Formative Quiz
A positive Babinski response (upgoing response of big toe to scratch the plantar surface of the foot in an adult) ALWAYS indicates or involves:
Upper motor neuron dysfunction
Elevated amounts of acetylcholine released at neuromuscular junctions
Relaxation of the extensor hallucis longus muscle
Allodynia
Brain infarct
A common consequence of Parkinson's disease, acute coronary syndrome and post-traumatic stress disorder is:
Tolerance to medication
Depression
Heart failure
Autonomic insufficiency
Flashbacks
An unconscious man is brought into emergency. His eyes open in response to pain and he exhibits a flexion posture in his arms in response to pain, but he does not respond to verbal stimuli. The patient's Glasgow Coma Scale score is:
11-13
0-1
5-7
8-10
2-4
When examining a patient admitted with sudden onset right-sided weakness which of the following is the best indicator of a stroke of the brainstem?
Inability to abduct the left eye
Deviation of the tongue to the right
Right gaze preference
Right homonymous hemianopia
Right lower facial weakness
Which of the following is LEAST CONSISTENT with a diagnosis of schizophrenia?
Psychosis directly linked to drug use
Visual hallucinations
Disorganised or catatonic behaviour
Delusions
Disorganised speech
All of the following are consistent with a diagnosis of post-traumatic stress disorder, EXCEPT
Self-medication
Hypervigilance
Avoidance behaviour
Euphoria
Irritability
Which of the following BEST exemplifies tertiary prevention of drug-related harm?
Alcohol-free youth events
School based education on drags
Administering AUDIT-C questionnaire
Referral to withdrawal intervention
Pre pregnancy advice on drugs
The 30 year old taxi driver presents with four weeks of low mood, anhedonia poor sleep and mood congruent 2nd person auditory hallucinations. He stop driving his cap which is the MOST LIKELY diagnosis?
Schizoaffective disorder
Serve depression
Mild depression
Schizophrenia
Moderate depression
A 22 year old woman presents with a 12 month history of gradually deteriorating function, which she attributes to ongoing voices inside ahead talking about her. She believes the voices represent an organisation that rules the world. Over the past two weeks she has become very depressed. What diagnoses best explains her symptoms?
Schizoaffective disorder
Schizophrenia
Bipolar affective disorder type I
Schizotypal personality disorder
Bipolar affective disorder type III
A post surgical patient on the hospital, who seems to have cognitive impairment and answers "I don't know" to almost all questions asked of her as part of a mental state exam MOST LIKELY has
Delirium or dementia
Dementia or depression (pseudodementia)
Dementia only
Depression (pseudodementia) only
Mike, a 60 year old man, is brought from work to the emergency department (ED) by ambulance. His coworkers told the ambulance crew that he rose quickly from his chair at the end of a long meeting, took a couple steps, seemed to go rigid and then fell backward. The ambulance crew was caught immediately and by the time they arrive 15 minutes later found the man lying on the couch in the tea room. Semi conscious and very confused. On presentation in Ed about 30 minutes after his for, Mike is lucid and knows where he is, but still somewhat confused. His vital signs are: Heart rate 97. Respiration Rate 14/min Blood pressure 90 / 60 (supine) Temperature 38.5 degrees. When asked, “Do you know why you are here”, he answers “I do not remember much. I was at work and I was standing I blacked out: at least I think I blacked out.” The examining physician hypothesises that Mike has had an epileptic seizure. The MOST LIKELY classification of the seizure described in Mike's presentation is:
Atonic
Absence
Complex partial
Tonic clonic
Simple partial
All the following conditions can lead to psychotic symptoms EXCEPT:
Motor neurone disease
Temporal lobe epilepsy
Charles bonnet syndrome
Lewy-body disease
Delirium
Which of the following statement in INCORRECT?
Clozapine can reduce suicide
Fluoxetine is a licensed antidepressant
Antipsychotic medications can cause diabetes
Antidepressants are addictive
Naltrexone is used to manage addictions
The treatment of choice for bipolar depression is:
Electroconvulsive therapy
Mood stabiliser medication
Psychotherapy
Antidepressant medication
St john wort
A 45 year old man presents with a severe headache. On examination, he has a stiff neck and is drowsy. His left eyelid is droopy and covers the left pupil. His left eye has deviated laterally and slightly downwards. It does not move on attempted upward and right gaze. The right eye moves normally.
What structure has been damaged to produce these ocular findings?
Cranial nerve III
Ciliary ganglion
Cranial nerve IV
Superior colliculus
Cranial nerve VI
Which of the following neuroimaging investigations will have the greatest diagnostic yield in terms of differentiating Alzheimer's dementia from Lewy Body Dementia?
