Medicinal | Lec 5-8 Assessment | 12Q

A detailed illustration of chemical structures and medicinal compounds, featuring vibrant colors and annotations highlighting various pharmacological elements.

Medicinal Chemistry Assessment

Test your knowledge and understanding of key concepts in medicinal chemistry with our comprehensive quiz focused on latest advancements and critical evaluations in the field.

This quiz includes topics such as:

  • Pharmacology
  • Drug mechanisms
  • Side effects and interactions
  • Drug design and development
12 Questions3 MinutesCreated by ThinkingMolecule42
Was developed by Bioisosteric modification
Has minimal CNS side effects
Has marked antiserotonin activity
Sa potent second generation antihistamine
The 3-phenolic OH greatly enhanced activity
It is a ureceptor antagonist and k receptor agonist
It belongs to benzomorphans
It shows hallucinogenic side effect results from its binding to a non- opioid receptor
Au+ is attached to Sulfur
Au+ is easily converted to its oxidized form
Monovalent gold
Orally bioavailable
Carboxamide NH Contributes to increasing its acidity
4-hydroxy group is not essential for activity
It is an isostere of piroxicam
Pyridyl nitrogen contributes to enolate stabilization
Is a powerful agonist at the 3 types of opioid receptors
Its mirror image has a completely different pharmacological action
It is an active metabolite of an opioid drug
Has 2 stereocenters, only R,R isomer is an opioid agonist
Ri = CH3, R2 = H, R3= heteroaryl
R1= H, R2= H, Ra= heteroaryl
Ri = CH3, R2= CH3, Ra= heteroaryl
R, = H Rz= CH3, R3= heteroaryl
Which of the following is/are true about coxibs
All of the following are correct
The sulfamoyl or sulfonyl moiety provides target selectivity
Are class of selective COX-1 inhibitors
Show Gl side effects that hindered their potential clinical usefulness
Binds to delta receptors causing hallucination
Is a weak K agonist
Is a weak µ agonist
Has powerful analgesic activity with low risk of addiction
Belongs to biologic DMARDs
Is an interleukin-1 antagonist
Stabilizes mast cells
Decreases expression of B-cells and T-cells
5-fluoro substituent improved metabolic stability
Indene ring enhanced anti-inflammatory potency
Sulfinyl group decreased side effect and increased water solubility
2-CH3 group ensures trans like conformation
Ethylene diamine derivatives
Ethanolamine ethers
Propylamine analogs
Phenothiazine Derivatives
Binds weakly to all types of opioid receptors
Cannot bind to µ receptor
Its side effect results from its binding to a non-opioid receptor
S a powerful k agonist
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