Pharmacology Review P2

Two drugs that are found to be chemically equivalent, but not biologically or therapeutically equivalent are said to differ in
Chemical structure
Bioavailability
Chemical effect
Onset
Controlled substances in schedule ______ require a written prescription with the provider's signature and do not permit refills
I
II
III
IV
On a prescription, the directions to the patient are preceded by
Sig.
Disp.
Refill
#.
A drug is defined as a biologically active substance that can modify
Cellular function
The environment
The pH of tissue
Immune response
Which of the following statements is true concerning the mechanism of action of drugs?
Drugs produce the same action
Drugs block the action of an endogenous agent
Drugs either produce the same action as an endogenous agent or block the action of an endogenous agent
None of the above
Which of the following statements is true regarding drug potency and efficacy?
Drug potency and efficacy have a synergistic relationship, meaning that the whole is greater than the parts.
Drug potency and efficacy show a positive correlation.
Drug potency and efficacy show a negative correlation.
Drug potency and efficacy are unrelated.
Administering a drug of greater potency is better because drugs of greater potency do not require as high a dose.
Both parts of the statement are true.
Both parts of the statement are false.
He first part of the statement is true, the second part is false.
The first part of the statement is false, the second part is true.
Which of the following is not a subject of pharmacokinetics?
Physiologic action of drugs
Metabolism of drugs
Elimination of drugs
Absorption of drugs
Which of the following statements is true concerning the pharmacokinetics of opioid analgesics?
Absorption may occur through mucous membranes of the nose but is not possible through intact skin.
The opioids are bound to plasma proteins to varying degrees and distributed throughout the body.
Given orally, opioids have vastly different durations of action for analgesia, ranging from 1 to almost 12 hours.
Metabolized opioids are excreted in urine; however, the unchanged drug is not.
The following agents are useful in the treatment of oral herpes lesions except one
Diphenhydramine liquid
Acyclovir
Corticosteroids
Viscous lidocaine
Sodium carboxymethylcellulose
Acyclovir should not be used prophylactically to prevent minor outbreaks of herpes because excessive use may lead to resistant strains of herpes.
True
False
Topical acyclovir will prevent the recurrence of herpes labialis.
True
False
The mechanism of local anesthetics involves action on
A) myelinated nerve
B) potassium channels
C) sodium channels
D) calcium channels
E) Both B and C
F) None of the above
The addition of a vasoconstrictor to a local anesthetic helps with what?
A) reduces blood supply to the area
B) limits systemic absorption
C) reduces systemic toxicity
D) A and B only
E) A, B, and C
Which of the following agents are the most commonly prescribed type of antianxiety drugs?
A) Nonbenzodiazepine-nonbarbiturate sedative-hypnotivs
B) Benzodiazepines
C) Opioids
D) A and B only
E) All of the above
Benzodiazepines enhance of facilitate the action of the neurotransmitter
Y-aminobutyric acid (GABA)
Acetylcholine
Dopamine
Glutamate
Which of the following parenteral benzodiazepines seems to have the greatest likelihood to produces amnesia?
Diazepam (Valium)
Eszopiclone (Lunesta)
Midazolam (Versed)
Triazolam (Halcion)
_________ is an intravenously administered benzodiazepine that is used for conscious sedation in oral health care
Midazolam (Versed)
Phenobarbital (Luminal)
Carisoprodol (Soma)
Ramelteon (Rozerem)
_____ may be used to reverse some of the effects of a benzodiazepine
Phenobarbital (Luminal)
Flumazenil (Romazicon)
Ramelteon (Rozerem)
Carisoprodol (Soma)
Which of the following classes of antiarrhythmics is associated with gingival enlargment
Amiodaribe
Calcium channel blockers
Disopyramide
None of the above
Alveolar osteitis, or "dry socket," occurs in 2% to 3% of all tooth extractions, most commonly in the _____ region.
A.mandibular incisor
Mandibular molar
Maxillary incisor
Maxillary molar
Negative feedback involves the action of adrenocorticosteroids on the
A) adrenal cortex
B) pituitary gland
C) hypothalamus
D) both B and C
E) A and C
The inflammatory activity of the adrenocorticosteroids may cause them to mask the symptoms of an infection. Adrenocorticosteroids decrease a patient's ability to fight infection by suppression of migration of plasma cells.
Both statements are true
Both statements are false
The first statement is true; the second statement is false
The first statement is false; the second statement is true
Which of the following emergency drugs is used to manage hypoglycemia in a patient with diabetes?
Diphenhydramine
Nitroglycerin
Albuterol
Glucose
The most common cause of hypoglycemia is
Stress or anxiety.
Insufficient hydration with water.
.an excessive dose of insulin in a patient with diabetes.
Cardiac medication
Which is considered first-line therapy for a patient with type 2 diabetes?
Diet and exercise
Glucagon
Oral antidiabetic agents
Insulin
More people are diagnosed with type II diabetes in the United States than are diagnosed with type I diabetes.
True
False
Antineoplastic agents will have the greatest negative effect on which of the following tissues?
GI tract
Bone marrow
Hair follicles
All of the above
Patients with asthma should bring their fast-acting ________ inhaler to be used prophylactically or in the management of an acute asthmatic attack in the dental office.
Aminophylline
Corticosteroids
β2-Agonist
Epinephrine
Which of the following signs is the most common emergency in the dental office?
Acute airway obstruction
Syncope
Hypoglycemia
Diabetic coma
Which of the following is a method of preventing an emergency in the dental office?
Taking a complete patient history
Training of personnel
Posting the telephone numbers for the closest physician, emergency room, and ambulance service
Having a well-stocked and up-to-date emergency kit
Which of the following choices would be the correct sequence for administration of emergency drugs for anaphylactic shock: (1) albuterol, (2) parenteral epinephrine, (3) intravenous corticosteroids?
