Management usmle

5) A 1-month-old infant is brought to the office for a routine neonatal visit. His prenatal and birth histories are unremarkable. His vital signs are normal. Examination reveals a harsh, loud holosystolic murmur over the left, lower sternal border. Palpation reveals a thrill over the precordial region. There is no cyanosis, and pulmonary auscultation reveals no rales. Chest radiograph reveals a heart of normal size and a slight increase in pulmonary vascularity. EKG is normal. Which of the following is the most appropriate course of action?
. PGE 1 administration
. Oxygen administration
. Digoxin and diuretic therapy
. Surgical repair
. Reassurance
25) A 12-year-old boy comes to the emergency department complaining of vague left-sided chest discomfort. Two months ago, he was involved in a high-speed motor vehicle accident but sustained only minor injuries. He was observed in the emergency department overnight and discharged home. His past medical history is otherwise unremarkable. Vital signs are normal. Auscultation of the lungs shows decreased air entry into the left lower base. An x-ray of the chest is shown below. Which of the following is the most appropriate next step in management of this patient?
 
A
. Chest tube placement
. Computed tomography scan of the chest and abdomen
. Flexible bronchoscopy
. Intravenous antibiotics
. Reassurance and outpatient follow-up
25) A 12-year-old boy comes to the emergency department complaining of vague left-sided chest discomfort. Two months ago, he was involved in a high-speed motor vehicle accident but sustained only minor injuries. He was observed in the emergency department overnight and discharged home. His past medical history is otherwise unremarkable. Vital signs are normal. Auscultation of the lungs shows decreased air entry into the left lower base. An x-ray of the chest is shown below. Which of the following is the most appropriate next step in management of this patient?
 
A
. Place chest tube
. Bronchoscopy
. Start antibiotics
. Barium swallow
. Angiogram
26) A 12-year-old boy comes to the emergency department with severe shortness of breath, cough, and fever. He was diagnosed with cystic fibrosis when he was five years old. He is currently not taking any medications. His temperature is 39.4 C (103F), blood pressure is 80/40 mmHg, pulse is 120/min, and respirations are 30/min. He is excessively using his accessory respiratory muscles. Lung auscultation reveals bilateral lower lobe crackles and expiratory wheezing. Pulse oximetry shows Sa02 of 85% that improves to 92% after oxygen supplementation. Which of the following antibiotics or combinations is the best choice for this patient?
Intravenous ceftazidime and gentamicin
Intravenous vancomycin and gentamicin
Intravenous imipenem/cilastatin
Intravenous clindamycin
Oral ciprofloxacin
32) A 12-year-old boy presents with an intensely pruritic rash for 3 days. He just went on a camping trip, during which he wore only short-sleeve shirts and short pants. His temperature is 37.6 C (99.7 F), blood pressure is 96/62 mm Hg, pulse is 65/min, and respirations are 12/min. There are numerous erythematous papules and vesicles on both arms and legs. Most of them are in a linear array. Which of the following is the most appropriate pharmacotherapy?
Oral cephalexin
Oral prednisone
Topical diphenhydramine
Topical mupirocin
Topical 1% hydrocortisone
35) A 12-year-old girl is seen by a pediatrician for a mild case of pneumonia. She is treated with an intramuscular injection of penicillin. About 15 minutes later, she develops extreme itchiness, accompanied by the development of wheals scattered over her chest and extremities. She also begins to wheeze and complain of difficulty breathing. The color of her lips and face remains rosy. Which of the following is the most appropriate first step in management?
Epinephrine injection
IV corticosteroids
Intubation
Oral corticosteroids
No specific therapy is needed
36) A 12-year-old girl presents with a 2-month history of vaginal discharge. She describes it as clear and states that it stains her underwear. She says that she hates boys, and that "no way" has she ever had sex or even kissed a boy. She reports having had developing breasts for 2 years and thinks that her growth spurt was about a year ago. Genital findings include a pubic hair stage of Tanner III with no evidence of redness or irritation of the vulvovaginal area. A slight amount of odorless, clear mucus is seen. Microscopic examination of the mucus reveals epithelial cells and a few bacteria, but no white cells. The pH is between 3.5 and 4. Which of the following is the most appropriate next step in management?
No treatment, but the girl should be reassessed in a few months
Advise the girl to discontinue all bubble baths and wipe herself front to back after voiding
Pelvic examination to obtain cultures for gonorrhea and Chlamydia
Clotrimazole cream to be applied once a day for 10 days
Sitz baths one or two times a day and 1% hydrocortisone cream applications once a day for a week
38) A 12-year-old girl with a history of asthma has been admitted to intensive care units two times in the past and has had three emergency department visits during the past 12 months. Her only medication is inhaled albuterol as needed, and she uses it two to three times a day. She has nocturnal symptoms about two times a week. She is free of symptoms now but reports that she gets short of breath easily. Which of the following pharmacologic interventions is most appropriate?
. Anticholinergic agent
. Cromolyn sodium
. Inhaled corticosteroid
. Long-term bronchodilator
. Nedocromil sodium
40) A 12-year-old male is brought to the physician because of a two week history of right groin pain and limping. He is at the 60th percentile for height and the 90th percentile for weight. He is afebrile and his other vital signs are within normal limits. Examination shows the range of motion of the right knee joint is within normal limits, but hip movements are restricted and the right foot points medially. There is marked external rotation of the right thigh on flexion of the hip. After confirming the diagnosis, which of the following is the most appropriate management?
. Aspiration and microscopic examination of the hip joint synovial fluid
. Conservative management with rest and analgesics
. Closed reduction of the hip joint
. Immediate osteotomy of the femoral neck
. External fixation of the hip joint with pins
43) A 13-year-old girl presents with a 1-week history of a sore throat and a nonproductive cough. She has been previously healthy and has not been exposed to any other sick person. She has not been taking any medications. On examination, she has normal oxygen saturation and a low-grade fever. The remainder of the examination is unremarkable. Which of the following is the most appropriate pharmacotherapy?
Amoxicillin
Cefazolin
Erythromycin
Metronidazole
Trimethoprim-sulfamethoxazole
46) A 14-year-old boy is brought to medical attention because of nasal fullness and bleeding. Inspection reveals enlarged cervical lymph nodes as well. Biopsy of a lymphnode confirms nasopharyngeal carcinoma. What is the best management strategy for this patient?
. Chemoradiation
. External beam radiation therapy
. Intracavitary radiation therapy
. Surgical resection
. Surgical resection followed by adjuvant chemoradiation
64) A 15-year-old girl with type 1 diabetes mellitus presents to her primary care doctor for a routine checkup. Perusal of her blood sugar chart indicates that her recorded blood glucose levels are routinely between 120 and 150 mg/dL before breakfast, dinner and bedtime, with the normal being 116 mg/dL. She is on NPH and regular insulin. Which of the following is the next appropriate step?
. Decrease the dosage of NPH
. Decrease the dosage of Regular insulin
. Make no changes and obtain a glycosylated Hb test
. Increase the dosage of NPH
77) A 16-year-old G1P0 at 38 weeks gestation comes to the labor and delivery suite for the second time during the same weekend that you are on call. She initially presented to labor and delivery at 2:00 PM Saturday afternoon complaining of regular uterine contractions. Her cervix was 1 cm dilated, 50% effaced with the vertex at −1 station, and she was sent home after walking for 2 hours in the hospital without any cervical change. It is now Sunday night at 8:00 PM, and the patient returns to labor and delivery with increasing pain. She is exhausted because she did not sleep the night before because her contractions kept waking her up. The patient is placed on the external fetal monitor. Her contractions are occurring every 2 to 3 minutes. You reexamine the patient and determine that her cervix is unchanged. Which of the following is the best next step in the management of this patient?
Perform artificial rupture of membranes to initiate labor
. Administer an epidural
. Administer Pitocin to augment labor
. Achieve cervical ripening with prostaglandin gel
. Administer 10 mg intramuscular morphine
88) A 17-year-old adolescent boy is stabbed in the left seventh intercostal space, midaxillary line. He presents to the ER with a heart rate of 86 beats per minute, blood pressure of 125/74 mm Hg, and oxygen saturation of 98%. Breath sounds are equal bilaterally. Which of the following is the most appropriate next step in his workup?
. Local exploration of the wound
. Left tube thoracostomy
. Diagnostic laparoscopy
. CT scan of the abdomen
. Echocardiography
89) A 17-year-old adolescent boy sustains a small-caliber gunshot wound to the mid-epigastrium with no obvious exit wound. His abdomen is very tender; he is taken to the operating room and the bullet appears to have tracked through the stomach, distal pancreas, and spleen. The duct appears to have been injured. Which of the following is the best strategy for the management of this patient’s pancreatic injury?
. Drainage alone
. Roux-en-Y pancreaticojejunostomy
. Pancreaticoduodenectomy
. Frey procedure
. Distal pancreatectomy
100) A 19-year-old female comes to the physician because of left lower quadrant pain for 2 months. She states that she first noticed the pain 2 months ago but now it seems to be growing worse. She has had no changes in bowel or bladder function. She has no fevers or chills and no nausea, vomiting, or diarrhea. The pain is intermittent and sometimes feels like a dull pressure. Pelvic examination is significant for a left adnexal mass that is mildly tender. Urine hCG is negative. Pelvic ultrasound shows a 6 cm complex left adnexal mass with features consistent with a benign cystic teratoma (dermoid).Which of the following is the most appropriate next step in management?
. Repeat pelvic examination in 1 year
. Repeat pelvic ultrasound in 6 weeks
. Prescribe the oral contraceptive pill
. Perform hysteroscopy
. Perform laparotomy
91) A 17-year-old female comes to the physician's office for a routine physical examination. She has no complaints and has no previous medical problems. She has been having sex since the age of 14 and has had 3 sexual partners so far. Vital signs are stable and physical examination is unremarkable. Pap smear is performed and the report came back as "satisfactory for evaluation" and shows mild dysplasia (low grade intraepithelial lesion). Which of the following is the most appropriate next step in management?
. Repeat Pap smear in 2 weeks
. Repeat Pap smear in 12 months
. Reflex HPV testing
. Colposcopy
. Endometrial curettage
108) A 19-year-old man comes to the office and says, "Doctor! I have been having a peculiar problem lately. My stool has a funny color. First, it was black and almost sticky. Yesterday, it became maroon. In fact, today I saw some bright red blood." He denies any associated pain or fever. He is adopted, and his family history is unknown. His vital signs are stable. Physical examination is normal, but his stool is positive for occult blood. Laboratory studies reveal a hematocrit of 29% and hemoglobin concentration of 9.6 g/dL. Colonoscopy reveals hundreds of colonic polyps, which are identified as adenomatous polyps with the biopsy. What is the appropriate recommendation for this patient at this point?
. Reassure the patient as the polyps are most probably benign and have no long-term complications
. Perform regular colonoscopy and biopsy every three years from now on to check for any malignant change
. Start regular colonoscopy and biopsy eight years from now
. The patient needs elective procto-colectomy
. The patient needs close surveillance with regular F OBT and CEA levels
189) A 22-year-old nulliparous woman comes to the physician with lower abdominal pain, nausea, and vomiting. She is unable to keep anything down. She is sexually active and uses oral contraceptive pills. The patient's last menstrual period was 15 days ago. Her temperature is 39C (102.2F), blood pressure is 110/70 mm Hg, and pulse is 110/min. Physical examination shows dry mucous membranes, soft and symmetrical abdomen, and diffuse tenderness over the lower quadrants. External genitalia show no abnormalities; speculum examination shows purulent discharge from the cervical os. The uterus is normal in size but is tender to palpation and motion. The adnexae are markedly tender but no palpable mass is noted. Cervical cultures are pending. Urine pregnancy test is negative. Which of the following is the most appropriate next step in management of this patient?
. Admit the patient and wait for culture results
. Inpatient treatment with cefotetan and doxycycline
. Outpatient treatment with ceftriaxone and doxycycline
. Outpatient treatment with metronidazole and ampicillin
. Outpatient treatment with oral amoxicillin and clavulanic acid
197) A 22-year-old professional basketball player falls on his outstretched hand during a scrimmage game. He has mild swelling at the wrist and tenderness to palpation in the anatomic snuffbox. No fracture is visible on multiple radiographs of the wrist and hand. Which of the following is the most appropriate management of this patient?
. anti-inflammatory medication and application of ice
. Elastic wrist support, analgesics, and restricted activity for 1–2 weeks
. Presumptive diagnosis of a scaphoid fracture, with application of a wrist splint, and repeat x-rays in 10–14 days
. Presumptive diagnosis of a scaphoid fracture, with application of a short-arm cast including the thumb
. Presumptive diagnosis of a scaphoid fracture, application of a short-arm cast including the thumb, and removal of the cast, with repeat x-rays in 10–14 days
214) A 22-year-old woman presents to the emergency department in an agitated state, certain that she is "about to die." Fifteen minutes ago, she developed heart palpitations and a severe "viselike" tightness in her chest. She experienced a similar episode last week, which resolved in twenty minutes. She denies using any drugs and her medical history is unremarkable. Her father has a history of heart disease and her mother has diabetes mellitus. She takes no medications. Vital signs are temperature 37.0°C (98.6°F), blood pressure 132/74 mmHg, pulse 118/min, and respiratory rate 30/min. She is sweating profusely. EKG reveals sinus tachycardia. The most appropriate next step is administration of which of the following?
. Alprazolam
. Aspirin
. Buspirone
. Fluoxetine
. Imipramine
244) A 23-year-old woman presents for evaluation of a 7-month history of amenorrhea. Examination discloses bilateral galactorrhea and normal breast and pelvic examinations. Pregnancy test is negative. Which of the following classes of medication is a possible cause of her condition?
. Antiestrogens
. Gonadotropins
. Phenothiazines
. Prostaglandins
. GnRH analogues
252) A 23-year-old woman, gravida 2, para 1, at 6 weeks' gestation comes to the emergency department because of lower abdominal pain and fevers. She states that her symptoms began 2 days ago and have steadily worsened since. Past medical history is significant for 2 episodes of gonorrhea and 1 episode of chlamydia. Temperature is 38.9 C (102.1 F), blood pressure is 110/76 mm Hg, pulse is 102/min, and respirations are 12/minute. Abdominal examination demonstrates significant lower abdominal tenderness. Pelvic examination shows a mucopurulent cervical discharge and bimanual examination reveals cervical motion tenderness and adnexal tenderness. Complete blood count shows leukocytes 18,000/mm3. Pelvic ultrasound shows a 6-week intrauterine gestation with no adnexal findings. Which of the following is the most appropriate management?
