Pharm test 3
In treating a hyperthyroid patient which agent inhibits the peripheral conversion of T4 (thyroxine) to T3 (Triiodothyronine)
Carbamazepine (tegretol)
Atenolol
Propylthiouracil
Methimazole
Which of the following agents has the greatest risk for producing post-treatment hypothyroidism?
Anteolol (Tenormin)
Methimazole )tapizole)
Propylthiouacil
Radioactive iodine
Which drug has the adverse effect of reducing levels of T4 in the blood?
Amiodarone
Propranolol
Phenytoin
Theopylline
When prescribing levothyroxine, which statement is true?
This drug is actually a mixture of T3 and T4
Some patients are allergic to the foreign (animal) protein
Dosage adjustments should be made every 7 days until TSH is normal
A lower than usual dosage should be started in cardiac patients
Which of the following drugs blocks iodine uptake by the thyroid gland, resulting in decreased hormone production?
Amiodarone (pacerone)
Carbamazepine (tegretol)
Lithium (Eskalith)
Propranolol (inderal)
What drug may cause thyrotoxicosis?
Amiodarone (Cordarone)
Carbamazepine (tegretol)
Lithium (eskalith)
Propranolol (inderal)
Which of these agents would be the preferred treatment for a child diagnosed with hyperthyroidism?
Methimazole
Propylthiouracil
Radioactive iodine
Potassium iodide
Liothyronine (Cytomel) is NOT the preferred drug for chronic treatment of hypothyroidism because:
Cytomel cannot be used in children or in pregnancy
Cytomel commonly produces allergic hypersensitivity reactions
Serum levels of Cytomel fluctuate, making stabilization of its dose difficult
D.Cytomel must be given TID
When using thiazolidinediones to manage diabetes, which lab test should be monitored to detect adverse effects (ADRs) from this drug?
CBC
Lipid Profile
Liver Tests
TSG
Which antidiabetic medication has the potential to cause acute pancreatitis?
Sitagliptin (Januvia)
Acarbose (precose)
Repaglinide (prandin)
Glimiperide (amaryl)
When considering DPP-4 therapy for T2DM, which one is indicated for patients with renal dysfunctions?
Alogliptin (Nesina)
Linagliptin (tradjenta)
Saxogliptin (onglyza)
Sitagliptin (januvia)
Which of the following preparations are indicated for patients with gastroparesis?
Exenatide (Byetta)
Insulin regular (Humulin R, Novolin R)
Pramlintide (Symlin)
Sitagliptin (Januvia)
Which of the following drug classes utilized in treating Type 2 DM are considered nephroprotective?
Alpha-glucoseidase inhibitors
Meglitinides
Selective sodium glucose co-transorter 2 (SGLT-2)
Thiazolidinediones
Which of the following drug classes is used to treat Diabetes Type 2 have a disadvantage of genitalmycotic infections?
Alpha-glucosidated inhibitors
Biguanides
Dipeptidyl peptidate-4 inhibitors
Sodium glucose co-transporter inhibitors
Which of the following drug classes is most likely to cause hypoglycemia as monotherapy to treat patients with Type 2 diabetes?
Alpha glucosidase inhibitor drugs
Biguanides
Sulfonylureas
Thiazolidinediones
Which of the following agents used to treat T2DM work by reducing hepatic glucose production?
Alpha-glucosidase inhibitors (acarbose)
Meglitinides (Prandin, starlix)
Sulfonylureas (amaryl)
Thiazolidinediones
Which of the following agents is recommended for treating patients with either type 1 or type 2 DM?
Biguanides
Insulin
Meglitinides
Thiazolidinediones
Which of the following ORAL agents are indicated to be administered to an adolescent with type 2 DM?
Meglitinides (Prandin)
Metformin (glucophage)
Selective sodium glucose co-transporter 2 (Invokana)
Sulfonylureas (glimiperide)
All of the following metformin combinations are approved to use except:
Acarbose
Gliptins
Sulfonylureas
Thiazolidinediones
Which of the following GLP-1 analogs or antagonists can be administered less frequently than once or twice daily?
Lixisenatide (Adjyxin)
Dulaglutide (Trulicity)
Exenatide (Byetta)
Liraglutide (Victoza)
When using protease inhibitors to treat patients infected with HIV
Can be used as monotherapy for the disease
Can be administered both orally as well as injectable
May be prescribed in combination with another protease inhbitor
Have the lowest cost of the available anti-retrovirals
There are a number of oral agents used in Type 2 DM. Which are not metabolized by the liver?
Meglitinides
Metformin
Sulfonylureas
Thiasolidinediones
Which of the following corticosteroids LACK mineralocorticoid activity?
Cortisone
Hydrocortisone
Prednisone
Triamcinolone
Which statement is true regarding prolonged corticosteroid therapy?
Chronic use does not increase the risk of adverse drug reactions
There is no risk of topical applications being absorbed systematically
A taper of dosage may be required upon discontinuation of prolonged therapy
Only patients with adrenal insufficiency should be treated chronically
Which of the following regimens used in hormone replacement therapy (HRT) is associated with more hot flashes
Estrogen 0.625 + Medroxyprogesterone 2.5 mg DAILY
Estrogen 0.625 + Microized Progesterone 100mg DAILY
Estrogen 0.625 DAILY + Medroxyprogesterone 5mg daily for 14 days
Estrogen 0.625 + Progestin Monday through Friday
When discussing the possibility of postmenopausal estrogen replacement therapy (ERT) with a patient, which statement is true?
