Test your knowledge of functional high-risk multiple myeloma

Which of the following criteria best defines Mr. S.'s functional high-risk multiple myeloma at the time of first relapse?

Relapse occurring with a del17p clone

Relapse occurring with an elevated M spike and anemia

Relapse occurring after triple-drug induction and ASCT

Relapse occurring within 12 months of frontline autologous stem cell transplantation

Based on his initial labs and cytogenetics, what was Mr. S.'s R-ISS stage at diagnosis, and what was the corresponding approximate median overall survival (OS) in the original R-ISS report?

R-ISS I; Median OS approximately 83 months

R-ISS II; Median OS approximately 45 months

R-ISS II; Median OS approximately 62 months

Initiate corticosteroids (e.g., methylprednisolone) alone

Mr. S. developed grade 2 cytokine release syndrome (CRS) on day 4 after receiving his BCMA-directed CAR T-cells. What is the standard first-line management for Grade 2 CRS?

Observation and supportive care alone

Initiate tocilizumab in combination with supportive care

Initiate tocilizumab and high-dose dexamethasone

Initiate corticosteroids (e.g., methylprednisolone) alone

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