. No treatment is necessary
. Intramuscular ceftriaxone, oral doxycycline, and discharge home
. Intravenous cefotetan and doxycycline and hospital admission
. Intravenous clindamycin and gentamicin and hospital admission
. Laparoscopy
300) A 25-year-old Gl0 with an intrauterine pregnancy (IUP) at 38 weeks' gestation presents to the labor and delivery unit stating that she thinks she is in labor. She has had routine prenatal care. She states that she has generalized abdominal pain that comes and goes. Thepain has been going on for about 5 hours and is starting to become regular. She thinks it is contractions. Vital sign: BP, 115/75 mm Hg; P, 82 beats/min; R, 12 breaths/min; T, 98.6°F. Contractions: Present, Fetal movement: Present, Vaginal bleeding: Absent, Leakage of fluid: Absent. Physical examination: Gen: Awake, alert, oriented x3, mild pain distress, CVS: S1S2 + RRR no m/ r/ g, Lungs: CTA bilaterally, Abd: Gravid, Ext: 1+ edema bilaterally. What is the next step in the management of this patient?
. Digital cervical examination
. Transabdominal US
. Transvaginal ultrasonography (US)
. Nonstress test
. Emergency surgery
338) A 26-year-old man comes with his girlfriend to the emergency department due to a very high fever. He just finished his second cycle of BEP (bleomycin, etoposide, cisplatin) chemotherapy for metastatic seminoma 4 days ago. Other than his fever, he has no complaints. He denies any chest pain, cough, diarrhea or any rash. He stopped smoking ever since he was diagnosed with his "deadly disease," but drinks alcohol occasionally. His temperature is 38.9°C (102°F), blood pressure is 118/70 mm Hg, pulse is 102/min, and respirations are 19/min. Physical examination reveals a pale man without any eyebrows or eyelashes. Chest auscultation is clear. Blood tests reveal: WBC 690/mm3 with 9% neutrophils, Hemoglobin 8.6 g/dl, Hematocrit 25%, Platelets 74,000/mm3. What is the best next step in the management of this patient?
. Give acetaminophen and send him home
. Obtain blood cultures and give cefepime
. Obtain blood cultures and give vancomycin
. Order blood cultures and wait for the results
. Give blood, platelet, and G-CSF transfusion
343) A 26-year-old primigravid woman at 35 weeks' gestation comes to the labor and delivery ward because of painful uterine contractions and a gush of fluid. Sterile speculum examination reveals a pool of clear fluid in the vagina that is nitrazine positive. When the fluid is examined under the microscope, a "ferning" pattern is seen. Cervical examination shows the patient to be 4 cm dilated, 100% effaced, and at 0 station. Fetal fingers can be felt along side the fetal head. External uterine monitoring shows contractions every 2 minutes. External fetal monitoring shows the fetal heart rate to be in the 130s and reactive. Which of the following is the most appropriate next step in management?
. Expectant management
. Oxytocin augmentation
. Forceps delivery
. Vacuum delivery
. Cesarean section
344) A 26-year-old primigravida at 20th week gestation presents to the emergency room with a sudden onset of tearing chest pain radiating to her back and left arm. The patient is pale and diaphoretic. Her PR: 116/min; BP: 192/ 104 mmHg in left arm, and 123/65 mmHg in right arm; RR: 36/min. Her cardiac examination reveals a diastolic murmur along the left sternal border. Her previous prenatal care is not known. She is a smoker with a 10 pack/year history and drinks alcohol. Her ECG reveals mild left axis deviation and ST segment depression in lead II, III, and AVF. What is the most appropriate next step in the management of this patient?
. Obtain CK-MB and Troponin levels
. Transesophageal echocardiogram (TEE)
. Transthoracic echocardiogram (TTE)
. Antihypertensive treatment
. CT scan of chest
346) A 26-year-old woman comes to the physician because of a lump in her vagina. The lump is nontender but is uncomfortable when she walks. She states that for the last 6 years this lump has appeared about once a year. When it occurs she goes to the doctor who puts a catheter into it, which is taken out in a few weeks. She has no other medical problems. She is sexually active with two partners. Examination shows a cystic mass approximately 4 cm in diameter on the right side of the vagina near the hymeneal ring. The mass feels like a discrete cyst. The rest of the pelvic examination is unremarkable. Which of the following is the most appropriate next step in management?
. Expectant management
. Oral antibiotics
. Intravenous antibiotics
. Incision and drainage
. Bartholin's cyst marsupialization
347) A 26-year-old woman comes to the physician for a routine annual visit. She has no complaints. She has no significant previous medical problems. She has been sexually active since the age of 19 with the same partner. They married 4 years ago. She has never had any sexually transmitted diseases. She had her last Pap smear 4 years ago and was within normal limits. She does not use tobacco, alcohol or illicit drugs. Pelvic examination shows no abnormalities. A repeat Pap smear now shows atypical squamous cells of undetermined significance (ASC-US). Which of the following is the most appropriate next step in management?
. Repeat Pap smear in 3 years
. Repeat Pap smear in 12 months
. Reflex HPV testing
. Immediate colposcopy
. Prescribe estrogen cream
362) A 27-year-old G2P1 woman comes to the labor and delivery unit with nausea, vomiting, and right lower-quadrant pain. She is at 19 weeks gestation. The symptoms started 12 hours ago and have become progressively worse. She has no chills, dysuria, or urinary frequency and is uncertain if she has had a fever. Her temperature is 38 C (100.4 F), blood pressure is 120/70 mm Hg, pulse is 98/min, and respirations are 18/min. Abdominal examination shows a gravid uterus just below the umbilicus. The fetal heart rate is 144/min. There is moderate tenderness to palpation in the right lower quadrant with guarding. Laboratory results are as follows: Hemoglobin: 12.4 g/L, Leukocytes: 16,000/μL. Which of the following is the most appropriate next step in management of this patient?
. Computed tomography of the abdomen
. Diagnostic laparoscopy
. Flat plate of the abdomen
. Magnetic resonance imaging
. Ultrasound of the abdomen
362) A 27-year-old G2P1 woman comes to the labor and delivery unit with nausea, vomiting, and right lower-quadrant pain. She is at 19 weeks gestation. The symptoms started 12 hours ago and have become progressively worse. She has no chills, dysuria, or urinary frequency and is uncertain if she has had a fever. Her temperature is 38 C (100.4 F), blood pressure is 120/70 mm Hg, pulse is 98/min, and respirations are 18/min. Abdominal examination shows a gravid uterus just below the umbilicus. The fetal heart rate is 144/min. There is moderate tenderness to palpation in the right lower quadrant with guarding. Laboratory results are as follows: Hemoglobin: 12.4 g/L, Leukocytes: 16,000/μL. Which of the following is the most appropriate next step in management of this patient?
. Computed tomography of the abdomen
. Diagnostic laparoscopy
. Flat plate of the abdomen
. Magnetic resonance imaging
. Ultrasound of the abdomen
363) A 27-year-old G3P2002, who is 34 weeks gestational age, calls the oncall obstetrician on a Saturday night at 10:00 PM complaining of decreased fetal movement. She says that yesterday her baby has moved only once per hour. For the past 6 hours she has felt no movement. She is healthy, has had regular prenatal care, and denies any complications so far during the pregnancy. Which of the following is the best advice for the on-call physician to give the patient?
. Instruct the patient to go to labor and delivery for a contraction stress test
. Reassure the patient that one fetal movement per hour is within normal limits and she does not need to worry
. Recommend the patient be admitted to the hospital for delivery
. Counsel the patient that the baby is probably sleeping and that she should continue to monitor fetal kicks. If she continues to experience less than five kicks per hour by morning, she should call you back for further instructions
. Instruct the patient to go to labor and delivery for a nonstress test
363) A 27-year-old G3P2002, who is 34 weeks gestational age, calls the oncall obstetrician on a Saturday night at 10:00 PM complaining of decreased fetal movement. She says that yesterday her baby has moved only once per hour. For the past 6 hours she has felt no movement. She is healthy, has had regular prenatal care, and denies any complications so far during the pregnancy. Which of the following is the best advice for the on-call physician to give the patient?
. Instruct the patient to go to labor and delivery for a contraction stress test
. Reassure the patient that one fetal movement per hour is within normal limits and she does not need to worry
. Recommend the patient be admitted to the hospital for delivery
. Counsel the patient that the baby is probably sleeping and that she should continue to monitor fetal kicks. If she continues to experience less than five kicks per hour by morning, she should call you back for further instructions
. Instruct the patient to go to labor and delivery for a nonstress test
367) A 27-year-old man is brought to his primary care physician by his wife because he has not been himself for the past ten days. His wife says that her formerly reserved, quiet husband has been staying up all night lately gambling their savings away while playing poker with friends that he recently met. He is also not concerned about having missed work for the past week. When asked about this recent change in behavior, the man smiles and replies proudly that he no longer needs to work because he has invested a large sum of money in a company that will soon make him rich. He speaks very quickly and it is difficult for him to focus his attention at times. Which one of the following medications would be most appropriate in the treatment of this patient?
Bupropion
. Clomipramine
. Clozapine
. Haloperidol
. Valproic acid
367) A 27-year-old man is brought to his primary care physician by his wife because he has not been himself for the past ten days. His wife says that her formerly reserved, quiet husband has been staying up all night lately gambling their savings away while playing poker with friends that he recently met. He is also not concerned about having missed work for the past week. When asked about this recent change in behavior, the man smiles and replies proudly that he no longer needs to work because he has invested a large sum of money in a company that will soon make him rich. He speaks very quickly and it is difficult for him to focus his attention at times. Which one of the following medications would be most appropriate in the treatment of this patient?
Bupropion
. Clomipramine
. Clozapine
. Haloperidol
. Valproic acid
392) A 28-year-old man is brought to the ER for a severe head injury after a fall. He was intubated in the field for his decreased level of consciousness. He is tachycardic and hypotensive. On examination, he is noted to have an obvious skull fracture and his right pupil is dilated. Which of the following is the most appropriate method for initially reducing his intracranial pressure?
. Elevation of the head of the bed
. Saline-furosemide (Lasix) infusion
. Mannitol infusion
. Intravenous dexamethasone (Decadron)
. Hyperventilation
392) A 28-year-old man is brought to the ER for a severe head injury after a fall. He was intubated in the field for his decreased level of consciousness. He is tachycardic and hypotensive. On examination, he is noted to have an obvious skull fracture and his right pupil is dilated. Which of the following is the most appropriate method for initially reducing his intracranial pressure?
. Elevation of the head of the bed
. Saline-furosemide (Lasix) infusion
. Mannitol infusion
. Intravenous dexamethasone (Decadron)
. Hyperventilation
393) A 28-year-old man with a past history of bilateral orchiopexy for cryptorchidism presents with a painless, unilateral right scrotal enlargement. On examination, there is a palpable right testicular mass and enlarged inguinal node. Scrotal ultrasonography demonstrates heterogeneity of the testis, with an associated hydrocele. A CT scan of the abdomen and pelvis demonstrated right-sided retroperitoneal adenopathy. CT scan of the chest is normal. Staging workup and surgery reveal a seminoma of the testicle, with positive inguinal and retroperitoneal nodes. Therapeutic management for this patient is which of the following?
. External beam radiotherapy
. Multidrug combination chemotherapy
. Combination radiotherapy and multidrug chemotherapy
. Clinical surveillance
. Laparotomy with pelvic and retroperitoneal node dissection
393) A 28-year-old man with a past history of bilateral orchiopexy for cryptorchidism presents with a painless, unilateral right scrotal enlargement. On examination, there is a palpable right testicular mass and enlarged inguinal node. Scrotal ultrasonography demonstrates heterogeneity of the testis, with an associated hydrocele. A CT scan of the abdomen and pelvis demonstrated right-sided retroperitoneal adenopathy. CT scan of the chest is normal. Staging workup and surgery reveal a seminoma of the testicle, with positive inguinal and retroperitoneal nodes. Therapeutic management for this patient is which of the following?
. External beam radiotherapy
. Multidrug combination chemotherapy
. Combination radiotherapy and multidrug chemotherapy
. Clinical surveillance
. Laparotomy with pelvic and retroperitoneal node dissection
399) A 28-year-old woman comes to the physician's office at 30 weeks gestation because she has not felt her baby's movements for the past week. Fetal heart tones are not heard by Doppler. An ultrasound shows an absence of fetal cardiac activity. Fetal demise is diagnosed. She underwent a cesarean section for her previous delivery to avoid a post-term pregnancy. She has no other medical problems. Vital signs are normal and physical examination shows no abnormalities. Her cervix is 3 cm dilated and 70 percent effaced. Laboratory studies show a platelet count of 230,000/mm and a fibrinogen level of 480 mg/dl (normal: 150-450mg/dl). Both the patient and her husband are shocked after hearing the news of fetal demise. Which of the following is the most appropriate next step in management?
. Rush the parents to have immediate induction of labor
. Admit the patient to the hospital and request psychiatry counseling
. Recommend cesarean section as soon as possible
. Discuss need for delivery and review options of vaginal versus cesarean
. Reassurance
399) A 28-year-old woman comes to the physician's office at 30 weeks gestation because she has not felt her baby's movements for the past week. Fetal heart tones are not heard by Doppler. An ultrasound shows an absence of fetal cardiac activity. Fetal demise is diagnosed. She underwent a cesarean section for her previous delivery to avoid a post-term pregnancy. She has no other medical problems. Vital signs are normal and physical examination shows no abnormalities. Her cervix is 3 cm dilated and 70 percent effaced. Laboratory studies show a platelet count of 230,000/mm and a fibrinogen level of 480 mg/dl (normal: 150-450mg/dl). Both the patient and her husband are shocked after hearing the news of fetal demise. Which of the following is the most appropriate next step in management?
. Rush the parents to have immediate induction of labor
. Admit the patient to the hospital and request psychiatry counseling
. Recommend cesarean section as soon as possible
. Discuss need for delivery and review options of vaginal versus cesarean
. Reassurance
400) A 28-year-old woman is brought to the emergency department by her sister after she experiences a generalized tonicclonic seizure. The patient appears confused and is unable to answer any questions. The sister says the patient has never had a seizure before. The patient's medical history is unremarkable except for a long history of panic disorder for which she has been taking high doses of "some medication." The sister adds that the patient missed a few doses recently because they were staying at a friend's house, but she is sure that the patient was otherwise regular in taking her medication. Which of the following medications was the patient most likely taking?
. Clonazepam
. Clomipramine
. Buspirone
. Alprazolam
. Paroxetine
400) A 28-year-old woman is brought to the emergency department by her sister after she experiences a generalized tonicclonic seizure. The patient appears confused and is unable to answer any questions. The sister says the patient has never had a seizure before. The patient's medical history is unremarkable except for a long history of panic disorder for which she has been taking high doses of "some medication." The sister adds that the patient missed a few doses recently because they were staying at a friend's house, but she is sure that the patient was otherwise regular in taking her medication. Which of the following medications was the patient most likely taking?
