Study of substances that interact with living systems through chemical processes, especially by binding to regulatory molecules and activating or inhibiting body processes
Pharmacogenomics
Pharmacology
Toxicology
Pharmacognosy
Any substance that brings about a change in the biologic function through its chemical action
Drugs
Poison
Medicine
Active Ingredient
This chemical receptor interacts directly with the drug
Antagonist
Agonist
Receptors
Chemical Antagonist
Drugs that have almost exclusive harmful effects
Overdosage
Poisons
Toxins
Biologic Drugs
More active enantiomer at one type of receptor site may not be more active at another receptor type
Carvedilol
Stereoisomers
Nadolol
Racemic Mixtures
Which is incorrect?
D+R -> drug-receptor-effector complex -> effect
D + R -> drug-receptor complex -> effector molecule -> effect
D + R -> D-R molecule -> deactivation of coupling molecule -> effector molecule -> effect
Inhibition of metabolism of endogenous activator -> increased activator action on an effector molecule -> increased effect
Which does not describe receptors?
Receptors are proteins
Responsible for non-selective drug action
Determine the quantitative relations between dose or conc. Of drug & pharmacologic effects
Mediate the actions of pharmacologic agonists & antagonists
Transport proteins are the ff, except
Chloride channel
Na/K ATPase
Na channels
Calcium channel
Drug responsible for myasthenia gravis
Betanechol
Physostigmine
Pyridostigmine
Echothiophate
Cardiac arrest
Carvedilol
Epinephrine
Atropine
Nadolol
Weight reduction
Amphetamines
Metaproterenol
Phenylephrine
Epinephrine
Dopamine at intermediate-dose action
Increased heart rate and decreased contractility
Increased contractility and heart rate
Vasodilation
Vasoconstriction
Urinary incontinence
Ritodrine
Ephedrine
Cocaine
Oxymetazoline
Drug interaction of Tyramine with MAO Inhibitors
Decreased BP
Decreased contractility
Increase BP
Increased contractility
Non-selective adrenergic antagonist beta blockers
Metoprolol
Labetalol
Propranolol
Nadolol
ACh is synthesize from___________ and __________by choline acetyltransferase (write answers in small letters) Lagyan mo ng comma every after answer
Inhibits the release of ACh
Hemicholinium
Vesamicol
Botulinum Toxin
Norepinephrine
Primary transmitter at the sympathetic postganglionic synapses
Epinephrine
Acetylcholine
Muscarine
Norepinephrine
Which is true about Adrenergic Transmission synthesis and storage
NE and dopamine are transported into vesicles and stored
MAO INHIBITORS may decrease stores
RESERPINE allows the transport
MAO activates portions of the NTA in the cytoplasm
State all adrenergic antagonist beta-blockers with ISA (write answers in small letters) Lagyan mo ng comma every after answer
Adrenergic Antagonist beta - blockers with local anesthetic action (write answers in small letters) Lagyan mo ng comma every after answer
Mixed alpha & beta blocker
Phenoxybenzamine
Terazosin
Nadolol
Carvedilol
Adrenergic Antagonist Selective beta-blockers (write answers in small letters) Lagyan mo ng comma every after answer
Mydriatic
Amphetamines
Dopamine
Phenylephrine
Epinephrine
Acts on muscarinic R
Lobeline
Pilocarpine
Neostigmine
Edrophonium
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