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Test your knowledge of atypical manifestation of neurotoxicity following CAR T-cell therapy

Transverse myelitis can be an atypical manifestation of immune effector cell-associated neurotoxicity syndrome (ICANS).

True

False

Potential treatment for transverse myelitis related to ICANS includes which of the following?

Corticosteroids

Intravenous immunoglobulin

Plasma exchange

All of the above

Moderate to severe ICANS should be treated with which of the following medications?

Tocilizumab

Corticosteroids

Filgrastim

Acetaminophen

Diagnostic evaluation of symptoms related to ICANS should include which of the following?

CT and/or MRI of the brain

EEG

Lumbar puncture

All of the above

Which of the following is a risk factor for developing ICANS?

Female

Younger age

Number of lines of therapy prior to CAR T-cell therapy

History of intrathecal chemotherapy

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