. Clonazepam
. Clomipramine
. Buspirone
. Alprazolam
. Paroxetine
404) A 28-year-old woman presents to the office for her routine Pap smear. She has had eight lifetime partners but has recently gotten married. For the past 5 years, she has only been sexually active with her husband. All of her previous Pap smear results have been normal. She denies any history of STIs. She has never been pregnant, although she would like to become pregnant soon. She denies any vaginal discharge, abnormal vaginal bleeding, or dyspareunia. VS: BP, 120/80 mm Hg; P, 83 beats/min; R, 15 breaths/min; T, 98.3°F. Review: Entire ROS is negative. Physical examination: Pelvic examination was done. Pap smear completed. No cervical discharge, no cervical, Lesions present. Bimanual Exam: No cervical motion tenderness, no adnexal enlargement or tenderness, no uterine enlargement. What is the next step in the management of this patient?
. Discuss birth control options
. Gonorrhea and Chlamydia screening
. Start folic acid supplementation
. Nothing to do
. Reassurance
406) A 28-year-old woman with sickle cell anemia presents to the urgent care clinic complaining of 12 hours of right upper quadrant pain. She has had similar pain previously, usually after eating fatty foods. However, past episodes have always resolved within one to two hours. On examination, her temperature is 38.3C and she has right upper quadrant pain with a positive Murphy's sign. Abdominal ultrasound reveals gallstones, a thickened gallbladder wall, and a normal common bile duct. Her alkaline phosphatase level is normal. What is the most appropriate next step in the management of this patient?
. Conservative management and elective cholecystectomy
. Endoscopic retrograde cholangiography
. Emergent cholecystectomy
. HIDA scan
. Percutaneous transhepatic drainage
411) A 29-year-old African-American woman comes to the physician after discovering a mass on breast self-examination. Her last menstrual period was 2 weeks ago. She reports occasional bilateral gray nipple discharge that has not changed since menarche. She has no significant past medical history and does not take any medications. Examination reveals a 1.5-cm fluctuant mass in the upper and outer quadrant of the left breast. Which of the following is the best next step in management?
Cytological examination of the nipple discharge
Fine-needle aspiration
Incisional biopsy
Mammography
Reassurance and continued breast self-examination
415) A 29-year-old G1P0 patient at 24 weeks gestational age presents to your office complaining of some shortness of breath that is more intense with exertion. She has no significant past medical history and is not on any medication. The patient denies any chest pain. She is concerned because she has always been very athletic and cannot maintain the same degree of exercise that she was accustomed to prior to becoming pregnant. On physical examination, her pulse is 72 beats per minute. Her blood pressure is 90/50 mm Hg. Cardiac examination is normal. The lungs are clear to auscultation and percussion. Which of the following is the most appropriate next step to pursue in the workup of this patient?
Refer the patient for a ventilation-perfusion scan to rule out a pulmonary embolism
. Perform an arterial blood gas
. Refer the patient to a cardiologist
. Reassure the patient
. Order an ECG
417) A 29-year-old G1P0 with an intrauterine pregnancy (IUP) at 37 weeks' gestation presents to the office for a routine prenatal visit. The patient states that she has a headache since this morning. She has no past medical history, no past surgical history, is taking no medications, and has no allergies. She denies visual disturbance, epigastric pain, nausea, and vomiting. Vital sign: BP, 150/90 mm Hg; P, 90 beats/min; R, beats/min; R, 16 breaths/min; T, 98.3°F (37.2 C). Fetal movement: Present. Contractions: Absent. Leakage of fluid: Absent. Vaginal bleeding: Absent. What is the next step in the management of this patient?
. Betamethasone
. Nonstress test
. Labetalol
. Urinalysis (UA)
. Magnesium sulfate
427) A 29-year-old woman complains of dysphagia with both solids and liquids, worse when she is eating quickly or is anxious. Manometry reveals normal basal esophageal sphincter pressure, with no relaxation of the sphincter on swallowing. Which of the following is the most appropriate next step in management?
. beta-blocker therapy
. Partial esophagectomy
. Anticholinergic drugs
. Calcium channel blockers
. Dietary modification
429) A 29-year-old woman has a long history of mild asthma. She now has a flare and experiences recurrent episodes of bronchial obstruction, fever, malaise, and expectoration of brownish mucous plug. On examination, there is bilateral wheezing. Infection is suspected and a CXR reveals upper lobe pulmonary infiltrates. The eosinophil count is 2000/mL, and serum precipitating antibodies to Aspergillus are positive. Which of the following is the most appropriate next step in management?
Antihelminthic therapy
A short course of systemic glucocorticoid therapy
Desensitization treatment
High-dose glucocorticoids by puffer
Long-term systemic glucocorticoid therapy
436) A 29-year-old woman, gravida 2, para 1, at 33 weeks’ gestation is referred to your office because of a possible herpes outbreak. She developed a painful vesicular rash a few days ago in her genital area. She has never before had any similar symptoms. She has no other medical problems, takes no medications, and has no known drug allergies. Examination reveals numerous erythematous vesicles and ulcerations. Testing of the lesion demonstrates herpes simplex virus infection and serologic testing reveals that it is a primary outbreak for the patient. Which of the following is the most appropriate management of this patient?
. Expectant management
. Immediate cesarean delivery
. Immediate induction of labor
. Intravenous acyclovir
. Oral acyclovir
468) A 30-year-old G2 P1 woman at 38 weeks gestation comes to the hospital because of regular and painful uterine contractions that started two hours ago. Pelvic examination reveals bulging membranes, and her cervix is 50% effaced and dilated to 3 cm. Her pregnancy was complicated by first trimester hemorrhage of unknown cause. Her past medical history is unremarkable. Upon observing the fetal heart rate monitor and an external tocometer for 20 minutes, you note 6 contractions. You also note 4 separate 15 - 20 beat/min decreases in the fetal heart rate with every contraction. The depth and duration of decelerations vary with successive uterine contractions. Which of the following is the most appropriate next step in the management of this patient?
. Oxygen administration and change in maternal position
. Artificial rupture of membranes
. Amnioinfusion
. Fetal scalp pH testing
. Emergent cesarean section
470) A 30-year-old G3P2 woman at 25 weeks’ gestation has a history of gestational diabetes in her previous pregnancy. Her fasting blood glucose level at her initial 10-week screening visit was 110 mg/dL and urinalysis was negative for glucose in the urine. The patient has not been taking her own blood sugars at home, but she has been adhering to a low-carbohydrate diet. Over the past several weeks, she has noticed increased fatigue and polyuria. Which of the following is the next most appropriate step?
Administer a 3-hour glucose tolerance test
Administer a 50-g 1-hour glucose tolerance test
Begin insulin therapy
Check a urinalysis and start insulin if urinalysis reveals glucose in the urine
Prescribe metformin to be taken daily
473) A 30-year-old male has recently been diagnosed with HIV infection. He denies drug abuse. He is currently asymptomatic, and physical examination is unremarkable. He is in a stable heterosexual relationship. Laboratory studies show a CD4 count of 350/microL, HIV viral load of 15,000 copies/mL, negative VDRL, negative toxoplasma serology, tuberculin skin test of 7 mm induration, negative HBsAg, and positive anti-HBsAg antibodies. Hepatitis C antibodies are negative. Complete blood count, serum chemistries, and liver function tests are within normal limits. He has not received any vaccinations since being diagnosed with HIV. Which of the following vaccines is indicated in this patient?
. BCG vaccine
. Hepatitis A vaccine
. Hepatitis B vaccine
. Pneumococcal vaccine
. Meningococcal vaccine
496) A 31-year-old African-American woman is diagnosed with uterine fibroids. Which of the following types of fibroids is most likely to interfere with conception and pregnancy?
Intracavitary
Intramural
Pedunculated
Submucosal
Subserosal
506) A 31-year-old woman smashes her car against a bridge abutment. She sustains multiple injuries, including upper and lower extremity fractures. She is fully awake and alert, and she reports that she was not wearing a seat belt and distinctly remembers hitting her abdomen against the steering wheel. Her blood pressure is 135/75 mm Hg, and her pulse is 88/min. Physical examination shows that she has a rigid, tender abdomen, with guarding and rebound in all four quadrants. She has no bowel sounds. Which of the following would be the most appropriate step in evaluating potential intra-abdominal injuries?
. Continued clinical observation
. CT scan of the abdomen
. Sonogram of the abdomen
. Diagnostic peritoneal lavage
. Exploratory laparotomy
514) A 32-year-old Caucasian male is admitted to the hospital due to a 1-week history of progressive paralysis of his upper and lower extremities. He had a flu-like illness 3 weeks ago, followed by paresthesias in his fingertips and toes. The weakness initially started in his lower extremities. He denies any changes in bowel and bladder functions. His blood pressure (supine) is 130/70mm Hg, heart rate is 82/min, respirations are 18/min, and temperature is 36.9°C (98.5°F). Physical examination reveals bilateral facial paralysis, orthostatic hypotension, areflexia in all four extremities, and distal paresthesias. His CSF analysis shows: Total WBC 10/cmm, Protein 120 mg/dl, Glucose 70 mg/dl, Gram stains No organisms. What is the most appropriate next step in the management of this patient?
. Intravenous methyl prednisolone
. Intravenous immunoglobulin therapy
. Intravenous acyclovir therapy
. Botulinum antitoxin
. Intravenous ceftriaxone and ampicillin
522) A 32-year-old G3P2 woman at 35 weeks’ gestation has a past medical history significant for hypertension. She was well-controlled on hydrochlorothiazide and lisinopril as an outpatient, but these drugs were discontinued when she found out that she was pregnant. Her blood pressure has been relatively well controlled in the 120–130 mm Hg systolic range without medication, and urinalysis has consistently been negative for proteinuria at each of her prenatal visits. She presents now to the obstetric clinic with a blood pressure of 142/84 mmHg. A 24hour urine specimen yields 0.35 g of proteinuria. Which of the following is the most appropriate next step?
Administer oral furosemide
Prepare for emergent delivery
Restart the patient’s prepregnancy antihypertensive regimen
Restricted activity and close monitoring as an outpatient following initial inpatient evaluation
Start hydralazine
525) A 32-year-old generally healthy woman presents to the office for a routine preemployment physical. She uses a vaginal ring for birth control. Her LMP was 2 weeks ago. She has been pregnant three times and has had two full-term births via normal spontaneous vaginal delivery. She had one spontaneous miscarriage at 10 weeks' gestation. She is only sexually active with her husband. She has a family history of breast cancer in her mother. Her mother had breast cancer at age 40 years and again at age 56 years. Her aunt also had breast cancer at an early age. Her last Pap smear, including human papillomavirus (HPV) was negative last year. BP, 120/80 mm Hg; P, 75 beats/min; R, 14 breaths/min; T, 98.4°F. Physical examination: Gen: Awake, alert, oriented x3, CVS: S1S2+ RRR no m/r/g, Lungs: Clear to auscultation bilaterally, Breast: No breast mass felt. What should be done as a part of the evaluation?
. Gonorrhea screening
. Chlamydia screening
. BRCA gene testing
. Mammography
. Pap-smear
541) A 32-year-old woman in the 2nd month of pregnancy is found to have a 5-cm mass in the upper outer quadrant of her left breast. Mammogram shows no other lesions, and core biopsy reveals infiltrating ductal carcinoma. Which of the following would be the best course of action at this time?
. Chemotherapy now, deferring surgery until after delivery
. Radiation therapy now, deferring surgery until after delivery
. Lumpectomy and axillary sampling, followed in 6 weeks by radiotherapy
. Modified radical mastectomy now, deferring systemic therapy until later
. Immediate therapeutic abortion and palliative breast surgery
551) A 32-year-old woman, gravida 1, para 0, with a history of infertility, underwent ovulation induction resulting in a twin pregnancy, now at 31 weeks’ gestation. An early obstetric sonogram at 7 weeks’ gestation showed dichorionic placentation. She has a positive group B –hemolytic streptococcus vaginal culture. Because of epigastric pain, vaginal bleeding, and uterine contractions, she is evaluated at the maternity unit. An obstetric sonogram shows twin A to be a female fetus in breech presentation and twin B to be a male fetus in transverse lie with the back down. The sonogram also shows a marginal anterior placenta previa. Her initial vital signs are as follows: temperature, 37.2C (99.0F); pulse, 95/min; respiration, 18/min; blood pressure, 165/115 mm Hg. Her urine dipstick test shows 2 glucose and 3 albumin. Which of the following is a contraindication to tocolysis in this case?
Multiple gestation
Marginal placenta previa
Severe preeclampsia
Early gestational age
Positive group B -hemolytic streptococcus vaginal culture
555) A 32-year-old woman, gravida 3, para 2, at 30 weeks gestation comes to the hospital because of new onset painful, regular uterine contractions that began 5 hours ago. Her pregnancy has been uncomplicated. Her second pregnancy was complicated by preterm labor at 28 weeks gestation. She has no discharge, leakage of fluid or bleeding from the vagina; she has no dysuria or urgency. Her temperature is 37.0C (98.7F), blood pressure is 125/70 mmHg, pulse is 80/min and respirations are 18/min. Pelvic examination shows a soft, partially effaced and posterior cervix dilated to 2cm. A Nitrazine test is negative. Nonstress test shows a reassuring fetal heart pattern and uterine contractions occurring every 7 minutes. Which of the following is the most appropriate next step in management?
. Tocolysis
. Amnioinfusion
. Reassure and discharge home
. Augment delivery
. Cervical cerclage
559) A 32-year-old, gravida 3, para 2 woman at 35 weeks gestation comes to the hospital because of regular and painful uterine contractions occurring every 5 - 6 minutes. She also has continuous leakage of clear fluid from her vagina that started 10 hours earlier. She has chronic hypertension and was prescribed methyldopa throughout pregnancy but has been noncompliant. She also has a history of drug abuse and has missed two previous antenatal appointments. Her temperature is 37.0C (98.7F), blood pressure is 160/100 mmHg, pulse is 80/min and respirations are 16/min. Sterile speculum examination shows pooling of amniotic fluid in the vagina; the cervix is 80% effaced and 3cm dilated. Ultrasound shows a small for gestational age fetus in the vertex presentation with a decreased amniotic fluid index. Fetal heart monitoring shows repetitive late decelerations. Uterine contractions are now occurring every 4 minutes. Which of the following is the most appropriate next step in management?
. Augmentation of labor
. Tocolysis
. Cesarean section
. Betamethasone IM
. Expectant management
564) A 33-year-old G1P1 woman presents to her gynecologist for a Pap smear. It has been several years since she last saw a physician. She is not currently sexually active, but takes oral contraceptives. Her vaginal examination is normal, but her Pap smear shows moderate-grade cervical intraepithelial neoplasia. The patient undergoes colposcopy and biopsies, which confirm the diagnosis. What is the most appropriate management of this patient?
