Test your knowledge of CAR T-cell therapy

Which CAR T-cell therapy is approved for the treatment of relapsed or refractory multiple myeloma?
Tisagenlecleucel
Axicabtagene ciloleucel
Ciltacabtagene autoleucel
Brexucabtagene autoleucel
What is the first FDA-approved CAR T-cell therapy for B-cell acute lymphoblastic leukemia (ALL)?
Tisagenlecleucel
Axicabtagene ciloleucel
Brexucabtagene autoleucel
Idecabtagene vicleucel
What is a common side effect of CAR T-cell therapy that involves high fever and flu-like symptoms?
Tumor lysis syndrome
Cytokine release syndrome (CRS)
Immune reconstitution inflammatory syndrome
Graft-vs-host disease
Which complication involves symptoms such as headaches, confusion, seizures, and aphasia?
Cytokine release syndrome
Immune reconstitution inflammatory syndrome
Immune effector cell-associated neurotoxicity syndrome (ICANS)
Tumor lysis syndrome
What is the role of lymphodepleting chemotherapy before CAR T-cell infusion?
To enhance CAR T-cell expansion and persistence
To directly kill cancer cells  
To reduce side effects of CAR T-cell therapy  
To boost the patient's immune system
Which marker is most commonly targeted by CAR T-cell therapies in B-cell malignancies?
CD19
CD20
CD22
CD30
For which disease is CAR T-cell therapy most effective?
Aplastic anemia
Non-Hodgkin lymphoma
Pancreatic cancer  
Colon cancer
How is the novel "armored" CAR T-cell therapy called huCART19-IL18 designed to enhance effectiveness in patients with non-Hodgkin lymphoma who have not responded to standard CAR T-cell therapy?
It targets skin cancer by using genetically modified T-cells to produce interleukin 2 (IL-2)
It targets CD19 and is modified to secrete interleukin 18 (IL-18), enhancing its anti-tumor activity and reducing the manufacturing time to 3 days
It inhibits the growth of non-Hodgkin lymphoma cells by blocking the CD20 protein on their surface
It boosts the immune system's response to non-Hodgkin lymphoma by introducing a modified version of the Epstein-Barr virus
What is a major barrier to the widespread use of CAR T-cell therapy?
Lack of effectiveness in treating cancer 
High cost and complex manufacturing process
Limited approval for many cancer types
Absence of any significant side effects
Which of the following is an emerging strategy to enhance the efficacy of CAR T-cell therapy?
Combining CAR-T cells with checkpoint inhibitors
Using CAR-T cells in conjunction with radiation therapy
Enhancing CAR T-cell survival with cytokine support  
All of the above
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