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Metabolism

Tacrolimus
Neutropenia, diarrhea
Severe myelosuppression
Increase MI, mortality, stent thrombosis
Opioid toxicity
CNS (neutrotoxity, liver injury)
Decreased efficacy
Shorter disease and relapse free time, decreased survival
Bleeding
Cutaneous
Myopathy
Neurotoxity (seizure, neuropathy), hepatoxcity
Chronic renal toxicity
Tamoxifen
Neutropenia, diarrhea
Severe myelosuppression
Increase MI, mortality, stent thrombosis
Opioid toxicity
CNS (neutrotoxity, liver injury)
Decreased efficacy
Shorter disease and relapse free time, decreased survival
Bleeding
Cutaneous
Myopathy
Neurotoxity (seizure, neuropathy), hepatoxcity
Chronic renal toxicity
Codeine
Neutropenia, diarrhea
Severe myelosuppression
Increase MI, mortality, stent thrombosis
Opioid toxicity
CNS (neutrotoxity, liver injury)
Decreased efficacy
Shorter disease and relapse free time, decreased survival
Bleeding
Cutaneous
Myopathy
Neurotoxity (seizure, neuropathy), hepatoxcity
Chronic renal toxicity
Warfarin
Neutropenia, diarrhea
Severe myelosuppression
Increase MI, mortality, stent thrombosis
Opioid toxicity
CNS (neutrotoxity, liver injury)
Decreased efficacy
Shorter disease and relapse free time, decreased survival
Bleeding
Cutaneous
Myopathy
Neurotoxity (seizure, neuropathy), hepatoxcity
Chronic renal toxicity
Plavix
Neutropenia, diarrhea
Severe myelosuppression
Increase MI, mortality, stent thrombosis
Opioid toxicity
CNS (neutrotoxity, liver injury)
Decreased efficacy
Shorter disease and relapse free time, decreased survival
Bleeding
Cutaneous
Myopathy
Neurotoxity (seizure, neuropathy), hepatoxcity
Chronic renal toxicity
Efavirenz
Neutropenia, diarrhea
Severe myelosuppression
Increase MI, mortality, stent thrombosis
Opioid toxicity
CNS (neutrotoxity, liver injury)
Decreased efficacy
Shorter disease and relapse free time, decreased survival
Bleeding
Cutaneous
Myopathy
Neurotoxity (seizure, neuropathy), hepatoxcity
Chronic renal toxicity
Nevirapine
Neutropenia, diarrhea
Severe myelosuppression
Increase MI, mortality, stent thrombosis
Opioid toxicity
CNS (neutrotoxity, liver injury)
Decreased efficacy
Shorter disease and relapse free time, decreased survival
Bleeding
Cutaneous
Myopathy
Neurotoxity (seizure, neuropathy), hepatoxcity
Chronic renal toxicity
Irinotecan
Neutropenia, diarrhea
Severe myelosuppression
Increase MI, mortality, stent thrombosis
Opioid toxicity
CNS (neutrotoxity, liver injury)
Decreased efficacy
Shorter disease and relapse free time, decreased survival
Bleeding
Cutaneous
Myopathy
Neurotoxity (seizure, neuropathy), hepatoxcity
Chronic renal toxicity
Isoniazid
Neutropenia, diarrhea
Severe myelosuppression
Increase MI, mortality, stent thrombosis
Opioid toxicity
CNS (neutrotoxity, liver injury)
Decreased efficacy
Shorter disease and relapse free time, decreased survival
Bleeding
Cutaneous
Myopathy
Neurotoxity (seizure, neuropathy), hepatoxcity
Chronic renal toxicity
Thiopurines
Neutropenia, diarrhea
Severe myelosuppression
Increase MI, mortality, stent thrombosis
Opioid toxicity
CNS (neutrotoxity, liver injury)
Decreased efficacy
Shorter disease and relapse free time, decreased survival
Bleeding
Cutaneous
Myopathy
Neurotoxity (seizure, neuropathy), hepatoxcity
Chronic renal toxicity
Metformin
Neutropenia, diarrhea
Severe myelosuppression
Increase MI, mortality, stent thrombosis
Opioid toxicity
CNS (neutrotoxity, liver injury)
Decreased efficacy
Shorter disease and relapse free time, decreased survival
Bleeding
Cutaneous
Myopathy
Neurotoxity (seizure, neuropathy), hepatoxcity
Chronic renal toxicity
Simvastatin
Neutropenia, diarrhea
Severe myelosuppression
Increase MI, mortality, stent thrombosis
Opioid toxicity
CNS (neutrotoxity, liver injury)
Decreased efficacy
Shorter disease and relapse free time, decreased survival
Bleeding
Cutaneous
Myopathy
Neurotoxity (seizure, neuropathy), hepatoxcity
Chronic renal toxicity
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