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Test your knowledge of avapritinib response in PDGFRA exon 18 GIST management

Which specific PDGFRA mutation is known to confer resistance to imatinib therapy?

Exon 18 missense variant

Exon 12 mutation

Wild-type PDGFRA

PDGFRA D842v mutation

Adjuvant therapy is recommended for gastrointestinal stromal tumors (GISTs) confirmed to harbor a PDGFRA mutation.

True

False

In GIST cases driven by a PDGFRA mutation, approximately 80% of these mutations are found in which specific exon?

Exon 12

Exon 14

Exon 18

Exon 17

Avapritinib is a tyrosine kinase inhibitor (TKI) approved for use against PDGFRA-mutated GISTs, demonstrating efficacy in the phase I NAVIGATOR trial. What is the recommended neoadjuvant therapy dose for avapritinib?

100 mg daily

300 mg daily

400 mg daily

600 mg daily

0

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