Pharma Anti Microbial

A pa#ent allergic to penicillin is being evaluated for a gram-nega#ve infec#on. Which an#microbial drug class would the health care provider be cau#ous in prescribing because of a possible cross sensi#vity and/or allergic reac#on?
Aminoglycosides
Quinolones
Cephalosporins
Sulfonamides
The health care provider has prescribed penicillin and probenecid for a pa#ent with a sexually transmi"ed disease. What is the purpose of combining these medica#ons?
To reduce toxic effects associated with penicillin
To inhibit the excre#on of the penicillin
To inhibit the absorp#on of penicillin to allow the drug to remain in the transport phase
To accelerate the excre#on of the penicillin
An older adult who has sep#cemia is receiving IV aminoglycoside therapy. Which symptom is most important for the nurse to monitor?
Bone marrow suppression
Gastrointes#nal (GI) distress
Ototoxicity
Photosensi#vity
On what is the selec#on of an an#microbial agent based?
Bioavailability of the drug
Sensi#vity of the microorganism to the drug
Therapeu#c levels of the drug
Half – life of the medica#on
A pa#ent is scheduled to take tetracycline and aluminum hydroxide (Amphojel) at the same #me. When will the nurse administer the medica#ons to achieve the op#mal effects?
Tetracycline 1 hour before Amphojel
Amphojel 30 minutes before tetracycline
Tetracycline with orange juice
Both medica#ons together
Penicillin was considered a "miracle drug" for all of the following reasons EXCEPT A) it was the first an#bio#c. B) it does not affect eukaryo#c cells. C) it inhibits gram-posi#ve cell wall synthesis. D) it has selec#ve toxicity.
C
D
A
B
Which of the following methods of ac#on would be bacteriosta#c?
inhibi#on of cell wall synthesis
compe##ve inhibi#on with folic acid synthesis
injury to the plasma membrane
inhibi#on of protein synthesis
Which of the following an#bio#cs does NOT interfere with cell wall synthesis?
Cephalosporins
natural penicillin
semi synthe#c penicillin
Macrolides
In the presence of penicillin, a cell dies because
D. it lacks a cell membrane.
A. it lacks a cell wall.
B. it plasmolyzes.
C. it undergoes lysis.
A bacteria may produce an enzyme iden#fied as BETA-LACTAMASE, which can break open the betalactam ring resul#ng to inac#va#on of beta lactams, hence, ineffec#ve. An example of a Beta-lactamase inhibitor penicillin is;
Amoxicillin
Clavulanic acid
Nafciliin
Penicillin
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