Kdental phamaco
1. For antibiotic agent to be useful in the treatment of pathology microorganism, the following criteria should be met:
The concentration of the antibiotic achieved and maintained at the site of infection.
Not promote resistance or create imbalance of the normal flora of the body. The microorganism must be susceptible to the agent
All above are correct
The agent should be low toxicity for the body.
2. The bactericidal antibiotic?
Penicillin, Cephalosporin
Macrolides
Tetracycline
Clindamycin
3. The bacteriostatic antibiotic
Macrolides , Tetracycline and Clindamycin
Macrolides
Tetracycline
Clindamycin
Cephalosporin
4. Erythromycin belong to which classification of drug?
Macrolide
Clindamycin
Lincomycin
Cephalosporin
5. Mechanism of action of Erythromycin
Narrow spectrum
Bactericidal
Bacteriostatic
Broad spectrum
6. Is the any crossover allergy between Penicillin and Macrolid?
Yes, there is crossover allergy
When use lower concentration
No, there is no crossover allergy
When use high dosage
7. What is the spectrum of activity of Macrolides?
Anaerobic bacteria
Gram (+)
Some Gram (-)
Streptococcus
All the above are correct
8. Can cephalosporin be given to the patient allergic to PNC?
Yes if we use low dosage
No
Yes
Yes if combine with other antibiotic
9. Can bacteria become resistance to PNC?
If we do not use in long period of time
Yes, if bacteria secrete Penicillinase
No it is a good alternative choice
If we combine with other antibiotic
10. What can we give to patient if amoxicillin does not work?
All the above
Amoxicillin, Clavulanic acid
Macrolide
Clindamycin
11. Erythromycin belong to which classification of drugs?
Clindamycin
Cephalosporin
Macrolides
Tetracycline
12. What is the spectrum activities of erythromycin?
All the above
Gram positive bacteria
Gram negative bacteria
anaerobic bacteria
13. What is the mechanism of action of Erythromycin?
Broad spectrum
Bacteriostatic antibiotic
Bacteriocidal antibiotic
Narrow spectrum
14. Can cephalosporin be given to patient allergic to PNC?
Yes if combine with macrolide
No, Because it has same structure to PNC
Yes, If using low dose
Broad spectrum than PNC
15. Are there any crossover allergy between PNC and Erythromycin?
Yes, if used long period
Yes, the structure are similar
No, Without any crossover
Yes If use in the same time
16. What is the different between Azithromycin and Clarithromycin?
Clarithromycin is nephrotoxic
Both are classified as Macrolides 2nd generation
Azithromycin is more effective than clarithromycin
Azithromycin are broad spectrum than Clarithromycin
17. Is Azithromycin is adequate to prescribe in oral infection?
All the above
It has activity against many gram (+)
It has activity against gram( -)
It has activity against anaerobic bacteria
It is an alternative choice when the patient allergic to PNC
18. What is the mechanism of action of Lincomycin?
Bacteriostatic at low does and bacteriocidal at usual dose
Bacteriostatic at low dose
Inhabit bacterial protein
Can be bacteriocidal in low dose
Narrow spectrum
19. Why Metronidazole alone not recommended in odontogenic infection ?
With Macrolide + metronidazole effective against gram (-) and gram (+)
Because
Metronidazole not effective against staphylococcus viridan
Effective against Gram (-) anaerobic
With amoxicillin + Metronidazole effective against gram (-) and gram (+)
All above are correct
20. Does ingestion alcohol when taking Metronidazole cause adverse effects?
Metronidazole prolong Prothrombin time
Yes, Metronidazole and alcohol cause face flushing , headache, papitation and nausea
No, Alcohol increase the effect of metronidazole
Metronidazole is nephrotoxic
21. Why is tetracycline is prescribed for Periodontal disease?
Bacteriostatic antibiotic
Tetracycline releases collgenase and breakdown collagen in (gingival,periodontal and bone)
