Medo 2 - Pharmacy Committee
The drug illustrated below : 1- Is an osmotic diuretic. 2- Is freely reabsorbed into blood stream. 3-Is selectively leads to water excretion without affecting electrolyte reabsorption. 4-Is freely filtrated through the Bowman's capsule into the renal tubule.
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1 and 3
1 and 4
all except 3
2
Based on the SAR of carbonic anhydrase inhibitors , which of the following structural modifications is (are) mismatched with its logical explanation :
The aromatic moiety is better to be thiadiazole : to enhance the acidity of the sulfonamide
Electron withdrawal substituents at the phenyl ring :enhances drug's activity
The R1 can be oxazole :to enhance the acidity of the sulfonamide
The sulfonamide should be primary : substituents other than hydrogen decrease or abolishe activity
Replacing the sulfone moiety with a carbonyl:decrease or abolishes the acidity of the drug
Which is the following compounds best fulfills the following description :a compound that blocks the action of carbonic anhydrase and is used to treat glaucoma by reducing intraocular pressure :
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Which of the following compounds is an inhibitor of the Na+\Cl- symporter and inhibits the reabsorption od sodium and chloride ions ?
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Which of the following compounds is the MOST ACTIVE as a thiazide diuretic?
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Which is the following structural modifications are associated with enhanced potency and\or duration of action of the following thiazide drug?
A-Replacment of the chloro at position 6 with triflouromethyl
B-Reduction of the C3-C4 double bond
C-Hydrophilic substituent at C3
D- All of the above
E- A and C
All of the following sentences regarding the shown drug are wrong , EXCEPT:
It is a thiazide diuretic
Competes with chloride ion at the Na+\Cl- symporter and inhibits the reabsorption od sodium and chloride ions
Is a phthalamide derivative
Is ineffective as a diuretic and is mainly used for treatment glaucoma
All are wrong
Examine the following two drugs and select the INCORRECT sentence from those that follow . *A is the first drug from the left, B on the right.
Both drugs are K-depleting diuretics
Drug A is a thiazide analogue
Both drugs are potent diuretics
Drug B is more potent diuretic than A
The carboxylic moiety of the drug A can be isosterically replaced with a tetrazole without loss of activity
Which of the following sentences is ( are) CORRECT regarding drugs A and B ?
A. They are indirect K-sparing diuretics of a steroid scaffold
B. Both have same binding affinity to their target receptor
C. Hydrolysis of the thioester of A results in in active metabolites
D. A and C
E. Drug B is associated with higher incidence of sexual side effects
The most active carbonic anhydrase inhibitor is :
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The most active HMG-CoA reductase inhibitor is
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Which of the following structural characteristics are CURRENTLY explained or described?
The two drugs are spiro compounds which refers to the alpha-beta unsaturated ketone functionality
The cyclic ester is reffered to as lactam
Substitutes at position 7 are crucial for antagonistic activity
The oxygen-containing ring in drug B is called oxide
None of them
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