MDRV5: Interpreting Culture and Susceptibility

Which of the following is an example of acquired bacterial resistance to an antimicrobial?

Methicillin resistant Staphylococcus pseudintermedius

Pseudomonas aeruginosa resistant to ampicillin

Escherichia coli resistant to vancomycin

Clostridium perfringens resistant to enrofloxacin

An organism can be defined as multidrug resistant if it meets which of the following criteria?

It is resistant to more than one antimicrobial agent

It is resistant to more than three antimicrobial agents within a class of antimicrobials

It is resistant to at least one antimicrobial agent within three different classes of antimicrobials

It is resistant to all but one or two classes of antimicrobials

Which of the following best describes a minimum inhibitory concentration (MIC) of a microorganism and antimicrobial?

The minimum antimicrobial concentration that can be reached in the serum (in vivo) that prevents replication of the microorganism

The minimum antimicrobial concentration that inhibits visible growth of the microorganism in vitro

The minimum antimicrobial concentration that inhibits growth of 99.9% of the microorganism isolated in vitro

The minimum antimicrobial concentration that can be reached in the serum (in vivo) that exceeds the susceptible breakpoint by a factor of 10

Given the following information, which systemic antimicrobial represents the best choice to treat a patient with pneumonia from Pseudomonas aeruginosa?

Drug	MIC (mcg/ml)	Interpretive Criteria
Amikacin	<8	Susceptible
Cefazolin	≥16	Resistant
Chloramphenicol	16	Intermediate
Enrofloxacin	<0.12	Susceptible

Amikacin

Cefazolin

Chloramphenicol

Enrofloxacin

With a “concentration dependent” antimicrobial which of the following options SHOULD NOT be considered when an antimicrobial has an intermediate designation to the antimicrobial prescription?

Increasing the dose of the antimicrobial

Increasing the frequency of administration

Choosing a different antimicrobial

Adding a synergistic antimicrobial

All of the above are options

MDRV5: Interpreting Culture and Susceptibility

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