Hema review questions

Which of the following inherited leukocyte disorders is caused by a mutation in the lamin B receptor?

Which of the following inherited leukocyte disorders involves mutations in nonmuscle myosin heavy-chain IIA?

Which of the following inherited leukocyte disorders might be seen in Hurler syndrome?

Which of the following lysosomal storage diseases is characterized by macrophages with striated cytoplasm and storage of glucocerebroside?

The neutrophils in chronic granulomatous disease are incapable of producing:

Individuals with X-linked SCID have a mutation that affects their ability to synthesize:

An absolute lymphocytosis with reactive lymphocytes suggests which of the following conditions?

What leukocyte cytoplasmic inclusion is composed of ribosomal RNA?

The expected complete blood cell count (CBC) results for women in active labor would include:

Which of the following is true of an absolute increase in lymphocytes with reactive morphology?

Lymphomas differ from leukemias in that they are:

Which one of the following viruses is known to cause lymphoid neoplasms in humans?

Loss-of-function of tumor suppressor genes increase the risk of hematologic neoplasms by:

Oncogenes are said to act in a dominant fashion because:

Which one of the following is NOT one of the cellular abnormalities produced by oncogenes:

Which one of the following is an example of a tumor suppressor gene?

G-CSF is provided as supportive treatment during leukemia treatment regimens to:

Imatinib is an example of what type of leukemia treatment?

Which one of the following is FALSE about epigenetic mechanisms?

Which one of the following is NOT a source of hematopoietic stem cells for transplantation:

According to the WHO classification, except in leukemias with specific genetic anomalies, the minimal percentage of blasts necessary for a diagnosis of acute leukemia is:

Which of the following would be considered a sign of potentially favorable prognosis in children with ALL?

Signs and symptoms of cerebral infiltration with blasts are more commonly seen in:

An oncology patient exhibiting signs of renal failure with seizures after initial chemotherapy may potentially develop:

Which of the following leukemias affects primarily children, is characterized by an increase in monoblasts and monocytes, and often is associated with gingival and skin involvement?

A 20-year-old patient presents with fatigue, pallor, easy bruising, and swollen gums. Bone marrow examination reveals 82% cells with delicate chromatin and prominent nucleoli that are CD141, CD41, CD11b1, and CD361. Which of the following acute leukemias is likely?A 20-year-old patient presents with fatigue, pallor, easy bruising, and swollen gums. Bone marrow examination reveals 82% cells with delicate chromatin and prominent nucleoli that are CD141, CD41, CD11b1, and CD361. Which of the following acute leukemias is likely?

Pure erythroid leukemia is a disorder involving:

A patient with normal chromosomes has a WBC count of 3.0 3 109 /L and dysplasia in all cell lines. There are 60% blasts of varying sizes. The blasts stain positive for CD61. The most likely type of leukemia is:

SBB stains which of the following component of cells?

The cytochemical stain a-naphthyl butyrate is a nonspecific esterase stain that shows diffuse positivity in cells of which lineage?

Non-Hodgkin lymphoma can be best differentiated from reactive disorders by:

Which laboratory test is most suggestive of autoimmune hemolytic anemia in a patient with CLL?

What is the best test or method for determining if a clonal population of T cells is present in a specimen?

A rise in the lymphocyte count from 4.1 3 109 /L to 5.5 3 109 /L in a patient with monoclonal B lymphocytosis suggests:

Which test is often used to differentiate CLL from mantle cell lymphoma?

If not treated, which of the following would generally be associated with the best outcome?

What do CLL and myeloma have in common?

In Hodgkin lymphoma the Reed-Sternberg cell and _________ are malignant.

In most cases the diagnosis of lymphoma relies on all of the following except:

Which of the following is present in monoclonal gammopathy of underdetermined significance?

Produces RED BROWN GRANULES in cytoplasm of granulocytes and monocytes

Which of the following is negative to NSE

LAP Score grading: 50%-80%

Decreased LAP Grading caused by?

SBB/MPO, SE, NSE POSITIVE

Isoenzyme 5 indicates?

SBB/MPO: -, TdT: +

SBB/MPO: -, SE: -, NSE: +

Useful in diagnosis of erythroleukemia (FAB M6)