Increases a woman’s risk of developing breast cancer
Can greatly increase serum levels of low density lipoprotein
Requires monitoring of liver function
Contraindicated as monotherapy in women who have has a hysterectomy
Which of the following agents for prevention and management of vulvovaginal atrophy and dryness functions as both an estrogen agonist and antagonist?
Low dose oral estrogen from either plant or animal origin (Cenestin, Premarin)
Estradiol vaginal cream (estrace)
Estradiol vaginal ring (estring)
Ospemifene (Osphena)
The use of ERT/HRT has demonstrated beneficial effects in the following comorbidities EXCEPT:
Cardiac disease
Colon cancer
Osteoporosis
Vasomotor and aginal atrophy
Oral contraceptives can be combinations of synthetic estrogens and synthetic progestins. Which of the following is a synthetic estrogen?
Levonorgestrel
Ethinyl estradiol
Noresthindrone
Ethylnodiol dicetate
An advantage to the use of IM medroxyprogesteribe acetate (Depo-provera) for contraception is?
Its infrequent dosing schedule improves patient compliance
Can be safely used in women with a past history of thrombo-embolic disease
The contraceptive effects can be immediately reversed by giving high dose oral estrogens
It can be used as a “morning after” injection to prevent ovulation
Which of these estrogen replacement products is associated with the least risk for endometrial hyperplasia?
Conjugated synthetic estrogen-A (Cenestin)
Conjugated Estrogen (Premarin)
Estrogen Vaginal Cream (Estrace)
Estradiol Transdermal Patch (Menostar)
Which of the following penicillin products can be administered on an INFREQUENT basis (once daily or less frequent)?
Penicillin G aqueous (pfzerpen)
Amoxicillin (Amoxil)
Penicillin G benzathine (Bicillin)
Penicillin V potassium (V-cillin-K)
Which of the following agents utilized to treat vulvovaginal atrophy and dryness show no increased risk of CHF, breast cancer, or endometrial cancer?
Phytoestrogens
Oral estrogens
Oral progestin
Vaginal estrogen
Contraindications to giving MMR vaccine include:
Pregnancy
Patients with AIDS
Hypersensitivity to thimerosal
Age below 12 yo
Corticosteroids are used for inflammation. When treating nephrotic syndrome with corticosteroids which agent is preferred?
Cortisone
Dexamethasone (decadron)
Hydrocortisone (Cortef)
Prednisone (deltasone)
Corticosteroids are used for inflammation. Which of the following are used by various formulations for inflammatory bowel disease?
Cortisone (generic)
Dexamethasone (decadron)
Hydrocortisone (cortef)
Predinisonolone (prelone)
Due to resistance, which of the following antimicrobials is no longer recommended in the US for empirical treatment of UTIs?
Amoxicillin (Amoxil)
Amoxicillin clavulanate (augmentin)
Cefuroxime axetil (ceftin)
Nitrofurantoin (macrodantin)
For patients with a diagnosis of sinusitis which is the first line antimicrobial choice in a pediatric patient:
Amoxicillin for 10-14 days
Amoxicillin-clavulanate for 7-10days
Respiratory fluoroquinolone for 3 days
Beta-lactamase stable cephalosporin
In a 4 year old child who has a suspected methicillin sensitive S. Aureus pneumonia what is the drug of choice?
Azithromycin (Zithromax)
Cephalexin (keflex)
Erythromycin (EES)
Doxycyclene (vibramycin)
T4 is converted to T3 peripherally. Which condition or agent STIMULATES this conversion?
Amiodarone (Codarone)
Cold temperatures
Starvation
Propranolol (inderal)
Which of the following thyroid products is more likely to produce cardiotoxicity?
Desiccated thyroid
Levothyroxine
Liotrix
Liothyronine
Which of the following insulin products used preprandially has the slowest onset of action?
Insulin aspart (Novolog, Fiasp)
Insulin gluisin (apidra)
Insulin lispro (admelog, humalog)
Insulin regular (Humulin R, novolin R)
Which of the following antifungals LACKS efficacy in topical dermatophytic infections?
Clotrimazole (lotrimin, Mycelex)
Fluconazole (Diflucan)
itraconazole (sporanox)
Miconazole (monistat)
Which of the following hypoglycemic agents has the highest risk for hypoglycemia when administered with metformin?
DPP-4
GLP-1
Regular Insulin
Thiazolidinediones
Antivirals are used in treating HIV/AIDS. Which agent has the potential for severe anemia and/or ganulocytopenia?
Abacavir (ziagen)
Lamivudine (epivir)
Stavudine (Zerit)
Zidovudine (retrovir)
Which of the following antibacterials has utility in treating anaerobic infections?
Azithromycin (zithromax)
Levofloxacin (Levequin)
Metronidazole (flagyl)
Penicillin VK (Vcillin K)
Which of the following vaccines are required for the incoming college freshmen living in dorms receive?
Haemophilius b
Hepatitis A
Hepatits B
Meningococcal
Adverse effects associated with corticosteroid administration include:
Improvements in wound healing
Decreased uric acid secretion
Increased serum calcium levels
promotion of gastric acid secretion
Which of the following would be considered advantages in the use of intermediate-acting glucocorticoid drugs?
No impact on blood sugar levels
No impact on blood pressure
No impact on weight
Potent anti-inflammatory effects
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