Tetracycline inhabit bacteria growth
Tetracycline inhibit secretion of salivary gland
22. What is microbial spectrum of the activity of the tetracycline?
Gram (+) bacteria and Gram (-) bacteria
Gram (+) bacteria
Gram (-) bacteria
Candida species
Trichomonase
23. What precaution should be followed when prescribe Azithromycin or Clarithromycin?
All the above
Severe kidney disease
Liver disease
Severe cardiovascular disease
Pregnancy
Breastfeeding
24. What is the spectrum of antibacterial activity of Clarithromycin?
Facultative anaerobic bacteria
Active against gram (+)
Active against gram (-)
Facultative aerobic bacteria
All the above
25. What the indication for the use of acetaminophen?
All the above
Antipyretique
Mild to moderate pain
Peripheral activity anti-inflammatory
Does not inhabit platalet aggregation like Apirin
26. What is the indication for chlorhexidine ?
Pulpitis
Gingivitis
Periodontitis
Apical periodontitis
27. Can bacteria become resistant to PNC?
Used during meal time
Certain gram negative bacteria secrete batalactamase breakdown PNC
If used PNC combine with Tetracycline
Used long period
28. What the drug interaction occur with PNC?
Acetaminophen
Probenecid
Tetracycline
Oral contraceptive
Probenecid , Tetracycline and oral contraceptive
29. For which common oral condition is antiviral appropriate?
Gingivitis
Herpes simplex virus
Candida’s infection
Staphylococcus infection
30. What type of alcohol oral rinse?
Listerine
Ethanol
Hydrogen Peroxide
Methanol
31. What is the precaution /Contra indication of using Clindamycin in the patient?
Severe renal disease
With inflammatory bowel
With ulceration colitis
Pseudomembranous colitis
All the above
32. Metronidazole reserve for the treatment of
All the above
Serious infection of lower respiratory tract
Infection of skin and soft tissue
Infection of joint and bone
Bacterial septicemia involving gram (-) and gram (+) anaerobic and clastidium species
Metronidazole has been reported to potentiated prolong prothombin time when combine with anticoagulant below:
Ibuprofen
Warfarin
Coumadin
Acetaminophen
Warfarin- Coumadin
34. What are some adverse effects of oral nystatin
All the above
Diarrhea
Nausea
Vomiting
Rash
35. Can Antacids and Iron be taken without Tetracycline?
If we increase the usual dose.
Yes, if we add vitamin B
No, Antacids and Iron can not take same time because reduce abortion
If combine with other antibiotic
36. The Function of irrigant Sodium hypochlorite use during root canal therapy!!
To flush debris from the canal, Lubricate the canal and Disinfect the canal
To flush debris from the canal
Lubricate the canal
Disinfect the canal
Keep the vitality of pulp
37. The irrigants us in root canal therapy are :
Sodium hypochlorite, Ethylenediaminetetraacetic acid (EDTA) and Hydrogen Peroxide 3% (H2O2)
Sodium hypochlorite
Ethylenediaminetetraacetic acid (EDTA)
Hydrogen Peroxide 3% (H2O2)
Eugenol
38. Why Metronidazole alone not recommended in odontogenic infection ? Because:
All above are correct
Metronidazole not effective against staphylococcus viridan
Effective against Gram (-) anaerobic
With amoxicillin + Metronidazole effective against gram (-) and gram (+)
With Macrolide + metronidazole effective against gram (-) and gram (+)
39. Pharmacology of Clindamycin:?
All the above
Adsorption not influenced by the presence of the food
Widely distributed to many fluid well and tissues
Distributed in the bone
Absorbed from the stomach
40. Metronidazole has been reported to potentiated prolong prothombin time when combine with anticoagulant below:?
Warfarin- Coumadin
Warfarin
Coumadin
Acetaminophen
Ibuprofen
41. 37 The Function of irrigant Sodium hypochlorite use during root canal therapy?
