Genetics in myocarditis and pericarditis

In which patients with myocarditis/pericarditis is genetic testing not recommended according to the ESC 2025 Guidelines?

Family history of inflammatory myopericardial syndrome (IMPS), inherited or suspected cardiomyopathy

Severe ventricular arrhythmias

Significant LGE (ring-like pattern or septal) or persistent LVEF systolic dysfunction

Recurrent myocarditis or persistent troponin elevation

Genetic testing is indicated in all of the above

Which of the following genes is most likely to be involved in complicated myocarditis in paediatric patients?

DSP

Sarcomeric genes

LMNA

FLNC

PKP2

Regarding the possible inheritance of recurrent pericarditis, indicate the correct answer:

Genetic testing is never indicated

It is not necessary to ask about family history

Around 15% of patients may have mutations in genes related to the inflammatory response

More than 90% of patients have a positive result in genetic testing

Recurrent pericarditis has not been associated with genetic variants for monogenic autoinflammatory diseases

What should be next step in a carrier of a LP/P variant in the DSP gene with myocarditis-like episode that is not responding to first line therapy?

Add colchicine

Higher doses of NSAID

Immunosupression

Any of the previous

None of the previous

Which of the following characteristics is not typical in cardiomyopathy patients with DSP mutations?

Left ventricular hypertrophy

Around 15% may have episodes of myocarditis

High incidence of ventricular arrhythmias

Fibrosis that precedes the presence of systolic dysfunction

T wave inversion in precordial leads

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