Test Quiz

Which member of the suite are you?

How Well do you Know TayTay

Do you have any recommendations in new papers today?

Predisposing factors • Multiple drug therapy • Age == Elderly == Neonates- chloramphenicol, morphine, Reye’s syndrome - ? Hepatotoxicity – Aspirin Predisposing factors • Gender - Females have 1.5-1.7 folds of developing ADR than males - Women are prone to develop blood dyscrasias with phenylbutazone & chloramphenicol • Presence of disease - HIV –skin reactions with co-trimoxazole Predisposing factors • Race and genetic polymorphism - Drug-metabolizing enzymes (poor, extensive & ultra-rapid metabolizers) - Drug receptors - Drug transporters (P-glycoproteins, P-gp ) Mechanism of dose related (Type A) reactions • Pharmaceutical cause -pharmaceutical aspects of a dosage form Indomethacin – GI bleeding Mechanism of dose related (Type A) reactions • Pharmacokinetic causes 1. Absorption GI motility, gastric contents, disease, absorption in the GI tract, first-pass metabolism in liver & gut wall, concomitant drugs 2. Distribution Plasma-protein and tissue binding Mechanism of dose related (Type A) reactions • Pharmacokinetic causes 3. Metabolism Enzyme induction or inhibition – efficacy?? Genetic variants – oxidation, hydrolysis, acetylation Drugs competing for glucuronidation 4. Elimination -digoxin Examples of type B * Anesthetics e.g. Halothane and succinylcholine cause Malignant hyperthermia treated with dantrolene © Chronic type • paracetamol hepatotoxicity

Weather Instruments and Their Uses - Free Online

Charlie and Lola Character - Which One Are You?

What Will My Baby Look Like? Free Baby Face

Honkai Impact 3rd Weekly - Test Your HI3 Knowledge

Any Two Lines Lie in Exactly One Plane? True/False

Thigh Muscle - Free Anatomy Practice

Hunter x Hunter - Free Fan Trivia Challenge

What Are His Intentions - Free, Instant Results