PET Scan
MRI
DAT Scan
CT Scan
SPECT SCAN
PICKLE Scan
A combination of unilateral weakness in the lower facial muscles and the upper and lower limbs is consistent with a lesion in which of the following structures?
The occipital lobes
The ipsilateral inferior pons
The area of the contralateral cerebral cortex perfused by the middle cerebral artery
The ipsilateral lateral medulla
The area of the contralateral internal capsule perfused by the middle cerebral artery
A 27-year-old woman presents with an acute headache. She has a three-month history of intermittent headaches but says that this one has lasted for 24 hours, and so she is worried about it. She says that here headaches seem to occur before the start of her menstrual period, are usually on the left side of her head, and she describes them as severe and throbbing. The headaches preceded by a partial loss of her right visual field about 15-20 minutes before the headache starts. She has a past history of oral contraceptive (OCP) use from the age of 15 until 25. On examination, she looks pale and washed out, has normal vital signs and no focal neurological signs. What is the most likely diagnosis?
Tensions headaches
Subarachnoid haemorrhage
Transient ischemic attacks (TIA)
Brain tumour
Migraine headaches
A 6-year old boy is admitted to the emergency department with a prolonged seizure. A medication of the benzodiazepine class is administered intravenously in an attempt to stop the seizure activity. Benzodiazepines act by:
Acting as a serotonin agonist
Blocking the metabolism of dopamine
Increasing the likelihood of an action potential in their target cells
Increasing chloride influx into the neuron
Blocking the GABA (gamma-aminobutyric acid) receptor
A patient with oculomotor nerve palsy is LIKELY to show:
Partial ptosis, miosis and infero-lateral deviation of the eye
Complete ptosis, mydriasis and infero-lateral deviation of the eye
Complete ptosis, mydriasis and infero-medial deviation of the eye
Complete ptosis, miosis and medial deviation of the eye
Partial ptosis, mydriasis and lateral deviation of the eye
Diazepam modulate GABA-A receptor by which of the following mechanism?
Increasing the synthesis of GABA
Increasing the frequency of opening of GABA-B receptor
Increasing the frequency of opening of GABA-A receptor
Increasing the duration of opening of GABA-A receptor
Increasing the frequency of release of GABA
A 45 year old male presents with a 'change in personality' as reported by his wife and recent episode of a tonic-clonic seizure. CT scan revealed a frontal mass and the histopathological examination revealed multiple calcifications and cells with a 'fried egg' appearance. What is the LIKELY diagnosis?
Astrocytoma
Meningioma
Arteriovenous malformation
Glioblastoma
Oligodendrocytoma
The reason dopamine is NOT used as a drug to treat Parkinson's disease is because dopamine:
Causes desensitisation of dopamine receptors in the brain
Does not cross the blood-brain barrier
Inhibits the conversion of dihydroxyphenylalanine (dopa) into dopamine as a consequence of feedback inhibation
Has too short a half-life to be clinically useful as a drug
Undergoes extensive first pass metabolism in the liver to be therapeutically effective
A 40-year old previously well man presents to his general practitioner at the request of his wife. He describes poor sleep for the past six weeks associated with a low mood, feelings of worthlessness and a lack of interest in hobbies. He has been experiencing some auditory hallucinations for the past two weeks and has just lost his job as a school cleaner. Which of the following disorders is the MOST LIKELY reason for his symptoms.
Drug induced psychosis
Alcoholism
Borderline personality disorder
Major depression
Schizophrenia
Albert is a 65 year old hypertensive patient who has presented acutely with difficulty in communication most likely due to a thromboembolic stroke. On examination, it is noted that his speech is fluent, but he does not make any sense and he is unable to carry out simple instructions as he appears not to understand either spoken or written words. This patient is MOST LIKELY to have a lesion in (the):
Primary auditory area
Broca's area
Wernicke's area
Supplementary motor area
Arcuate fasciculus
A 61 year old male died of Alzheimer's disease. Which of the following tissue changes is diagnostic of this disease during post-mortem?
Microcystic degeneration
Gliosis
Lymphovascular cufffing
Amyloid plaque deposition
Demyelination
A 14 year old female was rushed to the emergency department with severe headache, fever and vomiting. Diagnosis of meningitis was made after noting inflammatory cells in the cerebral spinal fluid following a lumbar puncture. Which of the following structure is MOST LIKELY to be damaged by the pathogen in this patient?
Oligodendrocytic end-feet
Tight junctions between the pericytes
Blood-brain barrier
Tunica intima of the cerebral arteries
Connective tissues of the neuropil
The MRI scan from a 28 year old man revealed multiple white matter hyperintensities suggestive of brain scars. The cell type which plays a significant role in the formation of this radiological finding is
Microglial cells
Neuropils
Ependymal cells
Oligodendrocytes
Astrocytes
Ondansetron produces its anti-emetic effect by blocking which of the following receptors?
