ARVC Quiz based on the 2023 ESC Guidelines for Cardiomyopathies

What statement is the most fitting regarding the clinical presentation of ARVC?
A. Women are generally more affected
B. RV regional wall motion abnormalities (bulgings, aneurysms) are in keeping with athletic adaptation
C. T wave inversion in leads V1-V3 and low QRS voltage in the peripheral leads are potential ECG features
D. Is a disorder with a constantly high penetrance
ARVC is a genetically determined cardiomyopathy. Which option is true about the genes involved in ARVC?
A. TMEM43 and PLN are desmosomal genes
B. Carriers of DSP or DSG2 are more prone to develop heart failure
C. The diagnostic yield of the genetic testing is around 10 %
D. The pattern of inheritance is mostly autosomal recessive, lowering the chances of finding the condition in 1st degree relatives
Which of the following is true about the antiarrhythmic therapy options in ARVC?
A. Titration of beta-blockers to maximal tolerated dose does not have a clear benefit on survival from major ventricular arrhythmias
B. Ventricular tachycardia ablation can be performed
C. Flecainide should not be used
D. Sympathetic denervation may be useful in reducing ventricular tachycardia burden, and is sufficient to protect against sudden cardiac death
A 20-year-old male with palpitations undergoes transthoracic echocardiography. The right ventricle is enlarged; however, the longitudinal and global function appear normal. The left ventricle has normal size and normal systolic function. What would you assess next?
A. Right ventricular free wall strain
B. Qp/Qs
C. Cardiac MR
D. Genetic testing
Which statement is not true about the primary prevention of sudden cardiac death in ARVC?
A. RVEF < 40% is a high-risk feature
B. Sustained ventricular tachycardia, even in the absence of syncope, is an indication for ICD
C. There is no dedicated risk score calculator for patients with ARVC
D. LVEF < 45% is a high-risk feature
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