M&P
Musculoskeletal and Pathophysiology Quiz
Test your knowledge on musculoskeletal diseases, treatments, and anatomical concepts with our comprehensive quiz designed for healthcare professionals and students alike. This quiz covers important topics such as disease mechanisms, diagnostic procedures, and treatment options, helping you enhance your understanding and practical skills.
Key Features:
- 35 well-researched questions
- Diverse question formats including multiple choice and descriptive
- Focus on pathology, pharmacology, and anatomy
What is the target of denosumab?
Inhibit RANK-Ligand
Inhibit RANK-Receptor
Inhibit Sclerostin
Activate RANK-Receptor
Inhibit RANK-Ligand release
What is a reverse hybrid hip transplant?
Cemented femoral head + uncemented acetabulum
Cemented acetabulum + uncemented femoral head
Titanium pins in femur + no titanium pins in acetabulum
Titanium pins in acetabulum + non titanium pins in femoral head
A 48 yo male patient comes in complaining of sudden onset pain in his big toe that began in the middle of the night. An aspirate of the 1st MTP joint was taken and a crystal microscopy of the aspirated synovial fluid showed the presence of strongly negatively birefringent crystals. Given the likely diagnosis, what is the method of action of the 1st line prophylactic drug of choice?
Reversible non-selective COX inhibitor
Reversible COX-2 inhibitor
Blocks mitotic division of cells in metaphase
Xanthane Oxidase inhibitor
Phospholipase A2 inhibitor
A patient has just had a mastectomy. However, a doctor noticed that when the patient places their hands on the wall in front of them at shoulder height, their back appears asymmetrical, with one shoulder blade protruding at a greater angle than the other. What are the nerve roots of the injured nerve?
C7-T1
C5-C7
Spinal root of accessory nerve
T3-T5
C5-T1
A 68yo female patient comes in complaining of hip pain, a DEXA scan shows she has a T score of -2.64. Which of these is a potential side-effect of the 1st line pharmacological intervention of the patients condition?
Tachycardia
Osteonecrosis of the jaw
Hypercalcaemia
Diarrhoea
Constipation
What are the 3 stages in the pathophysiology of Paget's disease briefly describe what happens in each.
During a lumbar puncture which of these structures is not perforated?
Ligamentum Flavum
Posterior Longitudinal Ligament
Interspinous Ligament
Supraspinous ligament
Epidural fat
A 58yo male comes in complaining of a noticeable decrease in his grip strength. Blood tests show slightly elevated creatine kinase levels. A muscle biopsy shows infiltration of CD8+ lymphocytes and macrophages into the muscular tissue, it is also noted that some muscle fibres contain vacuoles. What is the likely diagnosis?
Dermatomyositis
Polymyositis
Duchenne Muscular Dystrophy
Becker Muscular Dystrophy
Inclusion Body Myositis
Systemic Lupus Erythematosus is a type ? hypersensitivity, characterised by high levels of ? Autoantibodies and first line treatment of mild SLE is ? - fill in the '?'
A patient sustains a mid shaft humeral fracture, which nerve is most at risk?
Musculocutaneous
Axillary
Median
Radial
Ulnar
The same patient dislocates their humeral head from their glenoid socket, what nerve is most at risk?
Musculocutaneous
Axillary
Median
Radial
Ulnar
Again, the same patient sustains a supracondylar fracture of the humerus, how would injury to the nerve most at risk in this fracture present?
Ulnar claw
Hand of benediction
Loss of sensation to the dorsum of the hand
Complete loss of function of flexor digitorum profundus
Complete loss of function of adductor pollicus
Once again, the same patient sustains a medial epicondylar fracture at his elbow, which muscle/muscle group would undergo the most noticeable atrophy?
Thenar eminence
Hypothenar eminence
Flexor digitorum profundus
Flexi carpi ulnaris
2nd lumbrical
A 23yo woman comes into to the ED with a hot red swollen knee, she is diagnosed with SA and a joint aspirate is taken. Gram staining of the aspirate revealed a gram-negative diplococcus, what is the most likely causative agent?
Staphylococcus aureus
Neisseria gonorrhoea
Group A Streptococcus
Haemophilus influenza
Escherichia coli
Which of these DMARDs interferes with pyrimidine synthesis?
Methotrexate
Leflunomide
Sulfasalzine
Hydroxychloroquine
Rituximab
Which of these DMARDs is safest to give during pregnancy?
Methotrexate
Leflunomide
Infliximab
Hydrochloroquine
Rituximab
Sarilumab is an inhibitor of IL-?, whereas Tolcilizumab is an inhibitor of the receptor for the same interleukin
IL-1
IL-6
IL-8
IL-17
IL-23
A patient with diabetic neuropathy has significant damage to their common peroneal nerve, what type of gait would this cause?
Spastic gait
Scissor gait
Steppage gait
Shuffling gait
Waddling gait
A patient with damage to their corticospinal tract will present with what type of gait
Spastic gait
Waddling gait
Cerebellar ataxia
Shuffling gait
Sensory ataxia
A patient with proximal muscle weakness of their lower limbs will present with what type of gait?
Sensory ataxia
Scissor gait
Cerebellar ataxia
Shuffling gait
Waddling gait
Which layer of the skin is made up of dead keratinocytes?
Stratum Basale
Dermis
Stratum Corneum
Stratum lucidum
Stratum granulosum
What are the nerve roots of the sciatic nerve?
L3-L5
S2-S4
L3-S2
L4-S3
L2-L4
Which vein is commonly used for venepuncture?
Short saphenous vein
Cephallic vein
Median cubital vein
Basilic vein
Brachial vein
Which three muscle/muscle groups are involved in the 'toe off' stage of the gait cycle?
Iliopsoas, quadriceps femoris, anterior compartment of leg
Quadriceps femoris, foot inverters + evertors, gluteus medius
Gluteus maximus, quadriceps femoris, anterior compartment of leg
Hamstrings, quadriceps femoris, posterior compartment of leg
Iliopsoas, quadriceps femoris, posterior compartment of leg
A patient comes in with a pain on lateral abduction of the arm at the shoulder joint at roughly around 80* to 120*, which muscle is impinged?
What is the drug target of secukinumab ?
TNF-Alpha
IL-1
IL-17
IL-23
Phospholipase A2
A patient comes in with uveitis, they are positive for Schober's test and upon genetic testing it is found they have the HLA-B27 gene. Which of these x-ray signs is indicative of the likely diagnosis?
Subchondral calcification
Bamboo Spine
Disruption of Perkin's line
Osteophytes
Disruption of Hilgenreiners line
Which of these statements regarding osteoarthritis is untrue?
It is worse after activity
In the cartilage collagen type 2 fibres are replaced by collagen type 1 fibres
Bouchards nodes form at the DIP
Patients are often prescribed a proton pump inhibitor
Being biologically female is a risk factor
Which of these statements involving joints found across the body is untrue?
The MCP is a saddle joint
The pubic symphysis is a cartilaginous joint with elastic cartilage
The acromioclavicular joint is a plane joint
The intervertebral discs are a type of fibrocartilaginous joint
The joint between the parietal and temporal bone is fibrous
Which of these statements involving bone ossification is true?
Endochondral ossification happens around a fibrocartilage model
The clavicle is formed by intramembranous ossification
During intramembranous ossification there is a blood supply throughout the entire process
During Endochondral ossification there is a blood supply throughout the entire proces
There are many secondary ossification sites during intramembranous ossification
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