IP1.T1.Q1

Neurons in which of the following systems have adrenergic fibers? Select all that apply
PNS
SNS
Enteric
Somatic
Which of the following neurotransmitters is normally released into the SA node when sympathetic post ganglionic fibers are stimulated?
Dopamine
Norepinephrine
Epinephrine
Glutamate
Ach
A patient has Horner’s syndrome. There is an interruption of preganglionic to postganglionic fibers in the sympathetic innervation on to his face. What neurotransmitter is primarily involved in this disease?
Norepinephrine
Dopamine
Epinephrine
Acetylcholine
All postganglionic fibers in the PNS release acetylcholine?
True
False
All preganglionic fibers in the SNS release neurotransmitters that act on muscarinic receptors?
True
False
Somatic neurons release acetylcholine acting on skeletal muscle muscarinic receptors to induce muscle contraction.
True
False
What amino acid is involved in the synthesis of acetylcholine at box #4?
Tyrosine
Choline
Threonine
Serine
What enzyme is involved in the degradation of acetylcholine at box #8?
Acetylcholinesterase
Tyrosine Hydroxylase
Choline Acetyltransferase
What intracellular enzyme is involved in the degradation of acetylcholine?
MAO
COMT
Tyrosine Hydroxlase
None
Stimulating Beta-3 receptors in the detrusor muscle would result in?
Contraction of the sphincter
Bronchodilation
Decreased secretions
Relaxation of the muscle
Stimulating Beta 1 receptors on the kidney would result in increases in blood pressure.
True
False
Stimulating ________ receptors in the iris circular muscle would result in ______.
M3 – miosis
M3 – mydriasis
Alpha 1 – miosis
Beta 1 – mydriasis
Stimulation of which of the following receptors would be used to initiate a decrease in BP? Select all that apply.
Beta 1 in Kidney
Alpha 2 in Arteries
Beta 1 in heart
Alpha 2 in Pancreas
Determine which of the following drugs when administered IV would cause parasympathetic vagal efferent activity to increase due to the baroreflex.
Epinephrine
Norepinephire
Acetylcholine
Clonidine
Phenylephrine’s direct effect on the heart rate is?
Increases
Decreases
Stays the Same
Phenylephrine’s overall effect on heart rate is?
Increases
Decreases
Stays the same
What direct effect does methyldopa administration have on adrenergic receptors in the kidney influencing blood pressure?
Increasing Blood Pressure
Decreasing Blood Pressure
No Effect
Which agent is correctly matched with an appropriate pharmacologic effect?
Methyldopa – direct binding to Alpha 1 receptors
Clonidine – CNS sympatholytic action
Phenylephrine – rapid acting arterial vasodilation
Which compound would you expect to be a better bronchodilator? ? What functional groups support your answer?
A - Hydroxyl
A - t-butyl
B - Hydroxyl
B - t-butyl
A - methanol
B - methanol
Which of the following statements concerning the organization of the autonomic nervous system is accurate?
Cholinergic preganglionic fibers in the sympathetic nervous system stimulate nicotinic receptors in the ganglion
Adrenergic preganglionic fibers in the sympathetic nervous system stimulate alpha-1 receptors in the ganglion
Cholinergic postganglionic fibers in the sympathetic nervous system stimulate beta-1 receptors on the heart to increase heart rate
Adrenergic fiber stimulation innervating the adrenal medulla initiate the release of epinephrine and norepinephrine
Inhibiting ______ will increase norepinephrine levels in the synaptic clefts. Select all that apply.
Tyrosine hydroxylase
Norepinephrine reuptake transporter
Presynaptic alpha-2 receptors
Dopamine beta hydroxylase
Which of the following is accurate regarding somatic motor neurons?
The neurotransmitter at the somatic motor neuron ganglion is norepinephrine
Somatic motor neurons innervate smooth muscles
Somatic motor neurons do not have ganglia
The neurotransmitter at the somatic motor neuron ganglion is acetylcholine
Your 30 y/o patient has moderately severe new onset of asthma, and he is prescribed a highly selective beta-2 agonist inhaler to be used when needed. In considering the possible drug effects in this patient, you would note that beta-2 stimulants have the possibility to cause which of the following?
Tachycardia
Miosis
Trigone muscle contraction
Direct stimulation of renin release
Which of the following statements about the active form of methyldopa is true?
Increases sympathetic tone
Exerts agonist activity on alpha-1 receptors
Exerts agonist activity on alpha-2 receptors
Exerts agonist activity on beta-1 receptors
Decreases parasympathetic tone
Epinephrine is injected into a thigh muscle. What happens to the pupil?
Miosis
Mydriasis
No Effect
Iris changes color
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