Radium-223

What is the half life of Radium-223?

11.4 days

1601 years

11.4 hours

1601 seconds

What is the indication for administering Radium-223?

Treat prostate cancer bone metastases in men with castration resistant prostate cancer

Allow imaging of prostate cancer metastases

As a combination therapy with chemo- and radiation therapies

Treat all metastases in patients with prostate cancer

What is the primary emission of Radium-223 (Xofigo)?

Alpha emission

Beta emission

Gamma emission

X-rays

How is Xofigo (Radium-223) localised in the bones?

Taken up by hydroxyapatite crystals and incorporated into the bone matrix

Passive diffusion

Xofigo doesn't localise in bone

Depends on blood flow to surrounding tissue

What are the possible side effects of Xofigo (Radium-223)?

GIT upset including diarrhea, nausea and vomiting

Decreased platelets, RBCs and WBCs

Oedema, particularly in arm of injection site

All of the above

What is the range for alpha particles when Xofigo is injected intravenously and absorbed into sites of bone metastases?

10 cells diameter

10 cm

100 micrometers

100 cm

Which collimator would we use for imaging Xofigo distribution?

Low energy (140keV)

Medium energy (269keV)

High energy (360keV)

What is the dosage of Xofigo administered?

50kBq/kg (~3-4MBq)

5MBq/kg (300-400MBq)

50kBq

200MBq

What percentage of Xofigo is present in the bloodstream 24 hours post-injection?

20%

<1%

What is the main method of excretion?

Urinary

Faecal

No excretion

What types of radiation are emitted by Radium-223 and its daughters?

Alpha particles

Beta particles

Gamma rays

All of the above

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