1, 2, 3
1, 3, 2
2, 1, 3
2, 3, 1
3, 1, 2
Which of the following statements is true of the use of nystatin in either a pregnant woman or a nursing infant?
.Nystatin may be used by either a pregnant woman or a nursing infant.
Nystatin may be used by a pregnant woman, but not by a nursing infant.
Nystatin may be used by a nursing infant, but not by a pregnant woman.
Nystatin is not to be used by either a pregnant woman or a nursing infant.
Abuse of _____ is the number one public health problem in the United States.
Opioids
Stimulants
Alcohol
Hallucinogens
Which of the following drugs may be used to reduce alcohol craving?
Tamoxifen
Methotrexate
Naltrexone
None of the above
Which is the mechanism of action of xylitol for its antibacterial and cariostatic effects?
B and C only
All of the above
Inability to be metabolized by S. Mutans as a nutrient source
Direct bactericidal effect on Streptococcus mutans
Inhibition of the ability of S. Mutans to adhere and multiply in plaque
Each of the following is true of the FDA Food Safety and Modernization Act of 2010 EXCEPT one. Which is the EXCEPTION?
It requires the manufacturer to prove that an herbal product is safe and effective.
It requires the FDA to issue New Dietary Ingredients guidance.
It expands the facility registration obligations.
It provides the FDA with mandatory recall authority for all foods.
The FDA has performed much of the research and advanced the knowledge about herbal products and supplements. The German Federal Health Agency established the German Commission E to review and analyze world literature on plant-based products.
The first statement is false, the second is true.
Both statements are false.
The first statement is true, the second is false.
Both statements are true.
Which herbal supplement products have been proven effective in protecting against plaque and gingivitis?
Essential oil mouth rinse
B and D only
Xylitol
Oil of cloves (eugenol)
Triclosan
Acemannan hydrogel (extract of aloe vera)
An increased risk of bleeding can occur when __________ is taken in conjunction with antiplatelet drugs or anticoagulants.
Garlic
B, C, and D
Ginkgo biloba
St. John’s wart
Feverfew
Ma huang
All of the above
Oil of cloves has been used in dentistry for many years as a topical analgesic for dental pain. Extensive clinical trials have confirmed its efficacy.
The first statement is false, the second is true.
Both statements are false.
The first statement is true, the second is false.
Both statements are true.
Many consumers consider herbal products to be nontoxic or side effect free because they are often called “natural” remedies. Most herbal products cause no adverse effects and drug interactions.
Both statements are true.
The first statement is true, the second is false.
The first statement is false, the second is true.
Both statements are false.
The following statements are true of alveolar osteitis except which one?
Cigarette smoking increases its likelihood.
Antibiotic prophylaxis is recommended.
Diabetes is a predisposing factor.
Alveolar osteitis is attributed to loss or necrosis of the blood clot at the extraction site.
Alveolar osteitis occurs in 2% to 3% of all extractions.
The treatment of recurrent aphthous stomatitis (RAS) may include any of the following except which one?
Topical lauryl sulfate
Amlexanox
Diphenhydramine
Corticosteroids
Most cases of osteonecrosis of the jaw (ONJ) are associated with
Bisphosphonate therapy.
Cancer therapy.
Infection.
Use of steroids.
Glossopyrosis is another term for
Bald tongue.
Geographic tongue.
Vincent infection.
Pericoronitis.
Burning tongue.
Pericoronitis most commonly applies to partially erupted
Premolars.
First molars.
Third molars.
Incisors.
Recurrent aphthous stomatitis (RAS), which is sometimes referred to as a canker sore, is a common oral lesion occurring in approximately _____% of the population.
10
30
40
20
Which of the following conditions involves a focal immune dysfunction in which a decreased ratio of T-helper to T-suppressor/cytotoxic cells can be seen?
Acute necrotizing ulcerative gingivitis (ANUG)
Recurrent aphthous stomatitis (RAS)
Angular cheilitis
Alveolar osteitis
Geographic tongue
Acyclovir should not be used prophylactically to prevent minor outbreaks of herpes because excessive use may lead to resistant strains of herpes.
True
False
Which is the most potent topical corticosteroid?
Fluocinonide (Lidex)
Triamcinolone acetonide (TAC)
Hydrocortisone
Clobetasol (Temovate)
Which of the following agents is added to mouth rinses to function as a foaming agent that helps remove debris?
Surfactants
Benzoic acid
Glycerin
Alcohol
Experts recommend that fluoride applications remain in place for
4 minutes
1 minute
2 minutes
30 seconds
For dentinal hyperalgesia (DH) to develop, the dentin must become exposed through the loss of gingival recession or enamel, and
A carious exposure of the tooth pulp must be present.
The tooth must be in hyperocclusion.
The dentin tubules must be open to the oral cavity and the pulp.
Erosion at the cervical must be present.
Almost which percentage of Americans 60 years and older have lost all their teeth?
25
5
20
10
15
Proteins in dairy products raise pH levels and can inhibit bacterial growth.
True
False
The majority of desensitizing toothpastes contain
Oxalates
5% potassium nitrate
NaF
Adhesives and resins
Which of the following professionally applied preparations for in-office application has the highest fluoride concentration (ppm)?
0.4% SnF and 1.1% NaF in APF
Sodium varnish 5%
APF 1.23%
Sodium 2%
Approximately 40% of the general population has experienced dental caries.
True
False
Which is a bisbiguanide local antiinfective available in a 0.2% mouthrinse?
Chlorhexidine gluconate
Xylitol
Essential oil
Triclosan
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