Continued annual Pap smears
Loop electrosurgical excision procedure
Radiation therapy
Serial colposcopies every 3–4 months
Total abdominal hysterectomy
580) A 34-year-old G1P0 woman at 29 weeks’ gestation presents to the emergency department complaining of 2 hours of vaginal bleeding. The bleeding recently stopped, but she was diagnosed earlier with placenta previa by ultrasound. She denies any abdominal pain, cramping, or contractions associated with the bleeding. Her temperature is 36.8C (98.2F), blood pressure is 118/72 mm Hg, pulse is 75/min, and respiratory rate is 13/min. She reports she is Rh positive, her hemoglobin is 11.1 g/dL, and coagulation tests, fibrinogen, and D-dimer levels are all normal. On examination her gravid abdomen is non-tender. Fetal heart monitoring is reassuring, with a heart rate of 155/min, variable accelerations, and no decelerations. Two large-bore peripheral intravenous lines are inserted and two units of blood are typed and crossed. What is the most appropriate next step in management?
Admit to the antenatal unit for bed rest and betamethasone
Admit to the antenatal unit for bed rest and blood transfusion
Admit to the antenatal unit for bed rest and treatment with RhO(D) immune globulin
Emergent cesarean section
Outpatient expectant management
584) A 34-year-old G2P1001 with an IUP at 38 weeks' gestation presents to labor and delivery for contractions. The patient states that she has had gestational diabetes that was diet controlled throughout her pregnancy. She states that she has had routine prenatal care. Vital sign: BP, 125/88 mm Hg; P, 95 beats/min; R, 12 breaths/min; T, 98.6°F. Contractions: Present, Fetal movement: Present. Physical examination: Gen: Awake, alert, oriented x3, mild pain distress, CVS: S1S2+ RRR no m/r/g, Vaginal bleeding: Absent, Leakage offluid: Present, Lungs: CTA bilaterally, Abd: Gravid, contractions present, Ext: 1+ edema bilaterally. Cervical Examination: 7 cm, 100% effaced, -1 station. Fetal Heart Monitoring: Reassuring, good variability, accelerations are present, no decelerations. What is the next step in the management of this patient?
. Complete blood count (CBC)
. Finger stick
. HgbAlC
. Administer insulin drip
. Administer Ampicillin
599) A 34-year-old unrestrained male driver is brought to the ER after a motor vehicle accident. His cervical spine is immobilized. He is stuporous. At the scene of the accident, his blood pressure is 70/30 mm Hg and heart rate is 130/min. Lungs are clear to auscultation. Abdominal wall ecchymosis is present. Abdomen is mildly distended. Bowel sounds are decreased. Neck veins are collapsed. After two liters of intravenous fluids, his blood pressure is 80/40 mmHg. A focused assessment with sonography for trauma shows blood in the peritoneal cavity but no obvious solid organ injury. Which of the following is the most appropriate next step in management?
Laparoscopy
. Laparotomy
. X-ray films of the abdomen and pelvis
. CT scan of the abdomen
. Diagnostic peritoneal lavage
607) A 34-year-old woman presents to the physician's office for infertility evaluation. Her cycles have been irregular for the past 12 months and she hasn't had any periods for the past 3 months. Previously, her cycles were quite regular. She also has hot flashes, dyspareunia and mood disturbances. She has been married for 6 years and has a three-year-old daughter. She has a history of Hashimoto thyroiditis and is on thyroid replacement therapy. She smokes one pack of cigarettes daily. Vital signs are normal. Pelvic examination reveals atrophic vaginal mucosa. Serum FSH is markedly elevated, and serum prolactin is normal. Serum TSH is within normal limits. Which of the following is the most appropriate treatment for her infertility?
. Clomiphene citrate
. Metformin
. GnRH agonist
. Progesterone supplement
. In vitro fertilization
608) A 34-year-old woman presents to your office complaining of several months of chest pain. She says that the pain is left-sided, does not change with deep inspiration, and typically lasts several hours. The pain has no relation to physical activity, but worsens with emotional stress. The patient has no significant family history, and does not use tobacco, alcohol or drugs. She takes no medications and has no drug allergies. On exam, her blood pressure is 110/70 mmHg and her heart rate is 78/min. ECG is normal. Which of the following is the best next step in her management?
Reassurance
Stress ECG testing
Transthoracic echocardiography
Lower extremity venous ultrasonography
Chest X-ray
612) A 34-year-old woman, gravida 3, para 2, at 38 weeks gestation presents to the labor and delivery ward complaining of headache. She has no contractions. Her prenatal course was unremarkable until she noted the onset of swelling in her face, hands, and feet this week. Her obstetric history is significant for two normal spontaneous vaginal deliveries. She has no significant past medical or surgical history. Her temperature is 37 C (98.6 F), blood pressure is 160/92 mm Hg, pulse is 78/min, and respirations are 16/min. Examination reveals 3+ patellar reflexes bilaterally. A cervical examination reveals that her cervix is 3 cm dilated and 50% effaced and soft, and that the fetus is at 0 station and vertex. The fetal heart rate has a baseline of 140/min and is reactive. The results from a 24-hour urine collection show 5200 mg of protein (normal < 300 mg/24 hours). The patient is given magnesium sulfate intravenously for seizure prophylaxis. Which of the following is the most appropriate next step in the management of this patient?
Expectant management
Intramuscular glucocorticoids
IV oxytocin
Subcutaneous terbutaline
Cesarean section
613) A 34-year-old woman, gravida 4, para 3, at 32 weeks gestation is brought to the emergency department because of vaginal bleeding. Her prenatal course, prenatal tests and fetal growth have been normal. Prenatal ultrasound at the 12th week showed an intrauterine gestation consistent with dates. Her temperature is 37.0C (98.7 F), blood pressure is 90/70 mm of Hg, pulse is 98/min and respirations are 18/min. Physical examination shows continuous bright red vaginal bleeding. Ultrasonogram in the emergency department shows complete placenta previa. Fetal heart tracing shows repetitive late decelerations. The patient's vital signs are stabilized with fluids, but the bleeding continues. Which of the following is the most appropriate next step in management?
. Immediate induction of labor
. Emergency cesarean section
. Administer corticosteroids and perform elective surgery later
. Forceps delivery
. Continue expectant management until the bleeding stops
622) A 35-year-old G3P3 with a Pap smear showing high-grade squamous intraepithelial lesion of the cervix (CIN III) has an inadequate colposcopy. Cone biopsy of the cervix shows squamous cell cancer that has invaded only 1 mm beyond the basement membrane. There are no confluent tongues of tumor, and there is no evidence of lymphatic or vascular invasion. The margins of the cone biopsy specimen are free of disease. The patient above now asks you for your advice on how to treat her cervical disease. Your best recommendation is for the patient to undergo which of the following?
. Treatment with external beam radiation
. Implantation of radioactive cesium into the cervical canal
. Simple hysterectomy
. Simple hysterectomy with pelvic lymphadenectomy
. Radical hysterectomy
623) A 35-year-old G3P3 woman has been experiencing bilateral breast pain for the past year. Breast examination and mammography are normal. Conservative measures have failed. Which of the following medications is most likely to bring relief?
Clomiphene
Tamoxifen
Danazol
Hydrochlorothiazide
Medroxyprogesterone
627) A 35-year-old homeless man presents to the emergency department with chief complaints of a cough and fever. He is intoxicated. He admits to drinking about a fifth of vodka every day and confirms a history of delirium tremens and blackouts. X-ray of the chest is significant for an air-fluid level in the superior segment of the right lower lobe. Which of the following is the most appropriate first-line agent for treating this patient’s condition?
Azithromycin
Clindamycin
Isoniazid
Moxifloxacin
Piperacillin-tazobactam
658) A 35-year-old woman, gravida 3, para 2, at 39 weeks' gestation, comes to the labor and delivery ward with contractions. Past obstetric history is significant for two normal spontaneous vaginal deliveries at term. Examination shows the cervix to be 4 centimeters dilated and 50% effaced. The patient is contracting every 4 minutes. Over the next 2 hours the patient progresses to 5-centimeters dilation. An epidural is placed. Artificial rupture of membranes is performed, demonstrating copious clear fluid. 2 hours later the patient is still at 5centimeters dilation and the contractions have spaced out to every 10 minutes. Which of the following is the most appropriate next step in management?
. Expectant management
. Intravenous oxytocin
. Cesarean delivery
. Forceps-assisted vaginal delivery
. Vacuum-assisted vaginal delivery
663) A 36-year-old G1P0 woman pregnant with twins presents to her obstetrician for her routine 32-week appointment. She has gained 5.4kg (12-lb) in the past 2 weeks. When questioned about her weight gain, she states she has had headaches and some blurred vision for the past 2 weeks, which she thinks is secondary to dehydration. To circumvent this, she has been drinking a lot of water, which she claims “is making me swell, even my hands.” She also has had some epigastric pain for the past 2 weeks, which she attributes to “all the water I’ve been drinking.” Her blood pressure is 142/90 mm Hg, pulse is 105/min, and respiratory rate is 18/min. Urinalysis reveals 1+ glycosuria and 4+ proteinuria. Which of the following is the best next step in management?
Administer magnesium sulfate only
Administer oral antihypertensive therapy
Expectant management
Induce labor
Platelet transfusion
664) A 36-year-old G1P1 comes to see you for a routine postpartum examination 6 weeks after an uncomplicated vaginal delivery. She is currently nursing her baby without any major problems and wants to continue to do so for at least 9 months. She is ready to resume sexual activity and wants to know what her options are for birth control. She does not have any medical problems. She is a nonsmoker and is not taking any medications except for her prenatal vitamins. Which of the following methods may decrease her milk supply?
. Intrauterine device
. Progestin only pill
. Depo-Provera
. Combination oral contraceptives
. Foam and condoms
687) A 37-year-old woman comes to the physician's office because of left breast discomfort. The discomfort has been there for several months, and she recently started having breast pain before menses. Yesterday she noticed a lump in her breast. She has no family history of breast cancer. She smokes one pack of cigarettes every day. She had a baseline mammogram at age 35, which showed no abnormalities. Examination shows a smooth, soft, mobile mass palpable in the upper outer quadrant of the left breast; some diffuse nodularity is present bilaterally. Vital signs are normal. Physical examination otherwise shows no abnormalities. Fine needle aspiration of the mass shows thin greenish, non-bloody fluid; the mass disappears completely after the aspiration. Which of the following is the most appropriate next step in management?
. Recommend mammogram to be done as soon as possible
. Prescribe oral contraceptives and reassure her
. Reassure and reexamine her in six weeks
. Send the aspirated fluid for cytologic analysis
. Recommend ultrasound evaluation of the aspirated cyst
692) A 38-year-old female comes to your office with a recent episode of hemoptysis. The symptoms started one week ago with malaise, throat pain and dry cough. The cough progressed becoming productive of yellowish sputum. She started noticing speckles of red blood in her sputum as of yesterday. Her past medical history is significant for peptic ulcer disease. She has a 5 pack-year smoking history, but she quit 10 years ago. Her temperature is 98°F (36.7°C), blood pressure is 130/80 mmHg and heart rate is 87/min. Physical examination reveals scattered bilateral wheezes. Chest X-ray shows clear lung fields. Which of the following is the most appropriate next step in management?
. CT scan of the chest
. Pulmonary function tests
. Sputum Gram stain and culture
. Observation
. Sputum cytology
696) A 38-year-old male with a chronic history of schizophrenia is admitted to the hospital for deterioration in his condition. He is a known patient and was stable on risperidone for the past few years. Today, the patient does not respond when spoken to and he sits motionlessly. He makes no eye contact and his face remains expressionless. Vital signs include temperature of 37.0°C (98.6°F), blood pressure of 132/80 mm Hg, pulse of 88/min, and respirations of 14/min. Physical examination demonstrates diffuse muscle rigidity but is otherwise unremarkable. Which of the following would be the most appropriate next step?
. Increase risperidone dose
. Initiate therapy with dantrolene sodium
. Replace risperidone with quetiapine
. Continue same dose of risperidone and add clozapine
. Administer lorazepam
722) A 39-year-old woman, gravida 3, para 2, at 39 weeks’ gestation comes to the labor and delivery ward with regular contractions and gush of fluid 1 hour ago. On examination she is found to have rupture of membranes and is 4 cm dilated. She is admitted to labor and delivery. Her prenatal course was significant for a 36-week vaginal culture that was positive for Group B Streptococcus (GBS) that is sensitive to clindamycin. She also has gestational diabetes that is treated with diet. She has no other medical problems and has never had surgery. She takes no medications and is allergic to penicillin. After she is admitted to the labor and delivery ward, a penicillin infusion is erroneously started. Soon thereafter, the patient develops generalized pruritus and urticaria with angioedema and difficulty breathing. Which of the following is the most appropriate next step in the management of this patient?
. Administer diphenhydramine
. Administer epinephrine
. Administer magnesium sulfate
. Intubate the patient
. Stop the penicillin infusion
737) A 4-year-old girl with sickle cell disease presents to the emergency department with a temperature of 39.6 C (103.2 F). Other than irritability, the physical examination is unremarkable. Laboratory evaluations reveal a white blood cell count of 18,200/mm3, with 88% polymorphonuclear neutrophils, 10% lymphocytes, and 2% monocytes, and a hemoglobin of 7.6 g/dL. Which of the following is the most appropriate next step in management?
. Observe the child pending blood culture results
. Administer amoxicillin orally
. Administer ceftazidime and gentamicin intravenously
. Administer ceftriaxone intravenously
. Administer vancomycin and gentamicin intravenously
766) A 42-year-old male is brought to the emergency department immediately after having a prolonged seizure episode. His family describes a past medical history of grand mal seizures. He has been on phenytoin for the past 10 years, but stopped taking the drug six months ago because he had not had any seizures in the last nine years. He is otherwise healthy and had been doing well until this seizure episode. He does not use tobacco, alcohol or drugs. He is afebrile. His blood pressure is 136/88 mm Hg, respirations are 18/min and pulse is 96/min. He appears confused and lethargic. Chest auscultation is unremarkable, and his abdomen is soft and nontender. A limited neurologic examination is non-focal. His laboratory report shows: Serum sodium 140 mEq/L, Serum potassium 4.0 mEq/L, Chloride 103 mEq/L, Bicarbonate 17 mEq/L, Blood urea nitrogen (BUN) 20 mg/dl, Serum creatinine 0.8 mg/dl, Blood glucose 98 mg/dl. Chest x-ray and urinalysis are within normal limits, and a CT scan of the head is unremarkable. Which of the following is the most appropriate next step in the management of this patient's metabolic acidosis?
