Pathology
1- Which of the following is the most common cause of cancer-related deaths in females as
Leukemia
Breast
Lung
Gastric
Colorectal
Dysplasia is:
Hypertrophic growth
Hypotrophic growth
Increased growth
Disorderly growth
Neoplastic growth
Which of the following isn’t an effect of transforming growth factor beta
Inhibitor of most epithelial cells and leukocytes
Stimulates fibrosis
Increases proteases and inhibits protease inhibitors
Strong anti-inflammatory effect
Stimulates proliferation of fibroblasts & smooth muscles
Which of the following isn’t component of the interstitial matrix
Fibronectin
Laminin
Fibrillary and nonfibrillar collagen
Elastin
Proteoglycans
Ewing sarcoma is characterized by the following:
T (9:22)
Her2 neu amplification
T (11:22)
T (8:14)
T (14:18)
Which of the following chemical mediators is a vasoactive amine and its
Nitric oxide
Histamine
Thromboxane A2
Prostacyclin
Serotonin
The neoplasm is a metastasis
The patient is probably cured of the cancer
The patient has poorly differentiated neoplasm
The stage of the neoplasm is low
A paraneoplastic syndrome is likely
The complement systems is inactivated by which of the following
Kallekrin
Plasmin
Bacteria containing mannose-binding receptor (lectin pathway)
Decay activating factor
Antigen antibody complex
Which of the following is usually a mixed tumor
Breast carcinoma
Teratoma arising in the ovary of a 30 year old female
A mass of pancreatic islet cells in the wall of ileum
Carcinoma arising in the colon of a patient with multiple polyposis
Rhabdomyosarcoma in the urinary bladder
Stem cells are characterized by all of the following except
Replication into two daughter stem cells
Self-renewal capacity
Asymmetric replication
Extensive proliferative potential
Capacity to develop into multiple lineages
Requirements for tissue to repair by regeneration include all of the
Intact basement membrane
Cellular proliferation , regulated by growth factors and growth inhibitors
Permanent cells
Extracellular matrix (ECM) & cell matrix interaction
Replacing injured tissue by same type of original tissue
Phospholipase A2 causes the release of which of the following chemical
Nitric oxide
Platelet activating factor PAF
Hageman factor
Histamine
Bradykinin
Patient born with genetic defect in CD18 unit of integrin will develop:
Chronic granulomatous disease
Angioneurotic edema
Leukocyte adhesion deficiency 1
Leukocyte adhesion deficiency 2
Chediak-hegashi disease
How does VEGF affect an endothelial cell:
Increase proliferation
Increase permeability
Increase migration
Increase differentiation
All of the mentioned options are correct
HER2 neu gene rearrangement in breast carcinoma is usually mediated
Translocation
Deletion
Gene amplification
Chromosomal gain
Point mutation
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