Biochem

Biochemistry Challenge

Test your knowledge of biochemistry with our extensive quiz featuring 31 questions on various topics including nucleotides, enzymes, and metabolic pathways.

Whether you're a student, educator, or enthusiast, this quiz will provide insights and deepen your understanding of biochemical processes.

In-depth questions across a wide array of biochemistry topics
Perfect for students and professionals alike
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31 Questions8 MinutesCreated by AnalyzingMolecule712

Carbamoyl phosphate synthetase II: CPS II

Is a mitochondrial enzyme

Uses an alpha-amine group of glutamate as a nitrogen source

Its product is carbamoyl aspartate

None of the above

What is true?

Lesch-Nychan syndrome is associated with a virtual comlete deficiency of adenine phosphoribosyltransferase

In ≈ 90% of induviduals with hyperuricemia, the cause is underexcretion of uric acid

The type of severe combined immunodeficiency (SCID) is caused by deficiency of adenosine deaminase

What is true?

Uracil is methylated thymine

PRPP contains a N-glycosidic bond

Aspartate is a source of an atom in the purine ring

None of the above

Ribonucleotide reductase:

Converts ribonucleotides to deoxiribonucleotides

Need for action the oxidized form of thioredoxin

Is activated by ATP

What is true?

Molybdenum serves as a cofactor of xanthine oxidase

Thioredoxin reductase activity depends on NADH+ H+

PRPP is an inhibitor of the carbamoyl phosphate synthetase II

What is true?

In DNA molecules the concentration of adenine equalizes the amount of thymidine

MRNA frequently contains internal

Anticodon arm of tRNA terminates in CpCpAoh

What is true?

At physiological pH, nucleotides have a negative charge

Uric acid is intermediate in metabolism of sugar

Dinucleotide is metabolites composed of two molecules of nucleotides

What is true?

At physiological pH, nucleotides have no charge

Uric acid is the intermediate in metabolism of sugar

ADP means "phosphate of adenine dinucleotide"

None of the above

Ribonucleotide reductase:

Is activated by dATP

Converts CDP to dCDP

Needs oxidized thioredoxin for action

None of the above

What is true?

CO2 is a donor of two carbons in the synthesis of pyrimidine ring

Carbamoyl phosphate synthetase II is located in cytosol

Gout is a disease associated with pyrimidines degradation

CPSII is located in cytosol and is involved in the pyrimidine pathway. Its source of nitrogen is from glutaMINE and regulators are PRPP as an activator and UTP as an inhibitor

What is true?

Glutamine is a donor of two nitrogen atoms for the purine ring

GMP is an inhibitor of IMP dehydrogenase

Xanthine oxidase catalyzes the conversion of guanine to xanthine

Thiroredoxin:

Is a cofactor of one of the enzymes of IMP biosynthesis

Is a coenzyme of xanthine synthesis pathway

Is a coenzyme of thioredoxin reductase

Is a cofactor used in the conversion of ribonucleotides to deoxyribonucleotides

What is true?

Lesch-Nyhan syndrome is caused by a virtually complete deficiency of HGPRT

The cause of hyperuricemia in over 90% of people is underexcretion of uric acid

Adesine deaminase deficiency is the cause of accumulation of adenosine

Ribonucleotide reductase:

Is specific for the reduction of purine ribonucleoside diphosphates only

Requires a protein coenzyme

Is inhibited by dATP

Is activated by ATP

5-phosphoribosyl-1-pyrophosphate; PRPP:

Activates GPAT

Is a source of ribose-5-phosphate group in purine salvage pathways

Activates carbamoyl phosphate synthetase II

What is true?

HGPRT deficiency can be a cause of hyperuricemia

Folic acid analogs increase the rate of DNA replication

ADA deficiency can lead to severe combined immunodeficiency (SCID)

What is true?

Amide nitrogen (R) of glutamine, aspartate and CO2 are sources of the individual atoms of the pyrimidine ring

Uric acid is the final product of human purine nucleotide degradation

N10-formyl-THF is the source of two carbons during the purine nucleotides synthesis

What is hydroxyurea used for?

It is a drug used in treatment of cancers such as a melanoma. It is also used in threatment of sickle cell anemia

Explain the function of substrate specificity sites:

Binding of nucleosides triphosphates to these sites regulates substrate specificity causing an increase in conversion of different species of ribonucleotides to deoxyribonucleotides

What is purine nucleoside phosphorylase (PNP) deficiency?

It is an autosomal recessive deficiency, which only affects T-cells

Ribonucleotide reductase:

Is specific for the reduction of purine ribonucleoside diphosphates only

Requires a protein coenzyme

Is inhibited by dATP

Is activated by ATP

What is true?

HGPRT deficiency can be a cause of hyperuricemia

Folic acid analogs increase the rate of DNA replication

ADA deficiency can lead to severe combined immunodeficiency (SCID)

What is true?

CO2, R-amide of glutamate and aspartate are the sources of the individual atoms of the pyrimidine ring

Uric acid is the final product of purine nucleotide degradation

N10-formyl-THF is the source of two carbon atoms during pyrimidine nucleotide synthesis

Lesch-Nyhan syndrome:

De novo purine synthesis is increased

Purine degradation is increased

IMP and GMP levels are increasesd

IMP and GMP levels are decreased

Ribonucleotide reductase:

Is specific solely for purine ribonucleoside diphosphates

Requires a protein coenzyme

Is inhibited by dATP

What is true?

Pyrimidine nucleosides can be used to treat orotic aciduria

PRPP serves as a homotropic effector in the regulation of GPAT activity

In the treatment of ADA deficiency gene therapy is an option

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