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Ciclofosfamide
Est un inhibiteur de topoisomerase
À une toxicité visicale
La forme Ceto est la forme active
Est administré seulement par voie intraveineuse
On reduit sa toxicité par association avec le folinate de calcium
On utilise le protocole CMF pour le cancer de la prostate
L’acroleine est responsable de la toxicité
La fosforamide Alchylante à un effet antitumoral
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