. Give intravenous bicarbonate
. Check serum ketones
. Check serum lipase
. Observe and repeat the labs after 2 hours
. Start dopamine
762) A 42-year-old African-American woman presents to your office with bilateral knee pain that severely limits her mobility. She also complains of joint stiffness in the morning that takes several hours to improve. Her hand joints are symmetrically swollen. She has been taking over-the-counter ibuprofen and aspirin with little relief of symptoms. She has no other medical problems and does not use tobacco, alcohol, or illicit drugs. Her vital signs are within normal limits. Physical examination shows pain and swelling of both wrists and knees. Laboratory studies reveal: Hemoglobin 8.4 mg/dl, Serum iron 30 μg/dL (normal 50-150 μg/dL), Total iron binding capacity 230 μg/dL (normal 300-360 μg/dL), Ferritin 300 ng/dl. Which of the following is most likely to improve this patient's anemia?
. Iron supplementation
. Folic acid supplementation
. Cyanocobalamin supplementation
. Infliximab
. Splenectomy
767) A 42-year-old man comes to the physician because of a 3-month history of burning substernal chest pain after every meal. His other medical problems include chronic alcoholism. Upper endoscopy shows mucosal irregularity and ulceration of the squamocolumnar junction above the lower esophageal sphincter. Multiple biopsies are taken. He complains of worsening substernal pain radiating to the back, left chest pain, and mild shortness of breath 4 hours later. His temperature is 37.1°C (98.9°F), blood pressure is 110/70 mm Hg, pulse is 120/min, and respirations are 34/min. A chest x-ray shows a small left pleural effusion that was not present on a chest radiograph taken 2 weeks ago. Which of the following is the most appropriate next step in management?
. Repeat the endoscopy
. Order water-soluble contrast esophagram
. Check serum amylase and lipase levels
. Wait until the pathologic diagnosis is ready
. Perform thoracocentesis
787) A 43-year-old Caucasian man with a two-year history of diabetes mellitus presents to your office for a routine. He has no complaint His medications are metformin and aspirin. He works as a computer programmer and has a sedentary lifestyle. He drinks one to two cans of beer on weekends and smokes one pack of cigarettes per day. On physical examination, his blood pressure is 153/94 mmHg and his heat rate is 82/min. His BMI is 32.5 kg/m2. The remainder of the physical examination is unremarkable. Laboratory studies reveal an HbA1c of 7.6%. At his check-up one month ago, his blood pressure was 149/92 mmHg. Which of the following interventions would be most effective for controlling his blood pressure?
. Aerobic exercise
. Weight loss
. Smoking cessation
. Better diabetes control
. Quitting alcohol
817) A 45-year-old man is brought to the emergency department after being involved in an automobile crash. He is alert and oriented, with a normal neurologic examination. His respiratory rate is 20/min, with clear lungs, pulse rate of 120/min, and blood pressure of 80/40 mmHg. On examination, he is noted to have a distended abdomen, with decreased bowel sounds, and a fracture of the right ankle. IV access is established, and the patient receives a rapid infusion of 2 L of saline, without changes to pulse rate or blood pressure. Which of the following is the most appropriate next step in his management?
. abdominal CT scan
. Insertion of a Swan-Ganz catheter
. Exploratory laparotomy
. Focused abdominal sonography for trauma (FAST)
. Diagnostic peritoneal lavage
821) A 45-year-old man presents to the physician’s office for evaluation of a skin lesion on his abdomen. He states that the lesion has been present for 1 year, but has recently enlarged over the last 2 months. The mass is nontender, and he is otherwise asymptomatic. Past history is unremarkable. Examination reveals a 3-cm, pigmented, irregular skin lesion located in the left lower quadrant of the abdomen, as shown in Figure 6-12. Heart, lung, and abdominal examination are normal. There are no palpable cervical, axillary, or inguinal lymph nodes. Chest x-ray and liver function tests are normal. Which of the following is the most appropriate next step in management?
 
A
. Wide excision with 2 cm margin
. Wide excision with 2 cm margin and SLN mapping
. Shave biopsy
. Excisional biopsy with 1–2 mm margins
. Mohs’ surgical excision
826) A 45-year-old man with advanced chronic renal failure comes to the physician because of edema of his feet. His temperature is 37°C (99°F), blood pressure is 150/100mm Hg, pulse is 78/min, and respirations are 15/min. Examination shows bilateral ankle edema. Laboratory studies show BUN of 62 mg/dl, serum creatinine of4.2 mg/dl, serum potassium of 5.6 meq/l, serum sodium of 146 meq/l, and total plasma cholesterol of 260 mg/dl. Which of the following is most likely to improve the prognosis of his disease?
. Captopril
. Simvastatin
. Protein restriction
. Salt restriction
. Potassium restriction
828) A 45-year-old man with known cirrhosis due to hepatitis C is admitted to the hospital for abdominal discomfort and confusion. Physical examination reveals a distended abdomen, leg edema, and deep yellow discoloration of the skin and sclerae. Bibasilar crackles are heard on chest auscultation. His serum sodium level is 127 mEq/L, potassium level is 2.9 mEq/L, and creatinine level is 1.3 mg/dl. On day 3 of his hospitalization, the serum creatinine is 4.2mg/dl. A urinalysis reveals: Protein negative, Glucose negative, WBC 4-5/hpf, RBC 0-1/hpf. Renal ultrasound is normal and the post-void residual urinary volume is less than 50 ml. He is given 2 L of normal saline intravenously with no change in his serum creatinine concentration. This patient's kidney dysfunction can be best corrected by which of the following?
. High-dose spironolactone
. ACE inhibitors
. Liver transplantation
. Broad spectrum antibiotics
. Pegylated interferon
833) A 45-year-old woman is undergoing chemotherapy for breast cancer. She presents 10 days after her last chemotherapy with fever (temperature > 38.5°C), but no other symptoms except a sore throat and mouth. On examination, she looks well, there is oral mucositis, ears are normal, lungs are clear, and the central line site is clean. The CXR, urinalysis, and biochemistry are normal. Her WBC is 800/mL and the absolute neutrophil count is low ( < 500). Which of the following is the most appropriate next step in management?
Start empiric bacterial antibiotics
Start empiric antifungal and bacterial antibiotics
Acetaminophen alone until culture results are available
Start antiviral medications for HSV-1
Start antiviral and bacterial antibiotics
842) A 45-year-old woman with no PMH presents to the office for an increase in abdominal fullness and bloating, worsening over the past 3 or 4 months. The patient states that she feels nauseous all the time, although has not had any vomiting. She states because of the constant nausea, she has not been eating as much. She has had a 10-lb weight loss in the last 4 months. BP, 110/70 mm Hg; P, 97; R, 18; T, 98.6°F. ROS: Denies fever and chills, Weight loss has occurred (10 lb in 4 months), Denies chest pain, shortness of breath, and abdominal pain, Nausea is present with no vomiting, No diarrhea or constipation. PE: Gen: Awake, alert, oriented x3, Abd: Soft, nontender, distended bowel sounds are present, shifting dullness to percussion is present, Pelvic: Cervix normal, no cervical motion tenderness, right adnexal enlargement is present. Which of the following is the next step in the management of this patient?
. Abdominal US
. BHCG
. Hepatitis panel
. Pelvic US
. CA-125
849) A 46-year-old male was admitted with epigastric pain radiating to the back. He has a previous history of endocarditis from intravenous drug use and cellulitis of the arm. Serum lipase is elevated. He was admitted and treated conservatively. Two days later he started to have a fever. He is awake but slightly disoriented. His temperature is 38.7C (101.6F), blood pressure is 120/76 mm Hg, pulse is 110/min and respirations are 16/min. He is tremulous and says bugs are crawling on him. His blood cultures are positive for gram negative rods. Empiric antibiotic therapy is started. CT scan of the abdomen shows a new 6 x 6 cm cystic lesion attached to the pancreatic head. Laboratory results show: Hematocrit 44.0 g/L, MCV 105fl, Leukocyte count 18,500/mm3, Amylase 255 U/L. Which of the following is the most appropriate next step in management?
External drainage of the cystic lesion
Continue conservative management
. Obtain echocardiogram to evaluate for endocarditis
. Obtain Ca 19-9 level for pancreatic cancer
. Perform lumbar puncture to rule out meningitis
852) A 46-year-old woman presents to your office complaining of something bulging from her vagina for the past year. It has been getting progressively more prominent. She has started to notice that she leaks urine with laughing and sneezing. She still has periods regularly every 26 days. She is married. Her husband had a vasectomy for contraception. After appropriate evaluation, you diagnose a second-degree cystocele. She has no uterine prolapse or rectocele. Which of the following is the best treatment plan to offer this patient?
. Anticholinergic medications
. Antibiotic therapy with Bactrim
. Le Fort colpocleisis
. Surgical correction with a bladder neck suspension procedure
. Use of vaginal estrogen cream
859) A 47-year-old diabetic woman comes to the physician due to the recent onset of tremors. She has undergone combined pancreatic and kidney transplantation secondary to end stage renal disease and diabetes. She takes multiple medications, including immunosuppressants. Her temperature is 36.1° C (97°F), blood pressure is 152/90 mm Hg, pulse is 78/min, and respirations are 16/min. Examination shows gum hypertrophy. Laboratory studies show: Hb 13.0 g/dl, WBC 8,000/cmm, Serum Na 135 mEq/L, Serum K 5.3 mEq/L, BUN 26 mg/dl, Serum Creatinine 1.7 mg/dl. Which of the following immunosuppressants is most likely responsible for her presentation?
. Tacrolimus
. Cyclosporine
. Azathioprine
. Mycophenolate
. Diuretic
860) A 47-year-old male who has just returned from a cruise to the Bahamas presents to the hospital with a high-grade fever, productive cough and shortness of breath for the past two days. He also complains of frequent vomiting and diarrhea. He has no prior medical problems, does not take any medications, and denies using tobacco, alcohol or drugs. His temperature is 40°C (104°F), blood pressure is 110/65 mm Hg, pulse is 80/min, and respirations are 18/min. Lung examination reveals right lower lobe crackles. The abdomen is soft and non-tender. Chest x-ray demonstrates right lower lobe consolidation. Sputum Gram stain contains many neutrophils with no organisms. Which of the following antibiotics must be given to this patient?
. Vancomycin
. Clindamycin
. Fluconazole
. Amoxicillin
. Azithromycin
866) A 48-year-old Caucasian female is undergoing a routine work-up 9 months after radical mastectomy due to right-sided breast cancer. She has no present complaints, and says that she is 'full of energy'. Chest radiograph reveals an isolated pulmonary nodule, 2.0 cm in diameter, in the middle lobe of the right lung. CT confirms that the lesion is solitary with poorly defined margins, but completely within lung parenchyma. Bone scan is negative. CT abdomen and pelvis is normal. Transthoracic biopsy demonstrates adenocarcinoma with positive estrogen receptors (ER) and no HER-2/neu overexpression. Which of the following is the best management strategy for this patient?
. Surgery
. Systemic chemotherapy
. Hormone therapy
. Pretreatment with monoclonal antibodies against HER-2/neu
. Combined chemotherapy and endocrine therapy
873) A 48-year-old woman presents to her gynecologist because of vaginal bleeding. She states that after a year of hot flashes and irregular cycles, she finally stopped menstruating 4 months ago. Two days ago she began having some vaginal bleeding that was very similar to her prior menses. She is concerned because she heard that the first sign of endometrial cancer in postmenopausal women is vaginal bleeding. She is an otherwise healthy woman with no medical problems. She exercises three times a week and takes multivitamins. She had three children when she was 29–35 years old. She used oral contraceptive pills for contraception from the time she was 18 until she got married at the age of 28. Which of the following is the most appropriate next step in managing this woman’s vaginal bleeding?
Abdominal ultrasound
Endometrial biopsy
Follow-up examination in 6 months
Measure serum level of follicle-stimulating hormone
Prescription of testosterone cream
874) A 49-year-old man presents to the clinic for a health maintenance visit. He has a family history of type 2 DM. His medical history is significant for gastroesophageal reflux disease, for which he takes omeprazole and over-the-counter antacids. He smokes one pack of cigarettes per day and drinks an average of two beers per night. The patient’s body mass index is 32 kg/m². Which of the following most greatly reduce(s) the patient’s risk of future coronary artery disease, renal failure, and retinopathy?
Alcohol avoidance
Daily multivitamin
Diet rich in fruit and vegetables
Smoking cessation
Weight loss and exercise
915) A 51-year-old man presenting to the clinic for routine examination mentions that he has not been able to get over the flu. Further questioning clarifies that he has had a nonproductive cough for the past 3–4 months and is unable to sustain his normal walking pace for prolonged periods. He reports feeling more fatigued than he recalls feeling last year. His medical history is significant for hypertension, alcoholism, and obesity. His blood pressure is well controlled on losartan and hydrochlorothiazide. He has no known drug allergies. His mother died of complications of type 2 diabetes mellitus. His father had a fatal myocardial infarction at age 56 years. The patient smokes half a pack of cigarettes per day and has done so for the past 7 years. He has worked all his adult life as an accountant and has no known exposures to asbestos or organic dusts. His blood pressure is 134/96 mm Hg, heart rate is 78/min, respiratory rate is 16/min, temperature is 37°C (98.6°F), and oxygen saturation is 94% on room air. Lung examination reveals bilateral inspiratory crackles in the lung bases. High-resolution CT shows patchy areas of ground glass, reticular abnormalities, and traction bronchiectasis. Laboratory findings are normal except for an elevated erythrocyte sedimentation rate of 54 mm/hr. What is the recommended treatment for this patient’s cough?
Change the antihypertensive agent
Prescribe amantadine
Prescribe bronchodilators and long-term domiciliary oxygen therapy
Prescribe glucocorticoids
Resect diseased lung fields
922) A 52-year-old man develops sudden-onset shortness of breath on postoperative day 4 after a hemicolectomy for colon cancer. His surgery went well with no operative complications. He reports no cough, sputum, or pleuritic chest pain. His blood pressure is 155/90 mm Hg, pulse 100/min, temperature 37.8°C, lungs are clear, and heart sounds normal. He has bilateral pedal edema, but no discomfort in his legs. His CXR and ECG are normal. A chest CT with contrast reveals a thrombus in his right upper lobe artery. Which of the following statements concerning the management of this condition is most likely correct?
Continuous IV heparin or subcutaneous low-molecular-weight heparin (LMWH) therapy is indicated
Urgent thrombolytic therapy is indicated
Urgent inferior vena cava (IVC)
Filter insertion is indicated
Confirmation of the diagnosis with bilateral ultrasound leg Dopplers
927) A 52-year-old nurse seeks medical retirement because of a "heart condition." She complains of disabling attacks of tachycardia and palpitations. The physical examination and ECG studies confirm that indeed her pulse is between 100 and 105/min at all times, and she is in and out of atrial fibrillation. It is also noted that she is fidgety and constantly moving, and various examiners remark that she arrives for tests lightly dressed when it is rather cold outside. Thyroid function studies show elevated free thyroxine (T4) and undetectable levels of thyroid stimulating hormone (TSH). Her thyroid gland is not clinically enlarged or tender. Which of the following is the most appropriate next step in diagnosis?
