What is the indication for administering Radium-223?
Treat prostate cancer bone metastases in men with castration resistant prostate cancer
Allow imaging of prostate cancer metastases
As a combination therapy with chemo- and radiation therapies
Treat all metastases in patients with prostate cancer
What is the primary emission of Radium-223 (Xofigo)?
Alpha emission
Beta emission
Gamma emission
X-rays
How is Xofigo (Radium-223) localised in the bones?
Taken up by hydroxyapatite crystals and incorporated into the bone matrix
Passive diffusion
Xofigo doesn't localise in bone
Depends on blood flow to surrounding tissue
What are the possible side effects of Xofigo (Radium-223)?
GIT upset including diarrhea, nausea and vomiting
Decreased platelets, RBCs and WBCs
Oedema, particularly in arm of injection site
All of the above
Which organs are known to have Radium-223 (Xofigo) uptake when injected intravenously?
Bones
Heart
Liver
Spleen
Kidneys
Bladder
All of the above
What is the range for alpha particles when Xofigo is injected intravenously and absorbed into sites of bone metastases?
10 cells diameter
10 cm
100 micrometers
100 cm
Which collimator would we use for imaging Xofigo distribution?
Low energy (140keV)
Medium energy (269keV)
High energy (360keV)
What is the dosage of Xofigo administered?
50kBq/kg (~3-4MBq)
5MBq/kg (300-400MBq)
50kBq
200MBq
What percentage of Xofigo is present in the bloodstream 24 hours post-injection?
20%
4%
2%
<1%
What is the main method of excretion?
Urinary
Faecal
No excretion
What types of radiation are emitted by Radium-223 and its daughters?
Alpha particles
Beta particles
Gamma rays
All of the above
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