Anemia

A 52-year-old man presents to your clinic complaining of fatigue. He reports he has a history of anemia and was told it was from vitamin B12 deficiency. He has been taking vitamin B12 for the last six months with little improvement. He is beginning to notice numbness and tingling in his feet. Which of the following would be the next best step in diagnosis?

A 55-year-old woman on long-term metformin therapy presents with progressive fatigue over the last 6 months. She is known to drink three glasses of wine a night and has had moderate transaminitis for years. A complete blood count demonstrates a macrocytic anemia with a hemoglobin of 8 g/dL. Aspartate aminotransferase and alanine aminotransferase remain elevated at 150 U/L and 110 U/L, respectively. Serum vitamin B12 is measured at 155 ng/L. Which of the following is the most appropriate diagnostic test to confirm your suspicion of vitamin B12 deficiency as a cause of her anemia and fatigue?

42-year-old woman is incidentally found to have a microcytic, hypochromic anemia with normal red blood cell distribution width. Which one of the following tests would confirm your suspected diagnosis?

A 35-year-old man who has been on a vegan diet for many years presents for a routine checkup. He reports feeling well. Examination is normal. His CBC shows a mild macrocytic anemia and hypersegmented neutrophils on peripheral smear. Vitamin B12 level is 120 pg/mL (normal > 200 pg/mL). Anti-intrinsic factor and anti-parietal cell antibodies are negative, and gastrin level is normal. According to the British Society for Haematology, which of the following is an appropriate vitamin B12 treatment regimen in this patient?

In beta thalassemia trait, hemoglobin electrophoresis will typically demonstrate which of the following findings?