To flush debris from the canal
Lubricate the canal
Disinfect the canal
Keep the vitality of pulp
1 +2 +3 Lubricate the canal Disinfect the canal Disinfect the canal
42. The irrigants us in root canal therapy are ?
Sodium hypochlorite, Ethylenediaminetetraacetic acid (EDTA) and Hydrogen Peroxide 3% (H2O2)
Sodium hypochlorite
Ethylenediaminetetraacetic acid (EDTA)
Hydrogen Peroxide 3% (H2O2)
Eugenol
43. Is Azithromycin adequate to prescribe in oral infection?
Good Choice for mild infection
Has activity against gram positive bacteria
Has activity against gram negative bacteria
When patient is allergic to PNC
All the above are correct
44. Activity of Azithromycin
Against gram (+) bacteria and Against gram (-) bacteria
Against gram (+) bacteria
Against gram (-) bacteria
Entameba Histolica
Plasmodium folciform
45. What precaution should be followed when prescribe azithromycin ?
All above are correct
Severe liver disease
Liver cirrhosis
Severe kidney disease
Severe cardiovascular disease
46. What are advantages to prescribe azithromycin or clarithromycin over erythromycin?
Higher tissue concentration than Erythromycin
More acid stable than erythromycin
Not broken down in the acidity of the stomach
Better tissue penetration than Erythromycin
All the above are correct
47. Can we prescribe Clarithromycin to patient allergic to PNC?
Breakdown in the acidity gastric
Yes
No
Not derivative from Erythromycin
48. What are some drug interaction with azithromycin?
Carbamazepine
Warfarin
Digoxin
Theophylline
All the above are correct
49. Drug interaction with Azithromycin?
Warfarin and Carbamazepine
Vitamin C
Warfarin
Carbamazepine
Paracetamol
50. Drug interaction with tetracycline?
All the above are correct
Antacid if take the same time
PNC if take the same time
Digoxin
Warfarin
51. What is the spectrum of antibacterial action for metronidazole?
Gram (+) Bacteria, Gram (-) Bacteria and Fusobacterium
Gram (+) Bacteria
Gram (-) Bacteria
Anaerobic
Fusobacterium
52. Do Metronidazole concentrate in gingival crevicular fluid (GFC)?
Lymph node
No
Yes
Bone Marrow
53. Why Metronidazole alone not recommended in odontogenic infection?
Active against gram (+), Anaerobic germ and Staphylococcus gram (+)
Active against gram (+)
Active against gram (-)
Anaerobic germ
Staphylococcus gram (+)
54. What is the spectrum of activity of Clindamycin?
Staphylococcus
Narrow spectrum antibiotic
Against most gram (+)
Gram (-)
All the above are correct
55. What is the spectrum of activity of Clindamycin?
Anaerobic bacteria
Narrow spectrum
Broad spectrum
Bactericidal
56. Is Clindamycin a good choice in odontogenic infection?
All the above are correct
Against anaerobies
Good distribution in soft tissue
Well distribution in the bone
Show high plasma concentration
57. What are the common adverse effect of Clindamycin?
All the above are correct
Diarrhea
Vomiting
Abdominal pain
Rash
58. Is Clindamycin contra-indicated in any patient?
No, Patient with inflammation bevel disease and Ulcerative colitis
No
Yes
Patient with inflammation bevel disease
Ulcerative colitis
59. If patient is allergic to Erythromycin can Clindamycin be prescribed?
Bactericidal
Yes , mechanism of action relatively the same
No, because of allergy
Different antibiotic spectrum
60. Antibiotic bacteriostatic?
Macrolide and Tetracycline
Macrolide
Quinolone
Penicillin
Tetracycline
61. Drug interaction with macrolide?
Digoxin
Alfentanil
Theophyline
Carbamazepine
All the above are correct
62. Tetracycline Is medicated in?
All the above are correct
Refractory Periodontitis
An alternative when PNC is contra-indicated
When β- lactamase are involved
Dental Abscesses
63. Erythromycin , Clarithromycin and Azithromycin are indicated in the treatment of ?
Alternative treatment to PNC
Mild to moderated infection of oral cavity
Upper and lower inspiratory tract infection
Skin infection
All the above are correct
64. Erythromycin , Azithromycin are eliminated from the body by
The saliva
The liver
The kidney
The lung
65. Once absorbed PNC distribute through out the body include:?
Placenta
Gingival crevicular fluid
Saliva
Blood Brain
Gingival crevicular fluid, Saliva and Placenta
66. For the antimicrobial to be useful in treatment of pathogenic microorganism. The following criteria should be met:?
The agent should not be readily promote resistance or create imbalance in the normal flora, The agent must be capable of penetrate in the site of infection and The agent should be toxic to the body
The agent should not be readily promote resistance or create imbalance in the normal flora
