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MoA for drugs 1123
B lactams and glycopeptides
Affect PM permeability
Punches holes in membrane
Affects membrane fun
ction
Target late stage maturation of peptidoglycan
Bacitracin, D cycloserine and fosfomycin
Target late stages of maturation of peptidoglycan
Interferes with early stages of peptidoglycan
Effect PM
Inhibit protein synthesis
Polymyxins and colistin
Affect permeability of PM
Affect membrane fun
ction
Inhibit peptidoglycan synthesis
Punches hole in membrane
Daptomycin
Affect permeability of PM
Affect membrane fun
ction
Inhibit peptidoglycan synthesis
Punches hole in membrane
Antimicrobial peptides
Affect permeability of PM
Affect membrane fun
ction
Inhibit peptidoglycan synthesis
Punches hole in membrane
Tetracyclins, macrolides, aminoglycosides, chloramphenicol, fusidic acid
Inhibit protein synthesis
Inhibit nucleic acid synthesis
Inhibits intracellular parasites
Inhibit peptidoglycan synthesis
Quinolones, rifampicin, sulphanamides, trimethoprim, mitronidazole
Inhibit protein synthesis
Inhibit nucleic acid synthesis
Inhibits intracellular parasites
Inhibit peptidoglycan synthesis
Tetracyclines, doxycycline, reduced tick exposurem
Rickettsia
Chlamydia
Mycobacteria
Intracellular parasites
Tetracycline, doxycycline, macrolides, azithromycin
Chlamydia
Rickettsia
Mycobacteris
Gastroenteritis
Isoniazid, rifampicin, pyrazinamide, ethambutol
Chlamydia
Rickettsia
Mycobacteria
Gastroenteritis
Amphotericin
Inhibits cyp450
Stops ergosterol synthesis
Binds to sterols, disrupting osmotic integrity
Antibiotic
Itrconazole
Inhibits cyp450, stopping ergosterol synth
Broad spectrum
Binds to sterols
Antibiotic
Zidovudine
NRTI
NNRTI
Protease inhibitor
Fusion inhibitor
Receptor antagonist
Neuraminidase inhibitor
Efavirenz
NRTI
NNRTI
Protease inhibitor
Fusion inhibitor
Receptor antagonist
Neuraminidase inhibitor
Atazanavir
NRTI
NNRTI
Protease inhibitor
Fusion inhibitor
Receptor antagonist
Neuraminidase inhibitor
Enfuviritide
NRTI
NNRTI
Protease inhibitor
Fusion inhibitor
Receptor antagonist
Neuraminidase inhibitor
Maravirac
NRTI
NNRTI
Protease inhibitor
Fusion inhibitor
Receptor antagonist
Neuraminidase inhibitor
Zanamivir
NRTI
NNRTI
Protease inhibitor
Fusion inhibitor
Receptor antagonist
Neuraminidase inhibitor
Aciclovir is
Guanosine analogue
Viral RNA inhibitor
NRTI
Non competitive inhibitor
Chloroquine, mefloquine, doxycycline, malarone
Malaria
Chlamydia
Helminth treatment
Rickettsia
Metronidazole, tinidazole, diloxanide fluorate
Amoebic dysentry
Malaria
Chlamydia
Rickettsia
Helminth treatment
1st line mebendazole
Depends on worm
1st line niclosamide
No treatment available in UK
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