Thalassemia

Which chromosome is responsible for the genes controlling alpha globin synthesis?

Chromosome 11
Chromosome 16
Chromosome 9
Chromosome 21
What is the most common hemoglobin type in adults?
HbA (α2β2)
HbA2 (α2δ2)
HbF (α2γ2)
HbS
In alpha-thalassemia, the severity of the disease depends on the number of which type of globin chain?
Alpha
Beta
Delta
Gamma
If an individual has a three-gene deletion in alpha-thalassemia, they are likely to have:
Silent carrier status
HbH disease
Bart's hydrops fetalis
Alpha-thalassemia trait
Complete deletion of all four alpha globin genes in alpha-thalassemia leads to
HbH disease
Silent carrier status
Bart's hydrops fetalis
Alpha-thalassemia trait
Beta-thalassemia results from mutations in the gene located on which chromosome?
Chromosome 16
Chromosome 11
Chromosome 21
Chromosome 9
Which of the following best describes beta-thalassemia major?
Silent carrier status with no clinical symptoms
Mild anemia with no need for transfusions
Severe anemia requiring regular blood transfusions
Hemoglobin composition similar to that of a normal adult
In beta-thalassemia minor (or trait), the individual typically exhibits
Normal hemoglobin levels and no symptoms
Severe anemia and organomegaly
Mild anemia and microcytosis
High levels of fetal hemoglobin
In patients with thalassemia, which type of mutation typically leads to beta-thalassemia intermedia?
Deletion of all alpha globin genes
Point mutations in both beta globin genes with partial function
Single beta globin gene mutation
Complete absence of beta globin chains
In the context of thalassemia, which hemoglobin variant is characterized by the presence of four gamma chains (γ4)?
HbH
HbA2
HbF
Hb Bart's
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