Dopamine D2 receptors
The chemoreceptor trigger zone (CTZ)
5-HT3 receptors
Muscarinic M1 receptors
Histamine H1 receptors
Which of the following anxiolytic drug acts on serotonergic receptors and does not produce significant sedation like benzodiazepines?
Alprazolam
Buspirone
Sumatriptan
Ondansetron
Diazepam
The major serotonin containing nuclei in the brain are located in:
Prefrontal cortex
Raphe nuclei
Locus coeruleus
Substantia nigra
Nucleus basalis
Which of the following features is MOST associated with DEPENDENCE on a substance?
Withdrawal symptoms
Decreased potency with repeated administration
Reduced risk of addiction in adolescents
Craving and excessive thinking about the substance
Daily use of the substance
A recognised chronic effect of typical antipsychotic medications is:
Decreased prolactin secretion
Dystonia
Increased alertness
Anti depressant activity
Increased activity in the substantia nigra
A 22 year old man has been brought to the emergency department, accompanied by a police officer has sustained a hand injury during an aggressive outburst after taking methyl ampheramine. Witness said that became very active and agitated after taking the drug and seemed to be experiencing hallucinations. The admitting intern thinks that the man has an acute amphetamine-induced psychosis. Amphetamine psychosis results in disturbed behavior patterns by which one of the following mechanisms?
Increased production of norepinephrine
Stimulation of cells in the substantia nigra
Increased brain dopamine activity
Activation of the peripheral sympathetic nervous system
Increased cAMP activity in cells of the nucleus accumbens
A patient who presents with amnesia is MOST LIKELY to have diminished function in the
Hippocampus
Medulla oblongata
Amygdala
Frontal poles of the temporal lobe
Cerebellum
A yo year old man is brought to the HP by his concerned wife who reports that he frequently gets lost when he drives to the local shops and makes offensive remarks to strangers in the shopping centre. During the consultation, he appears to be cheerful man who explains that he was just being happy and jovial with people. When questioned about his tendency to get lost he says that it only happens when he is not concentrating on where he is going, and it is not an issue if he pays attention. He says "there is nothing wrong with me"
What is the MOST LIKELY diagnosis?
Normal ageing
Delirium
Alzheimer's dementia
Major depressive disorder
Amnesia
What is the initial treatment of choice for mild to moderate depression?
Lithium
Psychodynamic psychotherapy
Selective serotonin reuptake inhibitors
Cognitive behaviour therapy
Serotonin and norepinephrine reuptake inhibitors (SNRIs)
A 58 year old man presents with sudden onset of loss of speech and right sided weakness. His examination showed global aphasia, right facial weakness, right hemiparesis (arm > leg) and right homonymous hemianopia
Which blood vessel is most likely to have been occluded?
Posterior communicating artery
Posterior cerebral artery
Anterior cerebral artery
Middle cerebral artery
Lenticulostriate artery
Carbidopa and levodopa (L-dopa) are used in conjunction in treating Parkinson's disease.
What is the primary effect of the carbidopa?
Increases the transport of L-dopa across the blood-brain barrier
Reduces the metabolism of L-dopa to inactive metabolites
Increases conversion of L-dopa to dopamine in the CNS
Increases metabolism of dopamine to its active metabolite
Reduces the conversion of L-dopa to dopamine in the periphery
In a patient with suspected depression, which of the following actions would MOST LIKELY support an alternate diagnosis of bipolar disorder?
Increasing time spent away from work and at home
Increasing interest in risky sports
Increasing alcohol consumption
Increasing body weight
Increasing sleep time
A combination of sensory loss of taste on the anterior tongue and facial paralysis are consistent with a lesion in which of the following structures?
The ipsilateral inferior pons
An area of the brain perfused by the middle cerebral artery on one side
Broca's area: non-dominant hemisphere
The occipital lobes
The ipsilateral lateral medulla
In addition to having experienced a traumatic event in the past, which of the following symptoms would differentiate post-traumatic stress disorder from other anxiety disorders?
Excessive worry
Hypervigilance is not related to any specific phobia
Recognition that his/her fears are excessive
Excessive physiological response, such as tachycardia, to normal life events
Substance abuse
What is the cardinal feature of delirium?
Day night reversal
Sleepiness
Hallucinations
Agitation
Distractibility
Which of the following is an example of a non-glial cell tumour in the brain?
Oligodendroglioma
Anaplastic ependymoma
Glioblastoma
Astrocytoma
Meningioma
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