Protein Synthesis Inhibitors
Master Protein Synthesis Inhibitors Quiz
Test your knowledge on protein synthesis inhibitors and their mechanisms of action with this comprehensive quiz. Covering various classes of antibiotics, including tetracyclines, aminoglycosides, macrolides, and more, this quiz is designed for healthcare students, professionals, and anyone interested in pharmacology.
You'll explore:
- Mechanisms of action
- Resistance mechanisms
- Treatment options and side effects
MOA for tetracyclins?
Reversible binding to 30s subunit
Reversible binding to 50s subusnit
Prevents formation of ribosome complex
MOR for tetracyclins?
PBP mutation
Efflux pumps
Porin size change
A pt comes has SIADH what drug can be used to treat?
Doxycycline
Tigecycline
Demeclocycline
Tetracycline
What tetracycline is used for biliary tree infections?
Minocycline
Tetracycline
Doxycycline
Tigecycline
What diseases are tetracyclins used to treat
Tick borne illnesses, pertussis, MRSA
Tick borne illnesses, MRSA, atypical resp infections
Clamydia, walking pneumonia, tick borne illnesses
Side effects of Tetracyclins include? Select all correct answers
Arthralgia
GI upset
Gray baby syndrome
Photosensitivity
Aplastic anemia
Ototoxicity
Teratogenic
Ionic displacement
Serotonin syndrome
What are the aminoglycosides?
Erythromycin, tobramycin, azithromycin
Erythromycin, clarithromycin, azithromycin
Gentamycin, tobramycin
What drugs are used to synergize with aminoglycosides?
Penicillins, glycopeptides
Tetracyclins
Ketolides
Chloramphenicol
Main MOR for aminoglycosides?
PBP mutation
Beta lactamases
Drug inactivation by bacterial enzymes
Aerobic or basic environment of cell
When should aminoglycosides be used?
Anaerobic g+ infections
Penicillin resistant pathogens
Serious aerobic gram +/- infections (UTI/pneumonia)
MRSA
What aminoglycoside is used for pseudomonas?
Gentamycin
Erythromycin
Azithromycin
Tobramycin
Side fx of aminoglycosides include? (select all)
Ototoxicity
Teratogenic
Nephrotoxic
Hepatitis
Aplastic anemia
How are tetracyclins metabolized?
Unchanged renal excretion
Cyt C
Cyt p450
Cyt p124
What should not be given with Tetracyclins due to limiting absorption?
Peanut butter
Fruits
Milk
Vegetables
What body part can be altered with tetracyclins in an adult?
Retina/lens
Toes/toenails
Teeth/bones
MOA of aminoglycosides
Bind 50s subunit
Bind 30s subunit
Binds PBP
Prevents entire ribosome complex formation
What are the macrolides?
Clindamycin, tobramycin, erythromycin
Erythromycin, azithromycin, clindamycin
Erythromycin, Azithromycin, clarithromycin
Erythromycin, clarithromycin, clindamycin
MOA of Macrolides?
Bind to 50s subunit
Bind to 30s subunit
Prevent entire ribosomal complex formation
MOR of macrolides?
Efflux pumps
Porin size change
Inducible methylases
Inactivation via bacterial enzymes
What does a positive D-test tell you?
The porin size is too small for the drug
The bacteria will efflux the drug
Bacteria has inducible methylases that alter ribosomal binding site
PBP has a mutation that won't allow the drug to bind
What diseases are macrolides recommended for? (select all)
Whooping cough
MRSA
Biliary tree infections
Neonatal chlamydia of the eye prophylaxis
Atypical resp infections
Chlamydia trachomatis
Major side effect of Macrolides? (select all)
Acute hepatits
Myalgia
Prolonged QTc interval
Arthralgia
Thrombocytopenia
Erythromycin inhibits what enzyme?
Cyp2D6
Cyp2C9
Cyp1A2
Cyp3A4
Ketolides MOA?
Bind 50s subunit
Bind 30 subunit
Prevents entire ribosome formation
What is the major side effect of ketolides?
Hepatitis
Arthralgia
Myalgia
What is the only ketolide we need to know?
Clindamycin
Telithromycin
Linezolid
Chloramphenicol
Lincosamides MOA?
Bind to 50s subunit
Bind to 30s subunit
Prevent entire ribosome complex formation
Lincosamides MOR?
Porin size change
Efflux pumps
Inducible methylases
Anaerobic cells
What is the only lincosamide we need to know?
Dalfopristone
Linezolid
Azithromycin
Clindamycin
What are lincosamides used for? (Select all)
Gram + aerobic infections
Gram - aerobic infections
Gram + and - anaerobic infections
Gram + and - aerobic infections
MRSA
VRE
Abscesses
Streptogramins MOA?
Bind to 50s subunit
Bind to 30s subunit
Binds to both 30s and 50s
Binds to 23s and 50s
What are the streptogramins?
Quinupristin/Dalfopristin
Telithromycin/Azithromycin
Chloramphenicol/Linezolid
Doxycycline/Minocycline
What are the streptogramins used for? (select all)
Gram - bacteria
Pseudomonas
Gram + bacteria
Penicillin resistant pathogens
MRSA
A pt comes in complaining of muscle pain and joint pain after being admitted for an infection, what drug was she most likely given?
Clindamycin
A tetracycline
Chloramphenicol
Quinupristin/Dalfopristin
Chloramphenicol MOA?
Binds to 50s subunit
Binds to 23s subunit
Binds to 30s subunit
Major side fx of Chloramphenicol? (Select all)
Irreversible aplastic anemia
Serotonin syndrome
Neuropathy
Gray baby syndrome
Nephrotoxicity
A pt on an SSRI needs some meds for an infection, which antibiotic will you def avoid?
Chloramphenicol
Streptogramins
Linezolid
Macrolides
A pt taking warfarin comes in for an infection, which antibiotic would you like to avoid prescribing?
Linezolid
Streptogramins
Chloramphenicol
Clindamycin
MOA of Oxazolidinones?
Bind to 30s subunit
Bind to 50s subunit
Prevent entire ribosome complex formation
Binds to 23s subunit
What are the oxazolidinones?
Chloramphenicol
Clindamycin
Telithromycin
Linezolid
What drug is given for VRE?
Clindamycin
Chloramphenicol
Linezoliid
Tobramycin
The side fx of oxazolidinones are? (Select all)
Thrombocytopenia
Anemia/Neutropenia
Optic/Peripheral neuropathy
Lactic Acidosis
Serotonin Syndrome
Hepatitis
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