. Fine needle aspiration cytology of the thyroid gland
. MRI of the pituitary area
. Radioactive iodine uptake
. Serum levels of C peptide
. Serum levels of tri-iodo-thyronine (T3)
933) A 52-year-old woman undergoes a sigmoid resection with primary anastomosis for recurrent diverticulitis. She returns to the emergency room 10 days later with left flank pain and decreased urine output; laboratory examination is significant for a white blood cell (WBC) count of 20,000/mm3. She undergoes a CT scan that demonstrates new left hydronephrosis, but no evidence of an intra-abdominal abscess. Which of the following is the most appropriate next step in management?
. Intravenous pyelogram
. Intravenous antibiotics and repeat CT in 1 week
. Administration of intravenous methylene blue
. No further management if urinalysis is negative for hematuria
. Immediate reexploration
949) A 54-year-old male with a past medical history of type 2 diabetes mellitus comes to the emergency department complaining of shortness of breath. His blood pressure is 146/92 mmHg, respiratory rate is 26/min, and oxygen saturation is 87% on room air. Cardiac auscultation over the apex shown S3. Based on the physical findings, which of the following is the best initial therapy for this patient?
. Inhaled bronchodilators
. Intravenous beta-blockers
. Intravenous diltiazem
. Intravenous diuretics
. Pericardiocentesis
962) A 55-day-old infant born prematurely at 27 weeks of gestation is shown below. The swelling is not tender, firm, hot, or red, and it does not transil luminate. It seems to resolve with pressure, but returns when the infant cries or strains. Which of the following is the most appropriate course of action at this point?
 
 
A
. Obtain a surgical consultation
. Perform a needle aspiration
. Order a barium enema
. Order a KUB (plain radiographs of kidney, ureter, and bladder)
. Observe the patient and reassure the patient and family
965) A 55-year-old Caucasian male presents to your office for a routine check-up. His past medical history is significant for gout, hypertension, and hypercholesterolemia. His current medications include enalapril and pravastatin. He does not smoke or consume alcohol. His blood pressure is 156/94 mmHg and heart rate is 80/min. Physical examination reveals that the patient is moderately overweight (BMI = 27 kg/m2) with increased waist-to-hip ratio. You consider adding hydrochlorothiazide to the treatment regimen to improve the control of hypertension. Which of the following metabolic effects do you expect to emerge after this correction?
. Hypocalcemia
. Hyperkalemia
. Decreased LDL cholesterol
. Decreased plasma triglycerides
. Hyperglycemia
970) A 55-year-old male with a history of rheumatoid arthritis and rheumatoid lung disease is admitted to the hospital with palpitations. His restrictive lung disease is of moderate severity, requiring use of 2 liters of oxygen by nasal cannula at all times. He has no known history of coronary artery disease, hypertension or diabetes. On physical examination, his blood pressure is 110/70 mmHg and heart rate is 120 and irregular. EKG shows atrial fibrillation with a rapid ventricular rate. Which of the following medications should be avoided in this patient?
. Verapamil
. Digoxin
. Quinidine
. Amiodarone
. Metoprolol
990) A 55-year-old woman is brought to the emergency department by fi re and rescue personnel because of intractable back and thigh pain for the past 3 hours. Upon presentation she says that the pain is 9 of 10 in severity and localized to her lower back. She lives with her sister, and she has no primary care physician. She denies any complaints aside from fatigue, which she attributes to her multiple jobs and caring for her sister’s children. She has a pulse of 110/min, blood pressure of 140/88 mm Hg, respiratory rate of 20/min, and temperature of 37.8C (100.1F). On physical examination she is exquisitely tender over the L2–3 area of the spine. She also has point tenderness over the anterior right thigh. Sensation is intact over the lower extremities bilaterally and she has 5/5 strength in the lower extremities bilaterally. Breast examination reveals a retracted nipple and dimpling of the right breast. What will likely represent the mainstay of treatment for this patient’s symptoms?
Bone marrow transplant
Chemotherapy
Hormone replacement therapy
Radiation therapy
Surgery
995) A 55-year-old-woman presents to the physician’s office for evaluation of mammographic findings on a screening mammogram. She denies any breast masses, nipple discharge, pain, or skin changes. Past history is pertinent for insulindependent diabetes. Family history is positive for postmenopausal breast cancer in her mother. She has a normal breast examination and no axillary adenopathy. A mediolateral oblique (MLO) view of the right breast is shown. Which of the following is the most appropriate next step in management?
 
A
. observation, with repeat mammogram in 6–12 months
. ultrasound
. biopsy
. lumpectomy, radiation therapy, and sentinel lymph node (SLN) biopsy
. Total mastectomy
997) A 56-year-old male is admitted to the ICU for the management of hepatic encephalopathy. He is a known alcoholic. He is started on oral neomycin, lactulose, and a low-protein, high-carbohydrate diet. His blood pressure is 116/78 mm Hg, pulse is 78/min, temperature is 37.5°C (99.5°F), and respirations are 18/min. His labs reveal the following: Hb 10.2 g/dl, WBC 7,400/cmm, Hct 27%, Platelets 4 2,000/mm3, PT 18 sec, INR 2.02, PTT 31 sec. He has no evidence of active bleeding. Which of the following should be administered to this patient at this time?
. Fresh frozen plasma
. Cryoprecipitate
. Vitamin K
. Platelets
. Packed RBC
1020) A 57-year-old previously alcoholic man with a history of chronic pancreatitis presents with hematemesis. Endoscopy reveals isolated gastric varices in the absence of esophageal varices. His liver function tests are normal and he has no stigmata of end-stage liver disease. Ultrasound examination demonstrates normal portal flow but a thrombosed splenic vein. He undergoes banding, which is initially successful, but he subsequently rebleeds during the same hospitalization. Attempts tocontrol the bleeding endoscopically are unsuccessful. Which of the following is the most appropriate next step in management?
. Transjugular intrahepatic portosystemic shunt
. Surgical portocaval shunt
. Surgical mesocaval shunt
. Splenectomy
. Placement of a Sengstaken-Blakemore tube
1036) A 58-year-old woman is seen for evaluation of a swelling in her right vulva. She has also noted pain in this area when walking and during coitus. At the time of pelvic examination, a mildly tender, fluctuant mass is noted just outside the introitus in the right vulva in the region of the Bartholin gland. Which of the following is the most appropriate treatment?
. Marsupialization
. Administration of antibiotics
. Surgical excision
. Incision and drainage
. Observation
1047) A 59-year-old patient with a 2-year history of metastatic breast cancer presents with the acute onset of severe low back pain. She underwent a radical mastectomy and lymphadenectomy 3 years ago. Four of seven nodes were positive at the time of her original diagnosis. One year ago she developed an asymptomatic metastasis to her right femur. On physical examination, she is in severe discomfort and finds movement extremely difficult. She has exquisite tenderness in the lumbar vertebral area, and any motion of her legs or lower back produces extreme pain. An emergent MRI reveals large lytic lesions in L3 and L4. Which of the following is the most appropriate next step in management?
Discuss her wishes regarding cardiopulmonary resuscitation (CPR)
Refer her to a pain management consultant
Prescribe bed rest with high-dose nonsteroidal anti-inflammatory drugs (NSAIDs)
Schedule her for radiation therapy to the lumbar spine
Schedule her for an emergency nuclear bone scan
1048) A 59-year-old white male comes to the office for the evaluation of a brief episode of right arm and leg weakness. The episode lasted for a few minutes, and was followed by a complete recovery. He had a similar episode one month ago. He has a 30 pack-year history of cigarette smoking. He has hypercholesterolemia, which is being treated with diet and exercise. His pulse is 76/min, regular, and blood pressure is 130/80 mmHg. His laboratory test results are: Hb 14.2 g/dl, WBC 7,000/cmm, Platelets 230,000/cmm, Blood Glucose 118 mg/dl, Serum Na 138 mEq/L, Serum K 4.5 mEq/L, BUN 16 mg/dl, Serum Creatinine 1.0 mg/dl. EKG shows normal sinus rhythm. CT scan of the head is unremarkable. MRI angiography of the head and neck fails to show any abnormality. Transesophageal echocardiography (TEE) is unremarkable. Which of the following is the most appropriate next step in management?
. Treatment with aspirin
. Treatment with heparin followed by warfarin
. Treatment with clopidogrel
. Treatment with combination of aspirin and dipyridamole
. Treatment with ticlopidine
1051) A 59-year-old woman undergoes an exploratory laparotomy for peritonitis and is found to have perforated diverticulitis. She undergoes a sigmoid resection with an end colostomy. She is administered a third-generation cephalosporin within 1 hour prior to the incision and the antibiotic is continued postoperatively. One week later, she develops an intra-abdominal abscess, which is percutaneously drained. Bacteroides fragilis is isolated from the cultures. Which of the following statements regarding her perioperative antibiotic regimen is most accurate?
. The preoperative dose of antibiotics should have been given closer to the time of incision.
. The patient should have received several doses of antibiotics prior to laparotomy.
. The patient should have received a first-generation cephalosporin.
. The patient did not have adequate gram-negative coverage.
. The patient did not have adequate anaerobic coverage.
1063) A 6-year-old girl presents with a 2-day history of cough and fever. At your office she has a temperature of 39.4°C (103°F), a respiratory rate of 45 breaths per minute, and decreased breath sounds on the left side. Her chest x-ray is shown below. Which of the following is the most appropriate initial treatment?
 
A
N-acetylcysteine chest physiotherapy
Vancomycin
Partial lobectomy
Postural drainage
Placement of tuberculosis skin test
1072) A 60-year-old female presents with transient loss of consciousness. She appears lethargic and confused. She also complains of hemoptysis and weight loss of 10 lbs (4.5kg) over a period of 2 months. She has smoked one pack of cigarettes daily for the last 40 years. Her temperature is 37.0°C (98.6°F), pulse is 75/min, blood pressure is 110/70 mmHg, and respirations are 16/min. Her mucus membranes are moist. There is no jugular venous distention. Her neurological examination is non-focal, and cardiovascular examination is unrevealing. There is no ankle edema or ascites. Serum studies show: Sodium 115 mEq/L, Potassium 3.7 mEq/L, Bicarbonate 22 mEq/L, Blood glucose 100 mg/dL, BUN 10.0 mg/dL. Serum osmolality is 250 mOsm/Kg, and urine osmolality is 500 mOsm/Kg. Urine sodium concentration is 40 mEq/L. Chest x-ray shows a mass in the right hilar region. What is the most appropriate next step in the management of this patient?
. Normal saline
. Loop diuretics
. Water restriction
. Hypertonic saline
. Demeclocycline
1075) A 60-year-old male patient is receiving aspirin, an angiotensin-converting enzyme inhibitor, nitrates, and a beta-blocker for chronic stable angina. He presents to the ER with an episode of more severe and long-lasting angina chest pain each day over the past 3 days. His ECG and cardiac enzymes are normal. Which of the following is the best course of action?
Admit the patient and add intravenous digoxin
Admit the patient and begin low-molecular-weight heparin
Admit the patient for thrombolytic therapy
Admit the patient for observation with no change in medication
Increase the doses of current medications and follow closely as an outpatient
1082) A 60-year-old man is admitted to the coronary care unit with a large anterior wall myocardial infarction. On his second hospital day, he begins to complain of the sudden onset of numbness in his right foot and an inability to move his right foot. On physical examination, the right femoral, popliteal, and pedal pulses are no longer palpable. The left lower extremity is normal. Which of the following is the most appropriate management of this patient?
. Duplex imaging of the right lower extremity arteries
. CT angiogram of the right lower extremity
. CT angiogram of bilateral lower extremities
. Embolectomy of the right femoral artery
. Embolectomy of the right femoral artery with exploration of the contralateral femoral artery
1085) A 60-year-old man is brought to the emergency department due to syncope. He has had similar episodes a few times during the past few weeks. These episodes usually occur after he exerts himself. He does not feel confused or tired after these episodes. He denies any chest pain or palpitation. His wife reports that when he collapses, he seems to lose consciousness for a few seconds, but then is back to being alert right away. She denies any jerking movement. His past medical history is significant diverticulosis, for which he takes fiber supplements. He is not on any other medication. His temperature is 37.1°C (98.8°F), blood pressure is 110/98 mm Hg, pulse is 88/min, and respirations are 14/min. On examination, he has a fourth heart sound and harsh 3/6 systolic murmur, best heard over the right sternal border. The murmur is accentuated on expiration. The lung fields are clear to auscultation. After performing an echocardiograph to confirm the diagnosis, which of the following management options is most appropriate?
. Aortic valvotomy
. Aortic valve replacement
. Close outpatient follow-up with serial echocardiograms
. Exercise test looking for arrhythmias
. Observe until the patient develops breathlessness
1102) A 62-year-old female is brought in by EMS due to a severe right-sided headache, nausea and eye pain. She was fixing a light bulb, when she suddenly felt pain in her right eye. She decided to rest, but the eye pain only got worse. In the next few minutes, she developed loss of vision, photophobia and redness in the same eye. She took medications to relieve the accompanying headache, but the eye pain persisted. She denies any trauma. Her past medical history is significant for diabetes and hypertension. She appears to be in intense pain with bouts of nausea. Her right eye is red, with conjunctival flushing and visual acuity of 20/200. Her right pupil is mid-dilated and non-reactive to light. The same eye feels hard on palpation. The one treatment that should be avoided in this patient is:
. Mannitol
. Acetazolamide
. Pilocarpine
. Timolol
. Atropine
1103) A 62-year-old female is hospitalized with epigastric pain and vomiting. Her past medical history includes mild COPD, congestive heart failure, diabetes mellitus and a stroke that occurred 2 years ago. Her current medications are insulin glargine and aspirin. Her blood pressure is 110/70 and her heart rate is 76/min. Comprehensive work-up is suggestive of acute calculous cholecystitis, and a cholecystectomy is planned. Which of the following would reduce postoperative mortality in this patient?
. Vancomycin
. Enalapril
. Metoprolol
. Verapamil
. Metformin
1104) A 62-year-old male is brought to the emergency department with a chief complaint of weakness. He says that he was walking his dog 1 hour ago when he began to limp and noticed some weakness in his left arm. His past medical history is significant for hypertension treated with hydrochlorothiazide, and type II diabetes mellitus managed with metformin. He denies nausea, vomiting, chest pain, fever or chills. He does note occasional palpitations and tension headaches at baseline. On physical examination, his blood pressure is 170/95 mmHg and his heart rate is 76/min and regular. His blood glucose level is 190 mg/dl and his HbA1c is 7.6%. The neurological examination is significant for profound left-sided weakness and an up going Babinski reflex on the left. Non-contrast head CT is negative for any intracranial bleed. Which of the following is most likely to affect his chance of neurological recovery?
