Protein Sorting and Intracellular traffic

Which of these are roles of the smooth endoplasmic reticulum

Synthesis of non-cytosolic proteins

Storage and release of calcium ions

Detoxification

SnoRNPs

What binds to the signal sequence of a synthesising peptide to allow it to synthesise 'into' the endoplasmic reticulum

Signal recognition particle receptor

Chaperones

T snares

Signal recognition particle

N-linked glycosylation involves

Oxygen

Signal sequences

Asparagine side chain

Mannose

After cleavage of 3 glucose and 1 mannose, what is added to incorrectly folded proteins

Glucose

RabGTP

RanGTP

Externally transcribed spacers

After this glucose has been added, it binds to what to cause editing of unsuccessful protein formation

Mannose-6-phosphate

COP I

Calnexin

COP II

Which of these are actions of the unfolded protein response (upon accumulation of misfolded proteins in ER)

Clathrin is associated to vesicles that are from

The ER

The Golgi body

Endocytosis

RabGTP (Rabs being specific to membrane types) binds to

Tether protein

V snare

T snare

BiP

RabGTP is converted to RabGDP upon membrane fusion (by RabGAP), which is then bound to

RabGEF

RabGDI

COP I

COP II

When two or more vesicles bind together it forms a(n)

Endosome

Vesicular tubular cluster

Lysozome

A mannose-6-phosphate 'tag' can be added to vesicles to cause

Transport to lysozome

Transport to endosome

Transport to cell membrane

Transport to SER

The two types of exocytosis are

Regulated

Hormonal

Docking

Consituitive

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