The agent must be capable of penetrate in the site of infection
The agent should be toxic to the body
Capable to provoque cell multiplication
67. Treatment of Doxycycline in refractory periodontitis?
All above are correct
20mg q.12h
As an adjunctive periodontal therapy
Mechanism of action is suppression collagenase
The therapeutic objective : Help kill the bacteria
68. What is the spectrum of antibacterial action for metronidazole?
All the above are corret
Effective against gram (-)
Anaerobie Germ
Fuso Bacterium
Polyimonas
69. Do ingestion of alcohol cause adverse effect when taking metronidazole?
Cause Nausea , abdominal cramp, Facial Flushing , Headache and Confusion
No side effects
Cause Nausea , abdominal cramp
Facial Flushing , Headache
Confusion
70. Clindamycin: indication for use in ?
All the above are correct
Treatment of severe infection cause by anaerobia bacteria
Treatment of adult refractory periodontitis
Alternative to PNC
Alternative to Erythromycin
71. Oral candida infection may have four clinical presentation ?
Angular chelitis
Pseudomembranous
Erythematous Candidiasis
Hyper plastic candidiasis
All the above are correct
72. Candida infection may have four clinical presentations
Pseudomembranous and Erythematous Candidiasis
Pseudomembranous
Edema of mucosa
Hyperplasia of lip
Erythematous Candidiasis
73. Candidas infection may be diagnosed through?
Culture and Cytological smears
Culture
Cytological smears
Biopsy
White blood cell count
74. Antifungal agent divided into two group?
Azole : imidazole . clotrimazol and Polynene
Azole : imidazole . clotrimazol
Polynene
Suffonamid
Clotrimazol
75. Antifungal agent : possible interaction between other drug?
Warfarin
Alcohol
Benzodiazepine
Dogoxin
All the above are correct
76. Antifungal agent : possible interaction with :?
Benzodiazepine
Cephalosporin
Azithromycin
Clindamycin
77. Oral viral infection encountered in dental practice:?
All the above are correct
Herpangina
Acute lymphonodular pharyngitis
Hand- food and mouth disease
78. The oral fungal infection are treated with?
All the above are correct
Azole
Polyene
Ketakonazole
Imidazole
79. The following advice can be given to all patient diagnosed with oral fungal infection?
Oral hygiene devices such as toothbrush and denture that maybe contaminate should be replaced
