Test Your Knowledge on Primary Immunodeficiency Diseases
Test Your Knowledge on Primary Immunodeficiency Diseases
Welcome to the Primary Immunodeficiency Diseases Quiz! This quiz is designed to test your understanding of various aspects related to primary immune deficiency diseases, their symptoms, diagnosis, and treatment. Whether you're a parent, a student, or just curious about immunology, this quiz will enhance your knowledge and awareness.
Take the quiz to discover:
- Key indicators of primary immunodeficiency diseases
- Common tests used for diagnosis
- Important conditions associated with immunodeficiencies
Primary immune deficiency diseases are rare conditions
True
False
Frequent or recurrent types of which of the following infections may strongly indicate the presence of a primary immunodeficiency disease?
Streptococcal pharyngitis
Ear and sinus infections
Urinary tract infections
Viral upper respiratory tract infections
Which of the following would be most worrisome for the presence of a primary immunodeficiency disease consisting of a problem with T lymphocyte function?
Recurrent ear, sinus and lung infections
Recurrent thrush or no thymus on CXR
Recurrent skin abscesses or poor wound healing
Recurrent warts
Which of the following would be most worrisome for the presence of a primary immunodeficiency disease consisting of a problem with neutrophil function?
Recurrent ear, sinus and lung infections
Recurrent thrush or no thymus on CXR
Recurrent skin abscesses or poor wound healing
Recurrent warts
My child has a very high serum IgE level. I should be concerned that he or she may have hyper-IgE syndrome if he or she also has which of the following?
Asthma
Eczema
Skin abscesses
Low platelet count
Which of the following tests might a doctor use to evaluate for defective B lymphocyte function in my child?
Measurement of antibody level in the blood
Oxidative burst assay
Skin testing to Candida or mumps
Newborn screening
Which of the following tests might a doctor use to evaluate for defective T lymphocyte function?
Measurement of chloride levels in sweat
Oxidative burst assay
Skin testing to Candida or mumps
Ciliary biopsy
True or false: All patients with primary immunodeficiency diseases require immunoglobulin replacement therapy to prevent infections.
True
False
True or false: Primary immunodeficiency diseases are incurable.
True
False
The most frequently diagnosed form of specific primary immunodeficiency is:
Severe combined immunodeficiency
X-linked agammaglobulinaemia
Chronic granulomatous disease
Selective IgA deficiency
DiGeorge syndrome
Data handling for a diagnosis: Given these results from a 4 year-old child, which one PID is most likely?
[Normal range for age is in brackets]
CD3 T cells 2.6 × 109/1 [1.0”7.2 × 109/1]
CD4 T cells 1.8 × 109/1 [0.5”5.2 × 109/1]
CD8 T cells 0.7 × 109/1 [0.4”2.8 × 109/1]
NK cells 0.4 × 109/1 [0.13”0.8 × 109/1]
B cells 0 × 109/1 [0.2”2.7 × 109/1]
Total lymphocytes 3.3 × 109/1 [1.1”5.2 × 109/1]
CD40 ligand deficiency
Severe combined immunodeficiency
Chronic granulomatous disease
X-linked agammaglobulinaemia
Which one of the following is most pertinent to healthy individuals with selective IgA deficiency?
All individuals can be considered to be normal without risk of infections.
They are more likely to develop heart disease than those with normal IgA levels.
They have a high risk of a recurrent serious bacterial infection.
They have a higher risk of developing an organ specific autoimmune disease than the general population.
Which one of the following is most pertinent to common variable immune deficiency disorders?
Patients always present before the age of 10 years
Is due to a single gene defect on the X chromosome
Patients are treated by replacement immunoglobulin, intravenously or subcutaneously
Most patients die from complications of malignancy
Which one of the following is most pertinent to transient hypogammaglobulinaemia of infancy:
Occurs at 3 months of age
Is more pronounced in premature babies
Is linked with autoimmune disease later in life
Involves only the IgA class
Which one of the following is the primary defect in chronic granulomatous disease [CGD]?
Neutrophil production in bone marrow
Neutrophil chemotaxis
Neutrophil intracellular killing of organisms
Opsonization
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