. Insulin for tight glucose control
. Labetalol
. Aspirin
. Fibrinolytic
. Heparin
1113) A 62-year-old woman comes to the office for evaluation of a pigmented lesion on her left forearm. The lesion occasionally itches but is otherwise asymptomatic. She admits that she only came because her daughter had persuaded her to do so. On examination, there is a slightly elevated, brown-colored lesion measuring 7 mm in diameter with irregular borders. What is the best next step in management?
Shave biopsy
Excisional biopsy
Dermoscopy
Excision with 1 cm margins
Incisional biopsy
1123) A 63-year-old insurance agent is brought to the ED by paramedics for shortness of breath and an RR of 31 breaths per minute. The patient denies chest pain, fever, vomiting, or diarrhea. His wife says he ran out of his “water pill” 1 week ago. His BP is 185/90 mmHg, HR is 101 beats per minute, oxygen saturation is 90% on room air, and temperature is 98.9°F. There are crackles midway up both lung fields and 2+ pitting edema midway up his legs. An ECG shows sinus tachycardia. The patient is sitting up and able to speak to you. After placing the patient on a monitor and inserting an IV, which of the following is the most appropriate next step in management?
. Obtain blood cultures and complete blood cell (CBC) count, and begin empiric antibiotic therapy
. Order a statim (STAT) portable chest x-ray
. Administer oxygen via nasal cannula and have the patient chew an aspirin
. Administer oxygen via non-rebreather, furosemide, nitroglycerin, and consider non-invasive respiratory therapy
. Rapid sequence endotracheal intubation
1124) A 63-year-old male presents to the urgent care center with a four hour history of abdominal pain which he describes as severe, diffuse and constant. He has had one episode of non-bloody vomiting since the pain started. His past medical history is significant for coronary artery disease, diabetes, hypertension, chronic atrial fibrillation and chronic kidney disease. His current medications are lisinopril, digoxin, warfarin, metoprolol, and simvastatin and insulin glargine. On physical examination, his blood pressure is 130/70 mmHg and his heart rate is 100/min and irregular. Physical examination reveals an overweight male in moderate distress. His abdomen is diffusely tender to palpation with positive rebound tenderness. His laboratory findings are as follows: Hemoglobin 9.5 mg/dl, WBC count 7,500/mm3, Platelets 90,000/mm3, Sodium 137 mEq/L, Potassium4.5 mEq/L, Chloride 101 mEq/L, Bicarbonate 22 mEq/L, Glucose 210 mg/dl, Creatinine 1.8 mg/dl, INR 2.1, Blood digoxin level therapeutic. An upright abdominal x-ray shows free air under the diaphragm. Which of the following is the best initial treatment for this patient?
. Packed red blood cell transfusion
. Platelet transfusion
. Vitamin K
. Desmopressin
. Fresh frozen plasma
1129) A 63-year-old man with multiple rib fractures and a pulmonary contusion requires prolonged intubation. He is unable to be weaned from the ventilator and is on a volume control mode. He has a tracheostomy and a percutaneous gastrotomy in place through which he is being fed. The surgeon orders a respiratory quotient (RQ), which is the ratio of the rate of carbon dioxide production over the rate of oxygen uptake. The RQ is 1. Based on this information, which of the following is the next step in his management?
. Decrease the inspired concentration of oxygen
. Decrease the rate on the ventilator
. Increase the rate on the ventilator
. Decrease the carbohydrates in his enteral feeds
. Increase the total number of calories in his enteral feeds
1135) A 63-year-old woman is undergoing a total abdominal hysterectomy (TAH) for atypical endometrial hyperplasia. She mentioned to her doctor 2 weeks prior to the surgery that she has had problems with leakage of urine with straining and occasional episodes of urinary urgency. A urine culture at that visit is negative. She has had preoperative cystometrics done in the doctor’s office showing loss of urine during Valsalva maneuvers along with evidence of detrusor instability. The doctor has elected to do a retropubic bladder neck suspension following the TAH. A Marshall-Marchetti-Krantz procedure (MMK) is done to attach the bladder neck to the pubic symphysis. The patient does well after her surgery and is released from the hospital on postoperative day 3. Which of the following should her doctor advise her prior to her discharge?
. Urinary retention is very common after an MMK procedure and often requires long-term self-catheterization.
. She has a 5% risk of enterocele formation.
. The MMK procedure is highly effective, with greater than 90% long-term cure rate.
. Osteitis pubis occurs in approximately 10% of patients after an MMK, but is easily treated with oral antibiotics.
. She will not need any additional treatment for her bladder dysfunction.
1161) A 65-year-old lady comes to the office for the evaluation of her deteriorating memory. She has become increasingly forgetful over the last several months, and now appears very concerned about her memory loss. She used to pride herself for her sharp memory, but has been forgetting the most trivial things and has become "extremely inefficient." She also complains of easy fatigability, poor appetite, and frequent awakening at night. She feels worthless and has lost interest in her favorite hobby, which is gardening. On coughing or laughing, she loses urine involuntarily, and this is adding to her misery. She lives with her husband, who says that she has become very "cranky and irritable" lately. Her medical history is significant for hypercholesterolemia, for which she refuses to take medication. She is presently not on any hormonal therapy. The physical examination is completely normal. Laboratory studies are unremarkable. CT scan of the head is normal. What is the best next step in the management of this patient?
. Start hormonal replacement therapy
. Treat her with donepezil
. Start selective serotonin reuptake inhibitor
. Surgical bypass shunting
. Reassurance
1169) A 65-year-old man complains of blood in his urine for the past 2 months. He has had no similar episodes in the past. He is otherwise healthy and denies abdominal pain, any trauma, fever, chills, anorexia, or dysuria. He reports having a good urinary stream and no nocturia or dribbling. He is not sexually active. He has no other medical problems and is not taking any medications. His vital signs are stable. Lung, heart, abdominal, and groin examination are unremarkable. Rectal exam reveals a nontender prostate with no masses or enlargement- Urinalysis reveals packed red cells, a few white cells, and no casts. Which of the following is the most appropriate management?
Prescribe levofloxacin
Schedule a prostatic biopsy
Schedule a renal angiogram
Schedule a cystoscopy
Schedule a pelvic CT scan
1183) A 65-year-old woman is very worried because she recently had a close family member and friend die, one after the other. First, her 85-year-old mother died of an ovarian cancer that was diagnosed 3 years ago. Last week, she lost her best friend to lung cancer that metastasized to the liver and brain. Today, her 58-year-old sister learned that she has breast cancer. She has regular pap smears and breast examinations. She has read in the paper that there are a few ways that have proved to be very successful in preventing breast cancer. Which of the following measures has the best evidence of preventing breast cancer in high-risk women?
. Prophylactic oophorectomy
. BRCA screening
. Low-fat diet
. Tamoxifen
. Having mammograms every month
1200) A 67-year-old woman with a past medical history significant for hypertension, hypercholesterolemia, and type 2 diabetes calls 911 for severe shortness of breath. Her symptoms started 2 hours ago with chest pain and progressed rapidly to orthopnea and shortness of breath. Her blood pressure is 170/ 100 mmHg and heart rate is 120/min and regular. A third heart sound is present. Bilateral crackles are heard on chest auscultation. Her oxygen saturation is 78% with 40% inspired oxygen. She is intubated in the field by paramedics for progressive respiratory failure and is treated with nitrates and diuretics. After the initial resuscitation, breath sounds on the left side are markedly decreased. Which of the following is most likely to restore breath sounds to this hemithorax?
. Left-sided chest tube
. Left-sided needle thoracostomy
. Pericardiocentesis
. Endotracheal tube withdrawal
. Tidal volume increase
1210) A 68-year-old man presents to the emergency department complaining of left lower extremity pain. He says that he first noticed a tingling sensation in his leg 3 hours ago, and since that time it has become increasingly painful. Over the past hour, he says, the skin on his leg has started to change color. His medical history is significant for hypertension, diabetes mellitus, atrial fibrillation, and major depressive disorder. He cannot remember his medication list at this time. On physical examination, his blood pressure is 127/74 mmHg and his heart rate is 102/min. His left lower extremity is cool and pale below the level of the knee. Neither the posterior tibial nor the dorsalis pedis pulse is palpable. Which medication could have prevented this acute problem?
. Aspirin
. Metoprolol
. Clopidogrel
. Warfarin
. Diltiazem
1214) A 7 -day-old male infant is brought by his mother complaining of decreased movements of his right arm. She denies any trauma or fall. Pregnancy was uneventful, but delivery was complicated with shoulder dystocia. Examination reveals the presence of crepitus and bony irregularity over the clavicular area and Mora reflex is absent on the right. Which of the following is the most appropriate management?
Reassurance
Figure-of-eight clavicle strap
Passive and active motion exercises
Nerve grafting
Casting of the right arm and shoulder
1216) A 7 -year-old boy is brought to your office with a mild fever and neck swelling. His mother says that the boy has been complaining of neck pain for a couple of days and she noticed a tender neck lump yesterday. All of his vaccinations are up-to-date. He has no known allergies. Physical examination reveals a tender and fluctuant anterior cervical mass. Which of the following is the best medication for this patient?
. Penicillin
. Amoxicillin
. Dicloxacillin
. Erythromycin
. Acyclovir
1218) A 7-day-old female neonate is brought to your office for a 2-day history of jaundice and poor feeding. According to the mother, she has vomited twice but doesn't appear febrile. She is regularly breastfed. Her birth history is unremarkable. On examination, she appears listless, and mild jaundice, along with signs of dehydration, are noted. Her blood pressure is 78/52mm Hg, pulse rate is 150/min, and temperature is 36 C (96 F). Her family history is insignificant. What is the most appropriate next step in the management of this patient?
. Stop breast feeding
. Obtain blood cultures and lumbar puncture
. Obtain peripheral smear and reticulocyte count
. Obtain liver function tests
. Obtain Coomb's test and osmotic fragility test
1219) A 7-month-old boy is brought to his physician because of increased agitation and restlessness. Lung examination reveals crackles and decreased breath sounds bilaterally. Chest x-ray films are notable for bilateral pneumonia. Arterial blood gas analysis reveals an oxygen tension of 45 mm Hg and a carbon dioxide tension of 60 mm Hg. Which of the following is the most appropriate next step in management?
Obtain blood cultures
Administer oxygen
Administer bronchodilators
Administer antibiotics
Insert endotracheal tube
1245) A 71-year-old woman with a 40-year smoking history is noted to have a peripheral nodule in her left upper lobe on chest x-ray. Workup is consistent with small cell lung cancer with ipsilateral mediastinal lymph node involvement but no extrathoracic disease. What is the best treatment option for this patient?
. Thoracotomy with left upper lobectomy and mediastinal lymph node dissection
. Thoracotomy with left upper lobectomy and mediastinal lymph node dissection followed by adjuvant chemotherapy
. Neoadjuvant chemotherapy followed by thoracotomy with left upper lobectomy and mediastinal lymphnode dissection
. Neoadjuvant chemoradiation followed by thoracotomy with left upper lobectomy and mediastinal lymph-node dissection
. Chemoradiation
1242) A 70-year-old woman has nausea, vomiting, abdominal distention, and episodic crampy midabdominal pain. She has no history of previous surgery but has a long history of cholelithiasis for which she has refused surgery. Her abdominal radiograph reveals a spherical density in the right lower quadrant. Which of the following is the definitive treatment for this patient’s bowel obstruction?
. Ileocolectomy
. Cholecystectomy
. Ileotomy and extraction
. Nasogastric (NG) tube decompression
. Intravenous antibiotics
1246) A 72-year-old Caucasian male presents with shortness of breath that awakens him at night. At baseline he is able to walk less than a block before stopping to catch his breath. Physical examination findings include bilateral basilar rales and neck vein distention. The patient has a known history of congestive heart failure, and his last echocardiogram revealed an ejection fraction of 25%. The patient is compliant with a medication regimen including an ACE inhibitor, beta-blocker, and loop diuretic. Blood pressure is well controlled. What additional treatment should you begin next?
. Spironolactone
. Aspirin
. Amlodipine
. Warfarin
. Hydralazine and isosorbide dinitrate
1273) A 76-year-old male nursing home resident is hospitalized with confusion, fever and decreased oral intake. His past medical history is significant for type 2 diabetes mellitus, hypertension, osteoarthritis and gout. Blood cultures are positive for E coli. Despite antibiotic therapy, he slips into respiratory failure. He is intubated and placed on mechanical ventilation with an FiO2 of 70%, tidal volume of 500 ml and respiratory rate of 14/min. His current arterial blood gases are: pH 7.45, pO2 59 mmHg, pCO2 30 mmHg, HCO3 21 mEq/L. Which of the following is the best next step in managing this patient?
. Increase tidal volume
. Increase respiratory rate
. Increase the fraction of inspired oxygen
. Add positive end-expiratory pressure
. Decrease the fraction of inspired oxygen
1272) A 75-year-old woman with history of angina is admitted to the hospital for syncope. Examination of the patient reveals a systolic murmur best heard at the base of the heart that radiates into the carotid arteries. Electrocardiogram (ECG) is notable for left ventricular hypertrophy with evidence of left atrial enlargement. ECG reveals an aortic valve area of 0.7 cm2. What is the most appropriate next step in her management?
. Medical management with a nitrate and an angiotensin-converting enzyme inhibitor
. Bilateral carotid endarterectomies
. Percutaneous coronary artery angioplasty and stenting
. Coronary artery bypass surgery
. Aortic valve replacement
1287) A 9-year-old African-American boy is brought to ER with high fever, poor appetite, and irritability. His heart rate is 140/min and his blood pressure is 80/60 mmHg. He has been hospitalized several times before for poorly localized abdominal pain. He also has a history of hematuria. The boy has not received several routine vaccinations because his mother is afraid that they will cause autism. His hematocrit is 22% and the reticulocyte count is 12%. The patient dies file:///D:/DES_Entry_2016MCQs/3C_USMLE/C-4Management/4Manag... 271 several hours after the admission. This patient's death may have been prevented by which one?
. Biopsy of the vaginal ulceration
. Schedule abdominal sacral colpopexy
. Place a pessary
. Prescribe oral estrogen
. Prescribe topical vaginal estrogen cream
1280) A 79-year-old female presents to your office with a three-day history of nausea, diarrhea, poor oral intake and weakness. Her past medical history is significant for hypertension treated with enalapril and diltia zem. Her serum chemistry shows the following: Sodium 139 mEq/L, Potassium 7.8 mEq/L, Bicarbonate 14 mEq/L, Chloride 95 mEq/L, Glucose 155 mg/dl, BUN 80 mg/dl, Creatinine 3.1 mg/dl. EKG reveals QRS prolongation and prominent T wave peaking in precordial leads. Which of the following pharmacologic therapies plays a role in treating this patient's electrolyte condition?
