Biologics
What are the components needed for bone formation (that are also characteristics of autograft)?
Osteoconductive
Osteostimulative
Osteogenic
Osteoinductive
Osteproductive
Which of the following is correct regarding bone remodeling?
Activation – osteoprogenitor cells differentiate into osteoclasts
Resorption – osteocytes resorb old bone
Formation – osteoblasts build new bone
All of the above
Signify what sizes are available?
1cc, 5cc, 10cc
2cc, 8cc, 10cc
2cc, 5cc, 10cc
1cc, 2cc, 5cc
Signify contains how much of Bioglass?
72%
80&
84%
92%
Kinex strips are cross-linked to add___.
Bone formation
Strength
What is Signify composed of?
Bioglass Hyaluronic Acid, Glycerol
Bioglass, Polyethylene glycol (PEG), Glycerol
Signify is radiopaque
True
False
Which Signify Products are indicated to be used in the posterolateral spine?
Signify Crunch
Signify Putty
Signify Gel
All of the above
Which Signify Product(s) are indicated to be used in the extremities and pelvis?
Signify Crunch
Signify Putty
Signify Gel
Signify is classified as…
Allograft
Synthetic
Autograft
Signify requires preparation before use.
True
False
What are Osteoblasts responsible for during bone remodeling?
Bone building
Resorb old bone
Differentiate into osteoclasts
Which of the below „osteo“ words describe Bioglass?
Osteoinductive
Osteoconductive
Osteostimulative
Osteogenic
XEMPLIFI DBM provides an osteoconductive scaffold with Osteoinductive potential.
True
False
Every LOT of XEMPLIFI DBM is tested for Osteoinductive potential after sterilization.
True
False
What is the benefit of the larger sized cancellous chips in XEMPLIFI DBM plus?
Osteogenic factors
Additional natural scaffolding
More strength
Osteostimulative
Which synthetic products should be mixed with BMA prior to implantation?
KINEX
Signify
XEMPLIFI DBM
KINEX Plus
What is XEMPLIFI DBM Putty composed of?
Bioglass, hyaluronic acid, temperature sensitive hydrogel
Demineralized bone matrix, Temperature sensitive hydrogel
Bioglass, hydroxy apatite, hyaluronic acid
Bioglass, temperature sensitive hydrogel, Hyaluronic acid
Which form of SIGNIFY is most visible on X-ray compared to the other?
Gel
Putty
Crunch
Choose the description that is correct.
Signify Putty contains a mixture of Bioglass sizes (large & small), Bioactive Product
Signify Crunch contains small Bioglass Particels, Osteogenic
Signify Crunch contains a mixture of Bioglass particels (large & small), Bioactive product
Signify Gel contains small Bioglass particles, Osteogenic product
What is an example of Bioactive product?
DBM
Temperature sensitive hydrogel
Bioglass
Hyaluronic Acid
What benefits does hyaluronic acid provide to KINEX and KINEX Plus?
Angiogenesis (blood vessel formation), promote early cascularization
Scaffolding - osteoconductive
Provides growth factors
Optimal handling
XEMPLIFI possesses Osteogenic potential when used with autograft.
True
False
Bioglass stimulates osteoblast proliferation
True
False
What is the benefit of the Glycerol and PEG carrier in SIGNIFY?
Provides handling characteristics to shape and mold products
Provide a scaffold
Autograft is to be considered the „Gold Standard“ of bone grafts because it is osteoconductive, Osteoinductive, AND Osteogenic.
True
False
What are some autograft limitations?
Limited amount
Requires a secondary surgical procedure to harvest
Xemplifi is…
Allograft
Autograft
Synthetic
Which of the following is correct regarding bone remodeling?
Activation - osteoprogenitor cells differentiate into osteoclasts
Resorption - osteocytes resorb old bone
Formation - osteoblasts build new bone
All of the above
What are some limitations of ICBG that ca be addressed using allograft?
Poor bone quality (smoker/elderly)
Secondary surgical site to harvest graft
Patient surgical time/post-op recovery
All of the above
The tissue is retrieved from a donor (not the patient)
Allograft
Autograft
The tissue is retrieved from the patient itself.
Allograft
Autograft
Osteogenic
Describes a material that serves as a scaffold for osteoblasts
Describes a material that contains cells that can differentiate into bone
Describes something that accelerates the bone formation process
Describes something that induces stem cells to differentiate into osteoblasts
What is the shelflife of KINEX & KINEX Plus?
4 years
6 months
2 years
1 year
How should XEMPLIFI be stored?
-30 to -70 • C
15-30•C
XEMPLIFI is required to be hydrated prior to use.
True
False
KINEX contains how many Bioglass?
84%
72%
80%
0%
KINEX Plus contains how many Bioglass?
72%
0%
84%
80%
XEMPLIFI contains how many Bioglass?
84%
0%
72%
80%
KINEX & KINEX Plus used to be mixed with BMA prior to use at what ratio?
1:2
1:1
3:1
2:1
Osteoblasts differentiate out of what stem cells?
Mesenchymal stem cells
Hematopoietic stem cells
What are osteocytes?
Cells that build new bone
Cells that resorb old bone
Mature bone cells
XEMPLIFI DBM Plus is available in what sizes?
2cc, 5cc, 10cc
1cc, 3cc, 8cc, 10cc
1cc, 5cc, 10cc
2cc, 5cc, 8cc, 10cc
What sizes does XEMPLIFI DBM Gel & Putty come in?
1cc, 3cc, 8cc, 10cc
1cc, 5cc, 10cc
2cc, 5cc, 10cc
2cc, 5cc, 8cc, 10cc
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