and routes of administration. This quiz includes 37 questions that cover key aspects of pharmacology.
- Multiple Choice Questions
- Rank and Checkbox Formats
- Relevant Drug Knowledge
Which of the following are NOT considered a drug?
Perscriptions
Blood products
Disinfectants
Natural Health Products
All of the above are drugs
Pharmacokinetics studies how the body acts on the drug, order how the drug progresses through the body
Absorption
Distibution
Metabolism
Elimination
Which is correct considering N-acetyl-p-aminophenol
This is the generic name
This is the chemical name
This is the brand name
This is the trade name
Non of the above are correct
Match the abbreviation with its meaning: b.i.d
Twice a day
Before meals
Four times a day
At bedtime
Match the abbreviation with its meaning: ad lib
As much as needed
As much as desired
Before bedtime
Before meals
Match the abbreviation with its meaning: h.s
Before bedtime
Before meals
As much as desired
Four times a day
Which are examples of tropical routes of administration
Nasal sprays
Inhalation
Skin Creams
Ointments
Eye Drops
Which of the following is the most common route of administration?
Oral
Tropical
IV
Sublingual
What is F when injecting a drug through IV?
1
0.5
0.9
0.1
Not enough information given
Which form of administration is best used when someone has nausea or vomiting?
Bucco-gingival
Rectal
Oral
Sublingual
Which is a technique in which the bone marrow is used to administer the drug
Intraosseus
Intraossical
Intrafemoral
Intrablast
Why does the IV route require extra vigilance?
High Concentrations
Phlebitis
Air embolisms
Extravascular administration
When using the oral route F will = <1
True
False
Which are NOT factors that will increase bioavailability?
Slow gastric motility
Decrease in intestinal motility
Inflammation of the intestinal wall
Ergometrine is a weak base with a pka of 6.9, In what form will this drug be found when it is in the duodenum where the pH=5.2?
Drug will be more in "B" form that is not absorbable
Drug will be more in "BH+" form which is absorbable
Drug will be more in "B" form that is absorbable
Drug will be more in "BH+" form which is not absorbable
Asprin is a weak acid with a pka of 3.5, In what form will this drug be found when its in the stomach with a pH of 3
Drug will be more in "A-" form that is absorbable
Drug will be more in "HA" form that is absorbable
Drug will be more in "A-" form that is not absorbable
Drug will be more in "HA" form that is not absorbable
A patient is being given a drug and it has a warning for a potential interaction with food, what should the pharmacist advice to the patient taking the medication?
Take 30 min before or 1-2 hour after meal
Take 1 hour before or 2-3 hours after meal
Take 1 hour before or 30min-1 hour after meal
Take 3 hours before or with the meal
Which of the following can affect the range of distribution
Lipid solubility of the drug
Weather the drug is bound to plasma protein or accumulates in tissues
The blood flow to organs relative to size
The way drug was administered
Interactions of plasma proteins with drugs are...
Low affinity and High capacity
Low affinity and Low capacity
High affinity and Low capacity
High affinity and High capacity
If tissue binding is high then
Volume distribution will be low
Volume distribution will be high
No change to volume distribution
Which are the primary ways a drug moves across a cell membrane?
Passive diffusion
Active transport
Facilitated diffusion
Endocytosis
Which are the only substances that can cross blood brain barrier?
Uncharged drug
Lipid soluble drugs
Charged drugs with a corresponding transport protein
Small drugs
Which phase during drug metabolism is a reactive group added?
Phase II
Phase I
Phase III
Phase IV
The result of a sometimes inactive, mostly water soluble compound is the result of which phase?
Phase II
Phase I
Phase III
Phase IV
Which are part of the cytochrome p 450 family?
CYP 2E1
CYP 1A2
CYP 3A4
CYP 2A1
CYP 2D6
CYP 2C19
CYP 2A4
CYP 2B6
Name the inducer with the correct enzyme
Cigarette smoke - CYP 1A2
Phenytoin - CYP 3A4
Rifampin - CYP 2C9
Cigarette smoke - CYP 3A4
Rifampin - CYP 2C19
Grapfruit - CYP 3A4
Ketoconazole - CYP 1A2
Erythromycin - CYP 2D6
Name the inhibitor with the correct enzyme
Cigarette smoke - CYP 1A2
Phenytoin - CYP 3A4
Rifampin - CYP 2C9
Cigarette smoke - CYP 3A4
Grapfruit - CYP 3A4
Erythromycin - CYP 2D6
Ketoconazole - CYP 3A4
Erythromycin - CYP 3A4
Inducers are to _____ where Inhibitors are to _____
Chronic, Acute
Acute, Chronic
Inducers decrease therapeutic levels whereas inhibitors result in accumulation of a drug
True
False
How many half life's does it take to eliminate 95% of a drug?
1-2
3-4
4-5
5-6
The peak and trough levels are increased as the number of administrations per day increases
True
False
Steady state doesn't depend on the dose but instead depends on the half life of the drug
True
False
What would you do if the waiting for the drugs 4-5 half life was too long?
Wait
Administer a loading dose
Give them 4 pills instead of one
A patients drug levels were 10mmol/L, well over the therapeutic range of 0.7-2.2mmol/L. This drug has a half life of 2hrs, how long would the patient need to withhold taking the medication before plasma levels are back in therapeutic range?
4 hours
6 hours
2 hours
8 hours
How many half live's would it take for the medication to return to its steady state after missing only ONE dose?
4-5
1-2
Missing a dose doesn't effect the steady state
5-6
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