Test your knowledge on acute lymphoblastic leukemia

What is the most common age group diagnosed with acute lymphocytic leukemia?
Infants
Children aged 2-5 years
Adults aged 20-40 years
Elderly aged 60+ years
Which of the following is a hallmark cytogenetic abnormality associated with poor prognosis in acute lymphocytic leukemia?
t(12;21) ETV6-RUNX1
Hyperdiploidy
t(9;22) BCR-ABL1
t(1;19) TCF3-PBX1
What is the primary site of origin for acute lymphocytic leukemia?
Myeloid stem cells in the bone marrow
Lymphoid stem cells in the bone marrow
Peripheral lymph nodes
Thymus
Which of the following symptoms is least likely to be associated with acute lymphocytic leukemia?
Fatigue
Fever
Bone pain
Diarrhea
Which of the following laboratory findings is commonly observed in acute lymphocytic leukemia?
Leukocytosis with blast cells in the peripheral blood
Elevated hemoglobin levels
Low platelet count
Both A and C
What is the primary diagnostic test for confirming acute lymphocytic leukemia?
Peripheral blood smear
Bone marrow biopsy and flow cytometry
Chest X-ray
Lymph node biopsy
Which immunophenotype is associated with T-cell acute lymphocytic leukemia?
CD10+, CD19+
CD13+, CD33+
CD2+, CD7+
CD34+, CD117+
What is the first-line treatment for newly diagnosed acute lymphocytic leukemia?
Radiation therapy
Chemotherapy
Bone marrow transplant
Targeted immunotherapy
Which chemotherapy regimen is typically used during induction therapy for acute lymphocytic leukemia?
Prednisone, vincristine, L-asparaginase, and doxorubicin
Cyclophosphamide, doxorubicin, vincristine
Methotrexate, fluorouracil, and cisplatin
Imatinib and dasatinib
Minimal residual disease in acute lymphocytic leukemia is assessed primarily by:
Bone marrow biopsy under light microscopy
Polymerase chain reaction, flow cytometry, or next generation sequencing
Complete blood count and PET scan
PET scan only
What is the role of CNS prophylaxis in acute lymphocytic leukemia treatment?
To treat existing CNS disease
To avoid radiation therapy
To prevent leukemic infiltration of the CNS
To reduce cardiotoxicity
What is the most common complication of acute lymphocytic leukemia treatment?
Tumor lysis syndrome
Rash
Pulmonary fibrosis
Pulmonary embolism
What is the five-year survival rate for pediatric patients with acute lymphocytic leukemia?
20-30%
50-60%
70-80%
90% or higher
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