Target Alteration Quiz
Target Alteration Quiz
Test your knowledge on the role of various signaling pathways and genes in biological processes with our comprehensive Target Alteration Quiz. Dive into a collection of 21 thought-provoking questions designed to challenge your understanding and enhance your learning.
- Assess your comprehension of signal transduction and gene expression.
- Explore the effects of specific genes and proteins in developmental biology.
- Great for students, researchers, and anyone interested in cell signaling!
Addition of **hSlit2** up to a final **concentration** of 1 microg/ml had no detectable effect on the formation of nephrons or on branching morphogenesis of the ureteric tree after 2 or 4 days in culture, as assessed via immunofluorescence for the markers WT1 and calbindin 28K respectively.
Y
N
U
Furthermore, **expression** of **SLIT2** was restored in relatively low-expressing cell lines after treatment with 5-aza-2-deoxycytidine (5-Aza-dC).
Y
N
U
A binding ELISA experiment in mouse bone marrow-derived macrophages showed that ROBO1, rather than ROBO3, was directly associated with SLIT2, and gene silencing with Robo1 siRNA **blocked** the **SLIT2**-mediated suppression of osteoclastogenesis.
Y
N
U
**Overexpression** of orthodenticle homeobox 2 using lentivirus increased levels of known A10 elevated genes, including neuropilin 1, neuropilin 2, **slit2** and adenylyl cyclase-activating peptide in both MN9D cells and ventral mesencephalic cultures, whereas knockdown of endogenous orthodenticle homeobox 2 levels via short hairpin RNA reduced expression of these genes in ventral mesencephalic cultures.
Y
N
U
**Signal transducer and activator of transcription-6** (STAT6) inhibition **suppresses** renal cyst growth in polycystic kidney disease.
Y
N
U
**Wild-type** (WT), **Stat6** knockout (Stat6-/-), and intestinal epithelial cell-specific IL-4Rα knockout (Il-4rαΔIEC) mice were subjected to colitis-associated (AOM/DSS) and colitis-independent (sporadic) carcinogenesis.
Y
N
U
This innate collaboration was absent in IL-4(-/-) and **signal transducer and activator of transcription (STAT)-6** **(-/-)** mice and was inhibited by anti-IL-4 treatment.
Y
N
U
Disruption of the IL-4 signaling through either IL-4 neutralizing **antibody** or knockout of **signal transducer and activator of transcription (STAT)6** reversed the miR-17-92 cluster suppression in Th2 cells.
Y
N
U
To study the role of Slit in early embryos, we **overexpressed** Slit2 in the whole embryos either by injection of its mRNA into one-cell stage embryos or by heat-shock treatment of the transgenic embryos which carries the **slit2** gene under control of the heat-shock promoter.
Y
N
U
This is based on the observation that, although both Slit1 and **Slit2** are **expressed** around the ventral midline, mice defective in either gene alone exhibit few or no axon guidance defects at the optic chiasm whereas embryos lacking both Slit1 and Slit2 develop a large additional chiasm anterior to the chiasm's normal position.
Y
N
U
Identification of single-nucleotide and repeat **polymorphisms** in two candidate genes, interleukin 4 receptor (IL4RA) and **signal transducer and activator of transcription protein 6 (STAT6)**, for Th2-mediated diseases.
Y
N
U
**Inhibitory** Effect of **Slit2-N** on VEGF165-induced proliferation of vascular endothelia via Slit2-N-Robo4-Akt pathway in choroidal neovascularization.
Y
N
U
Using analysis of **knock-out** mice and in vitro assays, we found that, in the mammalian retina, Slit1 and **Slit2**, known chemorepellents for RGC axons, regulate distinct aspects of intraretinal pathfinding in different regions of the retina.
Y
N
U
Elevated temperature had no significant effect on the **level** of transcription of **these genes**.
Y
N
U
Antibody-**drug** conjugates that target **TROP2** represent a promising approach for the treatment of TROP2-expressing cancers including lung cancer and breast cancer.
Y
N
U
Our data demonstrate that Tacstd2 expression and membrane localization are tightly associated with stratified epithelial homeostasis, while **loss of** **TACSTD2** was identified in poorly differentiated SCC tissues collected from cervix, esophagus, head and neck.
Y
N
U
Soluble **human leukocyte antigen-g** and its insertion/deletion **polymorphism** in papillary thyroid carcinoma: novel potential biomarkers of disease?
Y
N
U
**Histocompatibility leukocyte antigen-G** is not **expressed** by endometriosis or endometrial tissue.
Y
N
U
{"name":"Target Alteration Quiz", "url":"https://www.quiz-maker.com/QPREVIEW","txt":"Test your knowledge on the role of various signaling pathways and genes in biological processes with our comprehensive Target Alteration Quiz. Dive into a collection of 21 thought-provoking questions designed to challenge your understanding and enhance your learning. Assess your comprehension of signal transduction and gene expression. Explore the effects of specific genes and proteins in developmental biology. Great for students, researchers, and anyone interested in cell signaling!","img":"https:/images/course1.png"}
More Quizzes
Test Your Knowledge of Hematology and Neural Crest Biology
6363
RNA Isolation Quiz 2 - Concepts
14710
Gene Fusion Evaluation
630
Genetic Facts Survey
21100
Frazer Lab CARDiPS Election . . . DEADLINE to vote: Monday 10/10/16 @ Noon
630
Real-Time PCR and Genetic Analysis Quiz
18948
Life4QuestionBankQuiz
9950137
Chapter 8 - Osteolysis and Implant Loosening
13628
Inner Hair Cell Regeneration - Newslytica Quiz
840
PHPC
11619
External Brain Structures
6342
Nociception mediation
1168