Drug Effects on the EEG

Sedating TCAs like Amitriptyline (Elavil) and imipramine (Tofranil) increase theta and fast-beta power and decrease alpha and total power.

Chlorpromazine (Thorazine), a sedating FGA, increases EEG coherence, reduces total power, increases delta and theta power, and reduces alpha and beta power.

Benzodiazepines do not increase delta or theta power.

Amphetamine (Adderall) reduces total power and reduces absolute delta, theta, alpha, and beta power.

Immediately after morphine administration, during the euphoric high, alpha power increases, and the peak alpha frequency slows.