P067 Assay Quiz Part 1
P067 Assay Quiz Part 1
Test your knowledge on the P067 assay and its various components!
This quiz covers crucial aspects of MDR1-MDCK and Caco-2 assays, including controls, inhibitors, and techniques used in the field.
- 10 questions to assess your understanding
- Multiple-choice and checkbox formats
- Engage with topics relevant to pharmacokinetics
Which of the following controls are used in a standard MDR1-MDCK assay?
Talinolol & Prazosin
Antipyrine & Prazosin
Antipyrine & Propranolol
Atenolol & Talinolol
Which of the following controls are used in a standard Caco-2 assay?
Atropine, E3S, Atenolol & Antipyrine
Prazosin, Propranolol, Atenolol & E3S
Digoxin, Atenolol, Talinolol & Antipyrine
Antipyrine, Atenolol, Talinolol & E3S
Which of the below is a P-gp inhibitor used in our assays?
Elacridar
FTC
Novobiocin
MK-571
Which of the below is a BCRP inhibitor used in our assays?
Digoxin
FTC
Verpamil
Atenolol
Why might we get high or low C0s in our data?
Poor solubility
Poor mixing
Too much/little buffer added
All of the above
Why is it important to calculate recovery of test compound in our assays? Select all that apply.
To determine whether there has been any non-specific binding
For calculating the Papp
To determine if there are potential solubility issues
To ensure the compound has not been retained within the cells
To see if the compound has been metabolised intra-cellularly
To ensure the cells have formed a confluent monolayer
Finish the sentence. Lucifer yellow is used in P067 assays in order to...
Mark which solution is our donor dosing solution
Confirm efflux transporters are functioning correctly
Ensure the cells have formed confluent monolayers
Increase the solubility of test compounds
Prazosin is a...
BCRP substrate
P-gp inhibitor
P-gp substrate
MRP2 substrate
Antipyrine is our...
High permeability control (97%)
High permeability control (90%)
Mid permeability control (50%)
Low permeability control (20%)
E3S is a...
High permeability control
MRP2 substrate
BCRP substrate
P-gp inhibitor
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