CND Quiz

Amlodipine can be given once daily because it has a half-life of _______ hours

20 hours

25 hours

≥35 hours

12 hours

The anti-hypertensive effect of amlodipine is manifested as __________________

vasoconstriction especially in children

vasodilation in peripheral vascular beds

increased incidence of lipid abnormalities

headaches

Valsartan is indicated for the treatment of _______.

The maximum possible dose of Valsartan that can be given in a single day is ______ mg

40 mg

80 mg

160 mg

320 mg

Select the most common side effect of amlodipine from below:

Loss of appetite

Pedal Edema

Headache

Nausea

Adding Valsartan to HCTZ offers the following the benefit, except for:

Additive blood pressure reductions without major effects on heart rate

Adding HCTZ 12.5 or 25 mg/day to valsartan 80 mg/day resulted in a greater blood pressure reduction than increasing the valsartan dosage from 80 to 160 mg/day

Valsartan/HCTZ combination was generally more effective than either drug given alone

Valsartan/HCTZ combination has no side effects

Valsartan + Hydrochlorothiazide fixed dose combination can be prescribed to a patient newly diagnosed with hypertension:

True

False

Which of the following is not an attribute of valsartan?

Sustained reduction in blood pressure

Can be used in patients with history of MI

Cannot be used in patients with newly diagnosed hypertension

Co-administration with diuretics provides improved control of hypertension

Efficacy, tolerability and safety of valsartan have been demonstrated in large-scale studies for:

Hypertension

Heart failure (HF)

Post-myocardial infarction (MI)

all of the above

Despite a shorter half-life, 160 mg/day Valsartan was more effective in lowering blood pressure over 24 h than 80 mg/day telmisartan.

True

False

In heart failure, Valsartan is given in an initial dose of 40mg twice daily. The dose should be increased, as tolerated, to 160mg twice daily

True

False