IMSE Hypersensitivity & Transplant Immunology

The immune mediator for Anaphylactic hypersensitivity reaction is "IgM"

The immune mediator for Cytotoxic hypersensitivity reaction is "IgG"

The immune mediator for Immune Complex hypersensitivity reaction is "IgE"

The immune mediator for Delayed hypersensitivity reaction is "T cells"

Antigens that trigger formation of "IgM" are called atopic antigens or allergens

Type IV Hypersensitivity reaction

Type III Hypersensitivity reaction

Type II Hypersensitivity reaction

Type I Hypersensitivity reaction

Activation Phase occurs _____ mins after exposure.

Responsible for mucus secretion

Responsible for vasodilation

Attracts eosinophils to the area and induces expression of eosinophil receptors for C3b

The following are immunologic mechanisms of Type II hypersensitivity reaction, EXCEPT?

In type IV hypersensitivity, Robert Koch observed individuals infected with ___?

Is an autoimmune disorder that can cause hyperthyroidism, or overactive thyroid.

Late Phase occurs _____ hours after exposure

Antigen-Antibody complex precipitate out and deposit in the ___?

Most severe hypersensitivity

Inherited tendency to respond to naturally occurring inhaled and ingested allergens with continued production of IgE

A type of graft within the same individual

A type of graft that is genetically identical individual

A type of graft that is non-identical member of the same species

Member of different species

Preformed antibodies to ABO, HLA, and certain endothelial antigens bind to donor vascular endothelium, activating complement and clotting factors

Type of rejection occurs 3-5 days after transplant

Antibodies produced against HLA antigens bind to vessel walls, activate complement, and induce transmural necrosis and inflammation

Delayed type hypersensitivity response, and possibly antibodies, to foreign HLA antigens on graft

T cells in HSC, lung, or liver transplants react against foreign HLA proteins in the recipient's cells causing massive cytokine release, inflammation, and tissue destruction in various locations throughout the body.

Type of rejection occurs 100 days or more after transplant