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(361.1) Midazolam or Diazepam for Seizures

1. What is the mechanism of action of benzodiazepines?
A. Inhibits voltage-dependent Na+ channels
B. Binds to synaptic vesicle protein 2A
C. Inhibits T-type Ca2+ channels
D. Binds to the ī§-subunit GABAA receptors
E. None of the above
2. Oral administration of diazepam to cats may lead to:
A. Acute hepatic necrosis
B. Pancreatitis
C. Eosinophilic pneumonitis
D. Necrolytic dermatitis
E. None of the above
3. Benzodiazepines ultimately cause:
A. Hypo-polarization of the cell membrane and facilitation of neurotransmission
B. Hyperpolarization of the cell membrane and facilitation of neurotransmission
C. Hyperpolarization of the cell membrane and inhibition of neurotransmission
D. Hypo-polarization of the cell membrane and inhibition of neurotransmission
E. None of the above
4. Midazolam has ______ the binding affinity for GABAA receptors compared to diazepam.
A. 2x
B. 10x
C. 5x
D. 20x
E. None of the above
5. The half-life of diazepam is:
A. 18 hours
B. 2 hours
C. 10 hours
D. 6 hours
E. None of the above
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