. Stimulating alpha 1-adrenoreceptors
. Stimulating beta 1-adrenoreceptors
. Stimulating beta2-adrenoreceptors
. Blocking alpha 1-adrenoreceptors
. Blocking beta 1-adrenoreceptors
1286) A 9-month-old, chubby, healthy-appearing boy is brought to the pediatrician because of episodes of colicky abdominal pain and blood-tinged stools. The pain lasts from 1 to 10 minutes and causes the infant to double up; he then appears normal until his next bout of colic. During the examination, the infant has another episode, at which time a vague mass can be felt on the right side of the abdomen, and the right lower quadrant has an "empty" feeling to deep palpation. Which of the following is the most appropriate initial step in management?
Barium enema
Colonoscopy
Gastrografin enema
Upper gastrointestinal endoscopy
Exploratory surgery
1357) A patient with mild skin pigmentation is admitted emergently to your service because of sudden abdominal pain, fever, and a rigid abdomen. Her blood work indicates a marked leukocytosis, a blood sugar of 55 mg/dL, a sodium value of 119 mEq/dL, and a potassium value of 6.2 mEq/dL. Her blood pressure is 88/58-mmHg. She undergoes an exploratory laparotomy. Which of the following is the definitive treatment for her primary condition?
. 10% dextrose infusion
. Bicarbonate
. Hypertonic saline
. Corticosteroids
. Vasopressors
1359) A pedestrian is hit by a speeding car. Radiologic studies obtained in the emergency room, including a retrograde urethrogram (RUG), are consistent with a pelvic fracture with a rupture of the urethra superior to the urogenital diaphragm. Which of the following is the most appropriate next step in this patient’s management?
. Immediate percutaneous nephrostomy
. Immediate placement of a Foley catheter through the urethra into the bladder to align and stent the injured portions
. Immediate reconstruction of the ruptured urethra after initial stabilization of the patient
. Immediate exploration of the pelvis for control of hemorrhage from pelvic fracture and drainage of pelvic hematoma
. Immediate placement of a suprapubic cystostomy tube
1363) A pregnant woman is discovered to be an asymptomatic carrier of Neisseria gonorrhoeae. A year ago, she was treated with penicillin for a gonococcal infection and developed a severe allergic reaction. Which of the following is the treatment of choice at this time?
. Tetracycline
. Ampicillin
. Spectinomycin
. Chloramphenicol
. Penicillin
1366) A previously healthy 16-year-old girl presents to the emergency center with the complaint of “falling out.” She was with her friends at a local fast food restaurant when she felt faint and, according to her friends, lost consciousness for about a minute. There was no seizure activity noted, but the friends did notice her arms twitching irregularly. She is now acting normally. She denies chest pain or palpitations, and her electrocardiogram (ECG) is normal. Further management of this patient should include which of the following?
. Obtain an EEG
. Refer to a child psychiatrist
. Begin β-blocker therapy
. Encourage adequate fluid and salt intake
. Obtain serum and urine drug screens
1373) A previously healthy 4-year-old girl is brought to the office due to a 12-day history of persistent, thick, nasal discharge, nasal congestion, headache, cough, and intermittent low-grade fever. The cough is worse at night, but there is no wheezing. Her temperature is 37.2C (99F), pulse is 90/min, and respirations are 15/min. Examination shows an alert, interactive child breathing comfortably. She has clear tympanic membranes, congested posterior nasal pharynx with thick and purulent mucus, and red, swollen nasal turbinates. Her maxillary sinuses are mildly tender. Her lungs are clear on auscultation. What is the most appropriate next step in the management of this patient?
X-ray paranasal sinuses
CT scan of sinuses
Sinus aspiration
Start the patient on decongestants
Start the patient on oral amoxicillin
1384) A stockbroker in his mid-40s presents with complaints of episodes of severe, often incapacitating chest pain on swallowing. Diagnostic studies on the esophagus yield the following results: endoscopic examination and biopsy mild inflammation distally; manometry—prolonged high-amplitude contractions from the arch of the aorta distally, lower esophageal sphincter (LES) pressure 20 mm Hg with relaxation on swallowing; barium swallow 2 cm epiphrenic diverticulum. Which of the following is the best management option for this patient?
. Myotomy along the length of the manometric abnormality
. Diverticulectomy, myotomy from the level of the aortic arch to the fundus, fundoplication
. Diverticulectomy, cardiomyotomy of the distal 3 cm of esophagus and proximal 2 cm of stomach with antireflux fundoplication
. A trial of calcium-channel blockers
. Pneumatic dilatation of the LES
1394) A woman is found to have a unilateral invasive vulvar carcinoma that is 2 cm in diameter but not associated with evidence of lymph node spread. Initial management should consist of which of the following?
. Chemotherapy
. Radiation therapy
. Simple vulvectomy
. Radical vulvectomy
. Radical vulvectomy and bilateral inguinal lymphadenectomy
1398) A young man is shot with a .45 caliber revolver, point blank in the lower abdomen, just above the pubis. The entrance wound is at the midline, and there is no exit wound. X-ray films show the bullet embedded in the sacral promontory, to the right of the midline. Digital rectal examination and proctoscopic examination are negative, but he has gross hematuria. He is hemodynamically stable. Which of the following is the most appropriate next step in management?
. CT scan of the abdomen
. Intravenous pyelogram
. Retrograde cystogram
. Diagnostic peritoneal lavage
. Exploratory laparotomy
1401) A young motorcycle driver is thrown against a concrete bridge abutment and sustains severe trauma about the face, with marked periorbital edema and ecchymosis as well as epistaxis. He is obtunded with rapid, shallow breathing. Which of the following is the next appropriate step in his workup and management?
. Evaluation of the cervical spine.
. Blind nasopharyngeal intubation with cervical in-line stabilization.
. Oropharyngeal intubation with cervical in-line stabilization.
. Emergency tracheostomy.
. Emergency cricothyroidotomy.
1402) A23-year-old woman with no PMH presents to the office for her annual gynecologic examination. She has never been pregnant. She has had five lifetime partners. She does not have vaginal discharge, vaginal pruritus, or dyspareunia. Her menstruation is regular every 28 days and lasts for 5 days. BP, 125/75 mm Hg; P, 78 beats/min; R, 16 breaths/min; T, 98.4°F. In addition to the Pap smear, what else is indicated?
. Chlamydia testing
. Hepatitis testing
. Herpes testing
. Trichomonas testing
. HIV testing
1411) An 11-year-old boy presents with fever and sore throat. A rapid-strep test confirms streptococcal pharyngitis. He is leaving for a summer camp in 2 days. In the past, he has had problem finishing the whole course of antibiotic treatment. Which of the following is the best treatment for his streptococcal pharyngitis?
. A single dose of benzathine penicillin G intramuscularly
. A single dose of ceftriaxone intramuscularly
. A single dose of procaine penicillin G intramuscularly
. Erythromycin orally for 5 days
. Penicillin V orally for 5 days
1415) An 18-year-old college student, who has recently become sexually active, is seen for severe primary dysmenorrhea. She does not want to get pregnant, and has failed to obtain resolution with heating pads and mild analgesics. Which of the following medications is most appropriate for this patient?
. Prostaglandin inhibitors
. Narcotic analgesics
. Oxytocin
. Oral contraceptives
. Luteal progesterone
1446) An 82-year-old man develops severe abdominal distention, nausea, vomiting, and colicky abdominal pain. He has not passed any gas or stools for the past 12 hours. His vital signs are normal, and his pulse is regular. He has a distended, tympanitic abdomen, with hyperactive, highpitched bowel sounds. There are no signs of peritoneal irritation. Rectal examination is negative for masses or occult blood, and trie rectal vault is empty. Abdominal xray films show distended loops of small and large bowel, as well as a very large round gas shadow that is located in the right upper quadrant and tapers toward the left lower quadrant in the shape of a parrot's beak. The patient has never had any abdominal surgery, and he does not have any palpable hernias. Which of the following is the most appropriate next step in management?
Nasogastric suction, IV fluids, and observation
Repeated enemas and laxatives
Emergency celiac and mesenteric arteriogram
Proctosigmoidoscopy
Emergency exploratory laparotomy
1460) An imaging study detects a 3.5 cm abdominal aortic aneurysm in a 60-year-old male. He has no associated symptoms. His past medical history is significant for hypertension, type 2 diabetes, hypercholesterolemia and hypothyroidism. His medications include aspirin, metformin, glipizide, hydrochlorothiazide, lisinopril, low dose atorvastatin and levothyroxine. He has smoked 1-2 packs of cigarettes daily for the past 40 years, and he drinks 1-2 glasses of wine daily. On physical examination, his blood pressure is 160/90 mmHg and his pulse is 80/min. Heart sounds are normal and his lungs are clear. Laboratory studies show: Serum creatinine 1.7 mg/dL, Low density lipoprotein (LDL) 150 mg/dL, HbA1C 8.5%, Serum TSH 3.0. Which of the following interventions would most reduce the likelihood of his aortic aneurysm enlarging?
. Better control of hypertension
. Better control of hypercholesterolemia
. Better control of diabetes
. Smoking cessation
. Alcohol cessation
1471) An otherwise asymptomatic 65-year-old man with diabetes presents to the ER with a sports-related right shoulder injury. His heart rate is noted to be irregular, and this ECG is obtained. Which of the following is the best immediate therapy?
 
 
A
. Atropine
. Isoproterenol
. Pacemaker placement
. Electrical cardioversion
. Observation
1475) An upper GI series is performed on a 71-year-old woman who presented with several months of chest pain that occurs when she is eating. The film shown here is obtained. Investigation reveals a microcytic anemia and erosive gastritis on upper endoscopy. Which of the following is the most appropriate initial management of this patient?
 
A
. Cessation of smoking, decreased caffeine intake, and avoidance of large meals before lying down
. Antacids
. Histamine-2 blocker
. Proton-pump inhibitor
. Surgical treatment
1496) Following pelvic gynecologic surgery, a 34-year-old woman becomes dyspneic, her peripheral arterial O2 saturation falls from 94% to 81%, and her measured PaO2 is 52 on a 100% non-rebreather mask. She is hemodynamically stable. A CT angiogram is consistent with a right lower lobe pulmonary embolus. Which of the following is the next step in her management?
. Systemic anticoagulation with heparin infusion
. Systemic anticoagulation with warfarin
. Placement of an inferior vena cava filter
. Thrombolytic therapy
. Open pulmonary embolectomy
1507) In your discussion with the patient regarding the risks and benefits of the different management options listed above,which of the following values should you quote regarding the expected 5-year survival rate following curative surgical resection?
. 5–10%
. 15–20%
. 25–35%
. 40–50%
. 60–70%
1511) On a routine annual examination, a 43-year-old woman is found to have a 2-cm mass in the lateral aspect of her right breast. Which of the following is the most appropriate next step in management?
Repeat the breast examination after her next menses
Mammography
Fine-needle aspiration
Open biopsy
Segmental resection
1517) Six months ago at the time of lumpectomy for breast cancer, a 60-year-old female attorney quit a 30-year smoking habit of 2 packs per day. She had the chest radiograph shown here as part of her routine follow-up examination. Based on her age and history of smoking, you are concerned for either a new primary lung or metastatic breast malignancy. Which of the following is the most appropriate next step in the management of this lesion?
. Follow-up CT scan in 3 months
. Magnetic resonance imaging of bilateral breasts to evaluate for recurrence of the breast cancer
. Transthoracic fine-needle aspiration of the lesion
. Mediastinoscopy
. Thoracotomy with lobectomy
1547) You are asked to evaluate a 4-year-old boy admitted to your local children’s hospital with a diagnosis of pneumonia. The parents state that the child has had multiple, intermittent episodes of fever and respiratory difficulty over the past 2 years, including cyanosis, wheezing, and dyspnea; each episode lasts for about 3 days. During each event he has a small amount of hemoptysis, is diagnosed with left lower lobe pneumonia, and improves upon treatment. Repeat radiographs done several days after each event are reportedly normal. His examination on the current admission is significant for findings similar to those described above, as well as digital clubbing. Which of the following is the most appropriate primary recommendation?
Intravenous cephalosporin and oral macrolide therapy
Modified barium swallow study to evaluate for aspiration
Nasal swab for viral culture
Incentive spirometry
Bronchoalveolar lavage
1556) You are counseling a new mother and father on the risks and benefits of circumcision for their 1-day-old son. The parents ask if you will use analgesia during the circumcision. What do you tell them regarding the recommendations for administering pain medicine for circumcisions?
. Analgesia is not recommended because there is no evidence that newborns undergoing circumcision experience
. Analgesia is not recommended because it is unsafe in newborns.
. Analgesia in the form of oral Tylenol is the pain medicine of choice recommended for circumcisions.
. Analgesia in the form of a penile block is recommended.
. The administration of sugar orally during the procedure will keep the neonate preoccupied and happy.
1580) You have just diagnosed a 21-year-old infertile woman with polycystic ovarian syndrome. The remainder of the infertility evaluation, including the patient’s hysterosalpingogram and her husband’s semen analysis, were normal. Her periods are very unpredictable, usually coming every 3 to 6 months. She would like your advice on the best way to conceive now that you have made a diagnosis. Which of the following treatment options is the most appropriate first step in treating this patient?
. Dexamethasone
. Gonadotropins
. Artificial insemination
. Metformin
. In vitro fertilization
1588) Your patient had an ultrasound examination today at 39 weeks gestation for size less than dates. The ultrasound showed oligohydramnios with an amniotic fluid index of 1.5 centimeters. The patient’s cervix is unfavorable. Which of the following is the best next step in the management of this patient?
. Admit her to the hospital for cesarean delivery
. Admit her to the hospital for cervical ripening then induction of labor
. Write her a prescription for misoprostol to take at home orally every 4 hours until she goes into labor
. Perform stripping of the fetal membranes and perform a BPP in 2 days
. Administer a cervical ripening agent in your office and have the patient present to the hospital in the morning for induction with oxytocin
71) A 27-year-old man complains of poor appetite, loss of interest in his daily activities, and impaired sleep. He has lost 10 pounds over the last two months. He says that he feels regretful about IV drug abuse in his past, but denies having suicidal or homicidal thoughts. He drinks alcohol occasionally but denies regular alcohol consumption or early morning drinking. He is sexually active with one partner and she uses oral contraceptives. On physical examination, his pulse is 76/min and his blood pressure is 110/70 mm Hg. His heart and lung exams are unremarkable and his abdomen is soft and non-tender. The liver span is 9 cm and the spleen is not palpable. He is fully oriented to person, place and time but performs poorly on memory tests. Which of the following is the best next step in managing this patient?
Selective serotonin reuptake inhibitors
. Benzodiazepines
. HIV testing
. Thyroid function testing
. Serum iron studies
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