Letrozole
Most common hormonal therapy
Immunotherapy
Tamoxifen-Adjuvant Therapy
Targeted drug therapy
Chemotherapy
Enzyme that convert androgens to estrogens
Lypase
Amylase
Trypsin
None of the above
The following are the side effects of Tamoxifen-Adjuvant Therapy except:
Irregular periods
Venous thrombosis
Nausea
Constipation
Which is not a function of Letrozole?
Prevents use of estrogen by blocking cancer cell receptors for estrogen
Less estrogen in blood and less estrogen to trigger cancer cell growth
Lowers the amount of estrogen
It competitively binds to the haem of the cytochrome P450 subunit of the aromatase enzyme
Letrozole is not used in premenopausal women.
True
False
In Pharmacokinetics, what is the halflife of Letrozole?
18 hours
28 hours
32 hours
42 hours
48 hours
In Pharmacokinetics, what is the percentage of Letrozole's Bioavailability?
99.99%
100%
80%
95%
Letrozole is not contraindicated during pregnancy, lactation and in pre-menopausal women. It is also not contraindicated in severe hepatic dysfunction
True
False
The following are the side effects of Letrozole except:
Headache
Vomiting
Anorexia
Cancer of endometrium
What is the recommended dose of Letrozole?
2.5mg once daily
2.5mg twice daily
2mg once daily
2mg twice daily
Which of the following trials is the first study to prove the benefit of extended adjuvant therapy in postmenopausal women after standard adjuvant tamoxifen
MA17
BIG1-98
In the trial of MA17, Letrozole reduces recurrence of contralateral breast cancer by almost 50%
True
False
A trial in which a comparison of Letrozole and Tamoxifen in Post menopausal women with early breast cancer was conducted
MA17
BIG1-98
Reduces plasma levels of estrone,estradiol and estrone sulfate by >74-95%
True
False
After menopause, ovaries functions and estrogen is derived from ovarian tissues
True
False
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