MDRV4: Hemoglobin: Just Relax Already

A dog with IMHA (immune mediated hemolytic anemia) breathing room air (21% FiO2) has a hemoglobin of 5g/dL with normal lung function (PaO2 95mmHg, SaO2 of 97%). The dog is supplemented to 60% FiO2, raising the PaO2 to 270 mmHg and the SaO2 to 100%. The change in oxygen content of the arterial blood is:

A. +0.7mL/dL

B. +6.9 mL/dL

C. +7.6 mL/dL

D. +20.9 mL/dL

2. Which of the following would be expected to favor the tense (T) conformation of hemoglobin, assuming PaO2 is static?

A. pH increasing to 7.5

B. Temperature increasing 1 Degrees Celsius

C. Decreased synthesis of 2,3 BPG

D. An amino acid mutation that changes the p50 from 29 to 27 mmHg.

3. Increasing protonation of amino acid residues on the hemoglobin molecule that favors reduce affinity for oxygen is an example of the:

A. Bohr effect

B. Haldane effect

C. Hamburger effect

D. P50 effect

4. Replacement of the 2 β globins of hemoglobin with 2y globins is expected to result in:

A. Right shifting of the oxyhemoglobin dissociation curve

C. Increase affinity of Hb for oxygen

D. No change in oxygen carry capacity at a given PaO2

B. Conformation change favoring the tense state

Both COHb and MetHb result in:

A. Falsely normal pulse ox readings

B. Normal pink/red appearance to mucous membranes

C. The need for high levels of O2 supplementation to return Hb to a normal state

D. Higher O2 affinity of affected molecules

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MDRV4: Hemoglobin: Just Relax Already

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