Study of substances that interact with living systems through chemical processes, especially by binding to regulatory molecules and activating or inhibiting body processes

Pharmacogenomics

Pharmacology

Toxicology

Pharmacognosy

Any substance that brings about a change in the biologic function through its chemical action

Drugs

Poison

Medicine

Active Ingredient

This chemical receptor interacts directly with the drug

Antagonist

Agonist

Receptors

Chemical Antagonist

Drugs that have almost exclusive harmful effects

Overdosage

Poisons

Toxins

Biologic Drugs

More active enantiomer at one type of receptor site may not be more active at another receptor type

Carvedilol

Stereoisomers

Nadolol

Racemic Mixtures

Which is incorrect?

D+R -> drug-receptor-effector complex -> effect

D + R -> drug-receptor complex -> effector molecule -> effect

D + R -> D-R molecule -> deactivation of coupling molecule -> effector molecule -> effect

Inhibition of metabolism of endogenous activator -> increased activator action on an effector molecule -> increased effect

Which does not describe receptors?

Receptors are proteins

Responsible for non-selective drug action

Determine the quantitative relations between dose or conc. Of drug & pharmacologic effects

Mediate the actions of pharmacologic agonists & antagonists

Transport proteins are the ff, except

Chloride channel

Na/K ATPase

Na channels

Calcium channel

Drug responsible for myasthenia gravis

Betanechol

Physostigmine

Pyridostigmine

Echothiophate

Weight reduction

Amphetamines

Metaproterenol

Phenylephrine

Epinephrine

Dopamine at intermediate-dose action

Increased heart rate and decreased contractility

Increased contractility and heart rate

Vasodilation

Vasoconstriction

Drug interaction of Tyramine with MAO Inhibitors

Decreased BP

Decreased contractility

Increase BP

Increased contractility

Non-selective adrenergic antagonist beta blockers

Metoprolol

Labetalol

Propranolol

Nadolol

ACh is synthesize from___________ and __________by choline acetyltransferase (write answers in small letters) Lagyan mo ng comma every after answer

Inhibits the release of ACh

Hemicholinium

Vesamicol

Botulinum Toxin

Norepinephrine

Primary transmitter at the sympathetic postganglionic synapses

Epinephrine

Acetylcholine

Muscarine

Norepinephrine

Which is true about Adrenergic Transmission synthesis and storage

NE and dopamine are transported into vesicles and stored

MAO INHIBITORS may decrease stores

RESERPINE allows the transport

MAO activates portions of the NTA in the cytoplasm

State all adrenergic antagonist beta-blockers with ISA (write answers in small letters) Lagyan mo ng comma every after answer

Adrenergic Antagonist beta - blockers with local anesthetic action (write answers in small letters) Lagyan mo ng comma every after answer

Mixed alpha & beta blocker

Phenoxybenzamine

Terazosin

Nadolol

Carvedilol

Adrenergic Antagonist Selective beta-blockers (write answers in small letters) Lagyan mo ng comma every after answer

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