Quiz on genomic in pregnancy

According to the Modified World Health Organization (mWHO) 2.0 classification, what is the maternal cardiovascular risk of a 30-year-old woman with genotype-positive arrhythmogenic right ventricular cardiomyopathy (ARVC) and a mild phenotype?

mWHO I – No detectable increased risk of maternal mortality or morbidity

mWHO II – Small increased risk of maternal mortality or morbidity

mWHO II–III – Moderate increased risk depending on individual factors

mWHO III – Significantly increased risk of maternal mortality or morbidity; expert counseling required

mWHO IV – Extremely high risk of maternal mortality or severe morbidity; pregnancy contraindicated

When counselling women or couples with a known parental monogenic or chromosomal abnormality, which of the following is required for pre-implantation genetic testing?

Which genetic variant is most frequently identified in women with peripartum cardiomyopathy (PPCM)?

Among genetic carriers without a dilated cardiomyopathy (DCM) phenotype before pregnancy, what proportion developed DCM during or shortly after pregnancy?

Which type of complication was the most frequent cardiac event in women with overt DCM during pregnancy?