To prevent relapse long term therapy
Take medication should complete the course
Patient should not use alcohol base mouth rinse
All above are correct
80. Contra indication of amoxicillin + Clavulanic acid?
Congestion heart failure
Hypersensitivity to PNC
Liver disease
Refractory periodontitis
81. Amoxicillin + Clavulanic acid indication:?
All the above are correct
Severe dental infection
Cellulitis
Surgical prophylaxis
Respiratory tract infection
82. The Precaution of using amoxicillin + Clavulanic acid?
All the above are correct
History of allergy to PNC
Erythematous rash
Hepatic impairment
Renal impairment
83. Ontra-indication of amoxicillin :?
Cyst
Hypersensitivity to PNC
Gingivitis
Cellulitis
84. Contra-indication of amoxicillin?
Dental Abscess
History of allergy to PNC
Bronchitis
Oral infection
85. Indication of use cephalosporin 1st generation :?
Coxakie-virus
Gram (+) bacteria infection
Gram (-) bacteria infection
Anaerobic bacteria infection
86. The alternative choice of using amoxicillin + Clavulanic acid?
Azithromycin, Clindamycin and Lincomycine
Azithromycin
Clindamycin
Metronidazole
Lincomycine
87. Phenoxyl methyl Penicillin (PNC V) indication for use: ?
All the above are correct
Streptococcus Pharyngitis
Cellulitis
Otitis
Mouth infection
88. Phenoxyl methyl Penicillin precaution of use?
All the above are correct
Allergy to PNC
Breastfeeding
Patient are resistance to PNC
Severe kidney disease
89. Contra indication of Doxycycline:?
Pregnancy, Children under the age of 8 years and Renal Failure
Pregnancy
Children under the age of 8 years
Patient who are allergy to PNC
Renal Failure
90. Indication of Erythromycin:?
All the above are correct
Alternative to PNC
Oral infection
Sinusitis
Respiratory tract infection
91. Metronidazole , Indication of use:?
Streptococcus infection
Anaerobic bacterial infection
Bacterial infection
Staphylococcus infection
92. Oral viral infection encounter in dental clinic?
All the above are correct
Herpangina
Acute lymph nodular pharyngitis
Herpes labials
Human papilloma virus
93. For the patient with immuno competent , the treatment of oral herpetic consist of :?
Nutritional support
Treatment of anti-fungus
Nutritional support and Pain Palliaition
Pain Palliaition
Antibiotherapy
94. For the patient with immuno compromised the treatment of oral herpetic consist of :?
All the above are correct
Nutrition support
Analgesic
Topical anesthesia cream
Anti-viral ( Acyclovir)
95. Patient with Hiv infection , the treatment of oral viral infection consist of :?
All the above are correct
Treatment of anti-viral
Analgesic
Nutrition support
Topical anesthesia cream
96. Patient with HIV infection , the treatment of oral viral infection consist of :?
Anti-viral therapy
Analgesic therapy
Antibiotherapy
Anti-fungus
Analgesic therapy and Anti-viral therapy
97. Because the toxicity and side effect, antiviral agent usually are reserve for:?
Patient with immunocompromised and Patient with immuno deficiency
Patient with immunocompromised
Patient with immuno deficiency
Immono competent
The elderly people
98. Clindamycin: interaction with other drugClindamycin + Anti diarrhea containing Kaolin or actapulgite:?
May increase plasma level of clindamycin
May delay absorption of oral clindamycin
May prolonged respiratory depression
May increase activity of warfarin
99. Adverse effect of Clindamycin:?
May increase activity of conmadin
Result in disturbance of normal intestinal flora
Provoque severe colitis
Renal Disease
100. Ciprofloxaxin indication in the treatment of infection by :?
Streptococcus pyogen
Gram (-) Bacteria
Anaerobic bacteria
Staphylococcus epidermitis
All above are correct
101. Ciprofloxazin : Characteristics ?
Inactive against anaerobic bacteria
Bactericidal
Activity against gram (+)
Activity against gram (-)
All above are correct
102. Metronidazole : after oral administration?
Cerebro spinal fluid
Drug distribution throughout the body
Drug penetrate well into body fluid
Drug penetrate in saliva
All the above are correct
103. After oral administration , Metronidazole distributed?
Into the saliva, In the cerebrospinal fluid and In the body tissues
Into the saliva
In the cerebrospinal fluid
In the body tissues
In the bone
104. Characteristic of Ciprofloxacine
Inactivity against anaerobic bacteria
Bactericidal
Activity against gram (+)
Activity against gram (-)
All the above are correct
105. Characteristic of Ciprofloxacine?
Bactericidal and Inactivity against anaerobic bacterial
Bacteriostatic
Bactericidal
Inactivity against anaerobic bacteria
106. Common indication for use of penicillin + Clavulanic acid?
correct Against β-lactamase producing by pathogen agent, To prevent prosthetic join infection and For dental patient at risk
Against β-lactamase producing by pathogen agent
To prevent prosthetic join infection
For dental patient at risk
against anaerobic bacteria
107. If patient allergic to Penicillin can we prescribe Ciprofloxacin ?
No because the patient is allergic to PNC
No there are cross resistance between antibiotic
Yes
The Mechanism of action is the same
108. When are quinolone prescribed in dentistry?
Fluid concentration is high
If pathogen agent are resistance
If the patient is allergic to PNC
Bactericidal antibiotic
109. Spectrum activity of quinolone ?
Broad spectrum antibiotic, Against anaerobic bacteria gram (-) microorganism and Against many gram (+)
Broad spectrum antibiotic
Against anaerobic bacteria gram (-) microorganism
Against many gram (+)
Patient is allergic to PNC
110. What are the adverse effect of quinolone?
All above are correct
Nausea
Vomiting
Diarrhea
Dizziness
111. Does Pseudomembranous Colitis occur with ciprofloxacin ?
If we use with PNC
No there are no relation with ciprofloxacin and colitis
Yes there is high association and clostidium difficile
The mechanism of action is different
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